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Last Updated: March 27, 2026

Claims for Patent: 11,168,134

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Summary for Patent: 11,168,134

Title:	Methods of treating androgen deprivation therapy resistant prostate cancer
Abstract:	The present invention provides a method of treatment of prostate cancer, comprising administering a therapeutically effective amount of an inhibitor of IL-23 and/or an inhibitor of IL-23R to a mammalian patient in need thereof. The prostate cancer may be castration resistant prostate cancer (CRPC). The inhibitor may, for example, be an anti-IL-23 antibody, such as risankizumab, guselkumab or tildrakizumab. The method of treatment may further comprise administration of androgen deprivation therapy, such as enzalutamide. Also provided is a method of predicting the development of resistance to androgen deprivation therapy (ADT) in a prostate cancer in a mammalian patient and a related screening method.
Inventor(s):	Alimonti Andrea, Calcinotto Arianna, de Bono Johann
Assignee:
Application Number:	US16574828
Patent Claims:

Details for Patent 11,168,134

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Janssen Biotech, Inc.	TREMFYA	guselkumab	Injection	761061	July 13, 2017	11,168,134	2039-09-18
Janssen Biotech, Inc.	TREMFYA	guselkumab	Injection	761061	January 29, 2019	11,168,134	2039-09-18
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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