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Last Updated: March 19, 2026

Claims for Patent: 11,129,910

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Summary for Patent: 11,129,910

Title:	Specific conjugation linkers, specific immunoconjugates thereof, methods of making and uses such conjugates thereof
Abstract:	The present invention relates to novel linkers containing a 2,3-disubstituted succinic group, or 2-monosubstituted, or 2,3-disubstituted fumaric or maleic (trans (E)- or cis (Z)-butenedioic), or acetylenedicarboxyl group for conjugation of a cytotoxic agent, and/or one or more different functional molecules per linker to a cell-binding molecule, through bridge linking pairs of thiols on the cell-binding molecule specifically. The invention also relates to methods of making such linkers, and of using such linkers in making homogeneous conjugates, as well as of application of the conjugates in treatment of cancers, infections and autoimmune disorders.
Inventor(s):	Zhao Robert Yongxin, Yang Qingliang, Huang Yuanyuan, Gai Shun, Zhao Linyao, Ye Hangbo, Guo Huihui, Tong Qianqian, Cao Minjun, Jia Junxiang, Yang Chengyu, Li Wenjun, Zhou Xiaomai, Xie Hongsheng, Lin Chen, Guo Zhixiang, Ye Zhicang
Assignee:	HANGZHOU DAC BIOTECH CO., LTD.
Application Number:	US16074981
Patent Claims:

Details for Patent 11,129,910

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Ferring Pharmaceuticals Inc.	NOVAREL	chorionic gonadotropin	For Injection	017016	January 15, 1974	⤷ Get Started Free	2036-02-04
Ferring Pharmaceuticals Inc.	NOVAREL	chorionic gonadotropin	For Injection	017016	December 27, 1984	⤷ Get Started Free	2036-02-04
Ferring Pharmaceuticals Inc.	NOVAREL	chorionic gonadotropin	For Injection	017016	February 15, 1985	⤷ Get Started Free	2036-02-04
Ferring Pharmaceuticals Inc.	NOVAREL	chorionic gonadotropin	For Injection	017016	February 16, 1990	⤷ Get Started Free	2036-02-04
Bel-mar Laboratories, Inc.	CHORIONIC GONADOTROPIN	chorionic gonadotropin	Injection	017054	March 26, 1974	⤷ Get Started Free	2036-02-04
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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