Claims for Patent: 10,940,181
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Summary for Patent: 10,940,181
| Title: | Combined preparations for the treatment of cancer or infection |
| Abstract: | Combined preparations, and pharmaceutical compositions, comprising: (a) LAG-3 protein, or a derivative thereof that is able to bind to MHC class II molecules; and (b) a programmed cell death protein-1 (PD-1) pathway inhibitor, are described. The PD-1 pathway inhibitor, such as an anti-PD-1 antibody or an anti-PD-L1 antibody, and a soluble derivative of LAG-3, acting as an APC activator, together synergistically activate T cells (in particular, CD8+ T cells). Use of the combined preparations and compositions as medicaments, in particular for the treatment of cancer or infection, and to methods for the treatment of cancer or infection, is described. |
| Inventor(s): | Frederic Triebel, Chrystelle Brignone |
| Assignee: | Immutep SAS |
| Application Number: | US16/733,829 |
| Patent Claims: |
Details for Patent 10,940,181
| Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
|---|---|---|---|---|---|---|---|
| Merck Sharp & Dohme Llc | KEYTRUDA | pembrolizumab | For Injection | 125514 | September 04, 2014 | ⤷ Start Trial | 2040-01-03 |
| Merck Sharp & Dohme Llc | KEYTRUDA | pembrolizumab | Injection | 125514 | January 15, 2015 | ⤷ Start Trial | 2040-01-03 |
| Bristol-myers Squibb Company | OPDIVO | nivolumab | Injection | 125554 | December 22, 2014 | ⤷ Start Trial | 2040-01-03 |
| Bristol-myers Squibb Company | OPDIVO | nivolumab | Injection | 125554 | October 04, 2017 | ⤷ Start Trial | 2040-01-03 |
| Bristol-myers Squibb Company | OPDIVO | nivolumab | Injection | 125554 | August 27, 2021 | ⤷ Start Trial | 2040-01-03 |
| >Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
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