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Last Updated: December 31, 2025

Claims for Patent: 11,213,595

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Summary for Patent: 11,213,595

Title:	Antigen responsive antibody-fluorescent dye conjugate and method for fluorescence detection and imaging of target cell using the same
Abstract:	The present invention relates to an antibody-fluorescent dye conjugate capable of cancer cell-specific fluorescence imaging diagnosis. The fluorescent dye comprises a covalently labeled antibody and is quenched by interaction with an amino acid residue such as tryptophan, tyrosine, histidine, and methionine in the antibody and upon binding of the antibody to an antigen present on a cell surface to emit fluorescence, whereby cells having a target antigen thereon can be imaged for diagnosis. When using the antibody-fluorescent dye conjugate according to the present invention during in vitro cell assays, high-throughput screening of cells, and cytodiagnosis based on microfluidics, the presence of cancer cells having a specific antigen expressed thereon can be detected at high specificity and sensitivity without a washing process, and the position of primary and metastatic cancer cells can be detected at high contrast within a short time.
Inventor(s):	Choi Yong-Doo, Kim Hyun-Jin
Assignee:	National Cancer Center
Application Number:	US16138371
Patent Claims:

Details for Patent 11,213,595

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Genzyme Corporation	CAMPATH	alemtuzumab	Injection	103948	May 07, 2001	11,213,595	2038-09-21
Genzyme Corporation	LEMTRADA	alemtuzumab	Injection	103948	November 14, 2014	11,213,595	2038-09-21
Genzyme Corporation	CAMPATH	alemtuzumab	Injection	103948	October 12, 2004	11,213,595	2038-09-21
Merz Pharmaceuticals Gmbh C/o Merz Pharmaceuticals Llc	XEOMIN	incobotulinumtoxina	For Injection	125360	July 30, 2010	11,213,595	2038-09-21
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 11,213,595

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Country	Patent Number	Estimated Expiration
World Intellectual Property Organization (WIPO)	2017171283	⤷ Get Started Free
United States of America	2019091349	⤷ Get Started Free
South Korea	20170111601	⤷ Get Started Free
South Korea	101847264	⤷ Get Started Free
>Country	>Patent Number	>Estimated Expiration

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