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Last Updated: April 1, 2026

Claims for Patent: 11,052,052

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Summary for Patent: 11,052,052

Title:	Cholestosome vesicles for incorporation of molecules into chylomicrons
Abstract:	The present invention is directed to a cargo-loaded cholesteryl ester nanoparticle with a hollow compartment (“cholestosome”) consisting essentially of at least one non-ionic cholesteryl ester and one or more encapsulated active molecules which cannot appreciably pass through an enterocyte membrane in the absence of said molecule being loaded into said cholestosome, the cholestosome having a neutral surface and having the ability to pass into enterocytes in the manner of orally absorbed nutrient lipids using cell pathways to reach the golgi apparatus. Pursuant to the present invention, the novel cargo loaded cholestosomes according to the present invention are capable of depositing active molecules within cells of a patient or subject and effecting therapy or diagnosis of the patient or subject.
Inventor(s):	Schentag Jerome J., McCourt Mary P., Mielnicki Lawrence, Hughes Julie
Assignee:	THERASYN SENSORS, INC.
Application Number:	US16527579
Patent Claims:

Details for Patent 11,052,052

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Eli Lilly And Company	HUMALOG	insulin lispro	Injection	020563	June 14, 1996	11,052,052	2039-07-31
Eli Lilly And Company	HUMALOG	insulin lispro	Injection	020563	August 06, 1998	11,052,052	2039-07-31
Eli Lilly And Company	HUMALOG	insulin lispro	Injection	020563	September 06, 2007	11,052,052	2039-07-31
Eli Lilly And Company	HUMALOG	insulin lispro	Injection	020563	June 06, 2017	11,052,052	2039-07-31
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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