Claims for Patent: 4,252,668

Summary for Patent: 4,252,668

Title:	Process for preparation of potassium-38
Abstract:	A solution of potassium-38 suitable for use as a radiopharmaceutical and a method for its production. Argon is irradiated with protons having energies above the threshold for the .sup.40 Ar(p,3n).sup.38 K reaction. The resulting potassium-38 is dissolved in a sterile water and any contaminating chlorine-38 is removed.
Inventor(s):	Lambrecht; Richard M. (Quogue, NY), Wolf; Alfred P. (Setauket, NY)
Assignee:	The United States of America as represented by the United States (Washington, DC)
Application Number:	06/014,179
Patent Claims:	1. A method for producing a solution of potassium-38 comprising: (a) irradiating a target volume of essentially pure argon gas, said gas substantially comprising argon-40, with protons having energies above the threshold for the .sup.40 Ar(p,3n).sup.38 K reaction; (b) rinsing the chamber containing said gas with sterile water, so as to form a solution of potassium-38; (c) treating said solution so as to remove any chlorine-38. 2. The method of claim 1, wherein said protons have energies of about 32.5 MeV. 3. The method of claim 1 wherein said protons have energies substantially above the .sup.40 Ar(p,3n).sup.38 K threshold and said gas is at a pressure sufficient to degrade said proton energies to about said threshold within said volume. 4. The method of claim 3 wherein said protons enter said target gas with energies of about 32.5 MeV and said energies are degraded to about 29.8 MeV within said volume. 5. The method of claim 4 wherein step (c) is carried out by passing said solution through an ion exchange resin. 6. The method of claim 5, wherein said solution is resterilized. 7. The method of claim 1 wherein said solution is resterilized. after step (c). 8. The method of claim 4 wherein said resterilization is carried out by filtration. 9. The method of claim 1 wherein step (c) is carried out by passing said solution through an ion exchange resin. 10. The method of claim 1 wherein said chamber is formed of nickel. 11. A solution of potassium-38 suitable for use as a radiophrmaceutical made by the method of claims 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10. 12. A sterile solution consisting essentially of potassium-38, its decay products and water, said solution having radioactive purity greater than 99.9% and a total activity and specific activity per milliliter such as to be suitable for use as a radiopharmaceutical.

Details for Patent 4,252,668

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Merck Sharp & Dohme Corp.	ZOSTAVAX	zoster vaccine live	For Injection	125123	05/25/2006		2039-09-23