You’re using a public version of DrugPatentWatch with 5 free searches available | Register to unlock more free searches. CREATE FREE ACCOUNT

Last Updated: April 26, 2024

Claims for Patent: 4,442,133

✉ Email this page to a colleague

« Back to Dashboard

Summary for Patent: 4,442,133

Title:	Antibiotic bonding of vascular prostheses and other implants
Abstract:	A method of preparing a surgical vascular graft wherein a length of graft material carries an absorbed coating of tridodecyl methyl ammonium chloride (TDMAC) surfactant and an antibiotic bound thereto. A length of graft material such as polytetrafluoroethylene or Dacron is soaked in a 5% by weight solution of TDMAC for 30 minutes at room temperature, air dried and then washed in distilled water to remove excess TDMAC. The graft carrying the absorbed cationic TDMAC surfactant coating is incubated in a solution of negatively charged antibiotic for one hour, washed in sterile water to remove unbound antibiotic and stored for use in the operating room.
Inventor(s):	Greco; Ralph S. (Basking Ridge, NJ), Harvey; Richard A. (East Brunswick, NJ)
Assignee:
Application Number:	06/351,324
Patent Claims:	1. The method of preparing a vascular graft comprising the steps of preparing a length of a graft material, soaking said length of graft material in a solution of about 5% by weight of tridodecyl methyl ammonium chloride in ethanol for about 30 minutes at room temperature, washing said graft in distilled water to remove excess tridodecyl methyl ammonium chloride but leaving an adsorbed coating thereon, incubating, for about one hour, the graft carrying the adsorbed coating of tridodecyl methyl ammonium chloride in a solution of antibiotic selected from the group consisting of penicillin, oxacillin, ticarcillin, carbenicillin, the cephalosporins, and cefoxitin, washing the graft in sterile water to remove unbound antibiotic, and storing the graft for use in the operating room. 2. The method defined by claim 1 wherein said graft material is polytetrafluoroethylene. 3. The method defined in claim 1 wherein said graft material is polyethylene teraphthalate.

Details for Patent 4,442,133

Glossary

Subscribe to access the full database, or Try a Trial
Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Merck Sharp & Dohme Corp.	ZOSTAVAX	zoster vaccine live	For Injection	125123	05/25/2006	⤷ Try a Trial	2039-09-23
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

Make Better Decisions: Try a trial or see plans & pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.