Claims for Patent: 4,152,412

Summary for Patent: 4,152,412

Title:	Marking vaccine
Abstract:	A vaccine, toxoid or like agent is administered to an animal by injecting the agent (usually intracutaneously) on a physiologically acceptable colored particle, preferably activated charcoal, which has a particle size whereby the colored particle remains at the point of injection to provide a visible mark which evidences administration of the vaccine or toxoid, and a repository of immunologically active material to serve as a booster.
Inventor(s):	Brewer; John H. (Abilene, TX)
Assignee:
Application Number:	05/848,408
Patent Claims:	1. In the method of administering vaccines, antigens, toxoids or other immunizing agents to an animal, the improvement comprising: injecting an effective amount of the agent into the skin of the animal in conjunction with a physiologically acceptable colored particle having a particle size whereby the colored particle remains at the point of injection to provide a visible mark which evidences administration of said agent. 2. The method of claim 1 wherein the agent is adsorbed on said colored particle. 3. The method of claim 2 wherein the colored particle is activated charcoal. 4. The method of claim 3 wherein the colored particle has a particle size of at least 0.5 micron. 5. The method of claim 4 wherein the agent is in lysed form. 6. The method of claim 5 wherein the agent is administered as a combination of the whole organism and the agent in lysed form adsorbed on said activated charcoal. 7. The method of claim 4 wherein the agent is Brucella abortus vaccine. 8. The method of claim 4 wherein the agent is rabies vaccine. 9. The method of claim 4 wherein the agent is killed vaccine. 10. In a method of vaccinating an animal against Brucella abortus, the improvement comprising: injecting into the skin an effective amount of Brucella abortus vaccine adsorbed on a physiologically acceptable colored particle having a particle size whereby the colored particle remains at the point of injection to provide a visible mark which evidences administration of said vaccine. 11. The method of claim 10 wherein the vaccine is in lysed form adsorbed on activated charcoal having a particle size of at least 0.5 micron. 12. A composition for vaccinating an animal, comprising: Brucella Abortus vaccine in lysed form, adsorbed on colored adsorbent particles, said vaccine being adsorbed on colored adsorbent particles having a particle size of at least 0.5 micron to provide upon injection a visible mark and a repository of the vaccine for release over a period of time. 13. The composition of claim 12 wherein the adsorbent particles are activated charcoal. 14. The composition of claim 13 wherein the activated charcoal was subjected to vacuum to remove adsorbed gases prior to adsorption of the vaccine.

Details for Patent 4,152,412

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Bavarian Nordic A/s	RABAVERT	rabies vaccine	For Injection	103334	10/20/1997		1996-05-01
Sanofi Pasteur Sa	IMOVAX RABIES	rabies vaccine	For Injection	103931	02/04/2000		1996-05-01