You’re using a public version of DrugPatentWatch with 5 free searches available | Register to unlock more free searches. CREATE FREE ACCOUNT

Last Updated: May 8, 2024

Claims for Patent: 4,391,824

✉ Email this page to a colleague

« Back to Dashboard

Summary for Patent: 4,391,824

Title:	Ureylenebis (hydroxy naphthalenesulfonic acids)
Abstract:	Methods of use and compositions of matter of certain ureides of substituted naphthalenesulfonic acids and salts thereof, useful as inhibitors of connective tissue destruction.
Inventor(s):	Siuta; Gerald J. (New City, NY), Bernstein; Seymour (New City, NY)
Assignee:	American Cyanamid Company (Stamford, CT)
Application Number:	06/286,736
Patent Claims:	1. A method of inhibiting connective tissue destruction in a warm-blooded animal suffering from connective tissue destruction disease which comprises administering to said warm-blooded animal an effective connective tissue destruction inhibiting amount of a compound selected from those of the formula: ##STR5## wherein R.sub.1 is selected from the group consisting of hydrogen and --SO.sub.3 A; R.sub.2 is selected from the group consisting of hydrogen, ortho-SO.sub.3 A, ortho-methyl and meta-methyl; and A is selected from the group consisting of hydrogen and a nontoxic pharmaceutically acceptable cation salt. 2. A method of inhibiting the degradation sequelae of collagenase activity in a warm-blooded animal suffering from elevated levels of collagenase which comprises administering to said warm-blooded animals an effective collagenase inhibiting amount of a compound selected from those of the formula: ##STR6## wherein R.sub.1 is selected from the group consisting of hydrogen and --SO.sub.3 A; R.sub.2 is selected from the group consisting of hydrogen, ortho-SO.sub.3 A, ortho-methyl and meta-methyl; and A is selected from the group consisting of hydrogen and a nontoxic pharmaceutically acceptable cation salt. 3. The method according to claim 1 or 2, wherein the compound is 4,4'-[ureylenebis(m-phenylenecarbonylimino)]bis[5-hydroxy-2,7-naphthalened isulfonic acid]tetrasodium salt. 4. The method according to claim 1 or 2, wherein the compound is 3,3'-[ureylenebis(m-phenylenecarbonylimino)]bis[5-hydroxy-2,7-naphthalened isulfonic acid]tetrasodium salt. 5. The method according to claim 1 or 2, wherein the compound is 4,4'-[ureylenebis(3-methyl-p-phenylenecarbonylimino)]bis[5-hydroxy-2,7-nap hthalenedisulfonic acid]tetrasodium salt. 6. The method according to claim 1 or 2, wherein the compound is 4,4'-[ureylenebis(2-methyl-3,1-phenylenecarbonylimino)]bis[5-hydroxy-2,7-n aphthalenedisulfonic acid]tetrasodium salt. 7. The method according to claim 1 or 2, wherein the compound is 4,4'-[ureylenebis(6-methyl-3,1-phenylenecarbonylimino)]bis[5-hydroxy-2,7-n aphthalenedisulfonic acid]tetrasodium salt. 8. The method according to claim 1 or 2, wherein the compound is 5,5.dbd.-[ureylenebis(2-sulfo-4,1-phenylenecarbonylimino)]bis[4-hydroxy-2- naphthalenesulfonic acid]tetrasodium salt. 9. The method according to claim 1 or 2, wherein the compound is administered internally. 10. The method according to claim 1 or 2, wherein the compound is administered topically. 11. The method according to claim 1 or 2, wherein the compound is administered periodontally in the oral cavity. 12. The method according to claim 1 or 2, wherein the compound is administered intra-articularly. 13. The method according to claim 1 or 2, wherein the compound is administered parenterally. 14. The method according to claim 1, wherein said warm-blooded animal is suffering from periodontal disease. 15. The method according to claim 1, wherein said warm-blooded animal is suffering from diseases of the teeth.

Details for Patent 4,391,824

Subscribe to access the full database, or Try a Trial
Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Smith & Nephew, Inc.	SANTYL	collagenase	Ointment	101995	06/04/1965	⤷ Try a Trial	2039-03-29
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

Make Better Decisions: Try a trial or see plans & pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.