Claims for Patent: 3,943,131

Summary for Patent: 3,943,131

Title:	Trifluoromethylmercaptoacetamidocephalosporins
Abstract:	This invention is directed to antibacterial compounds, in particular, to 7-trifluoromethylmercaptoacetamidocephalosporins.
Inventor(s):	De Marinis; Robert M. (King of Prussia, PA), Hoover; John R. E. (Glenside, PA)
Assignee:	SmithKline Corporation (Philadelphia, PA)
Application Number:	05/463,085
Patent Claims:	1. A pharmaceutical composition comprising an antibacterially effective amount of the compound of the formula ##SPC2## in which: A is S-Het; Het is a 5 or 6 membered heterocyclic ring containing 1-4 hetero atoms selected from the group consisting of N, O and S and being unsubstituted or substituted with one or two groups selected from the group consisting of alkyl, alkoxy, alkylthio, each alkyl residue being one to four carbon atoms; C.sub.3 -C.sub.4 cycloalkyl, halogen, hydroxy, mercapto, trifluoromethyl and NR.sub.2 ; and R is hydrogen or C.sub.1 14 C.sub. 6 alkyl, or a pharmaceutically acceptable salt thereof and sterile water or sterile saline as carrier therefor. 2. A pharmaceutical composition as claimed in claim 1 comprising an antibacterially effective amount of a compound where Het is tetrazolyl, thiadiazolyl, triazolyl, or oxadiazolyl, unsubstituted or substituted with one or two C.sub.1 -C.sub.4 alkyl groups, a hydroxy or a mercapto group and sterile water or sterile saline as carrier therefor. 3. A pharmaceutical composition as claimed in claim 2 comprising an antibacterially effective amount of the compound 7-trifluoromethylmercaptoacetamido-3-(5-methyl-1,3,4-thiadiazol-2-ylthiome thyl)-3-cephem-4-carboxylic acid and sterile water or sterile saline as carrier therefor. 4. A pharmaceutical composition as claimed in claim 2 comprising an antibacterially effective amount of the compound 7-trifluoromethylmercaptoacetamido-3-(1-methyltetrazol-5-ylthiomethyl)-3-c ephem-4-carboxylic acid and sterile water or sterile saline as carrier therefor. 5. A pharmaceutical composition as claimed in claim 2 comprising an antibacterially effective amount of the compound 7-trifluoromethylmercaptoacetamido-3-(1,2,3-triazol-4-ylthiomethyl)-3-ceph em-4-carboxylic acid and sterile water or sterile saline as carrier therefor. 6. A pharmaceutical composition as claimed in claim 2 comprising an antibacterially effective amount of the compound 7-trifluoromethylmercaptoacetamido-3-(5-methyl-1,2,4-triazol-3-ylthiomethy l)-3-cephem-4-carboxylic acid and sterile water or sterile saline as carrier therefor. 7. A pharmaceutical composition as claimed in claim 2 comprising an antibacterially effective amount of the compound 7-trifluoromethylmercaptoacetamido-3-(5-hydroxy-1,2,4-triazol-3-ylthiometh yl)-3-cephem-4-carboxylic acid and sterile water or sterile saline as carrier therefor.

Details for Patent 3,943,131

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Merck Sharp & Dohme Corp.	ZOSTAVAX	zoster vaccine live	For Injection	125123	05/25/2006		2039-09-23