Claims for Patent: 4,414,988

Summary for Patent: 4,414,988

Title:	Tobacco smoke filter
Abstract:	A tobacco smoke filter capable of effectively removing carcinogenic substances from tobacco smoke is presented. This tobacco filter contains an aqueous solution of a compound having a metallic ion or especially ferric ion binding protoporphyrin ring structure, as a removal agent of carcinogenic substances from the tobacco smoke, and a porous carrier therefor.
Inventor(s):	Yagi; Michiko (Tokyo, JP)
Assignee:	Kabushiki Kaisha Advance Kaihatsu Kenkyujo (Nihonbashi, JP)
Application Number:	06/294,991
Patent Claims:	1. A tobacco smoke filter comprising an aqueous solution of at least one compound having a metallic ion binding protoporphyrin ring structure as a removal agent of carcinogenic substances from tobacco smoke, and a porous carrier or container therefore, said compound in the aqueous solution being present at a concentration ranging from 0.1 to 20 mM, said concentration being sufficient for effectively removing said carcinogenic substances from the tobacco smoke. 2. A tobacco smoke filter of claim 1, in which said compound is defined as a compound having a ferric ion binding protoporphyrin ring structure. 3. A tobacco smoke filter of claim 2, in which said compound is selected from the group consisting of catalase, Methemoglobin, hemin and their derivatives. 4. A tobacco smoke filter of claim 1, in which said compound substantially consists of a ferric ion binding protoporphrin ring. 5. A tobacco smoke filter of claim 4, in which said compound is selected from the group consisting of hemin, hematin and their derivatives. 6. A tobacco smoke filter of claim 1, wherein said carcinogenic substances removed are benzo (.alpha.) pyrene and derivatives thereof and wherein said at least one compound is hemin. 7. A tobacco smoke filter comprising a substantially cylindrical holder body having a hollow chamber constricted to be of small diameter to define a mouthpiece at one end and having an opening at the other end dimensioned to insert therein the end of a cigarette, and a porous filter substrate of substantially columnar shape contained in said chamber for filtering the tobacco smoke passing therethrough, said filter substrate being impregnated with an aqueous solution of hemin and/or its derivatives, said hemin and/or its derivatives being present in a concentration ranging from 0.1 to 20 mM, said concentration being sufficient for effectively removing carcinogenic substances from the tobacco smoke passing through said filter. 8. A tobacco smoke filter of claim 7, in which said aqueous solution of hemin and/or its derivatives has a concentration in the range of 0.5 to 10 mM and an amount in the range of 0.1 to 1.5 ml. 9. A tobacco smoke filter of claim 7 or 8, in which said derivative of hemin is hematin. 10. A tobacco smoke filter of claim 7, wherein said carcinogenic substances removed are benzo (.alpha.) pyrene and derivatives thereof and wherein said filter substrate is impregnated with an aqueous solution of hemin.

Details for Patent 4,414,988

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Recordati Rare Diseases, Inc.	PANHEMATIN	hemin for injection	For Injection	101246	07/20/1983		2000-11-15