Claims for Patent: 4,115,195

Summary for Patent: 4,115,195

Title:	Rabies vaccine preparation
Abstract:	A rabies vaccine is prepared by adaptation of the rabies virus to chick-embryo fibroplast cell cultures in progressing dilutions of from 10.sup.-1 to 10.sup.-5 for the inoculation of the cell culture passages and for multiplication in dilutions of from 10.sup.-2 to 10.sup.-5 for inoculation of the growth cultures.
Inventor(s):	Barth; Rudolph (Marburg, Lahn, DE), Jaeger; Oskar (Niederwetter, DE)
Assignee:	Behringwerke Aktiengesellschaft (Marburg, Lahn, DE)
Application Number:	05/786,766
Patent Claims:	1. In a process for preparing a rabies vaccine, the improvement wherein the rabies virus is first adapted to chick-embryo fibroblast cell cultures using a suspension containing the rabies virus in progressing dilutions from 10.sup.-1 to 10.sup.-5 for the inoculation of the cell culture passages and then inoculating growth cultures with a suspension containing the adapted rabies virus in a dilution from 10.sup.-2 to 10.sup.-5 for multiplication of the virus. 2. A process as claimed in claim 1, wherein during the passages the temperature is maintained in the range of from 30.degree. to 38.degree. C. 3. A process as claimed in claim 1, wherein during the passages the temperature is maintained in the range of from 32.degree. to 37.degree. C. 4. A process as claimed in claim 1, wherein chick-embryo fibroblast cells of SPF eggs are used for the vaccine production.

Details for Patent 4,115,195

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Bavarian Nordic A/s	RABAVERT	rabies vaccine	For Injection	103334	10/20/1997		1996-04-14
Sanofi Pasteur Sa	IMOVAX RABIES	rabies vaccine	For Injection	103931	02/04/2000		1996-04-14