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Last Updated: April 17, 2026

Claims for Patent: 10,940,181


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Summary for Patent: 10,940,181
Title:Combined preparations for the treatment of cancer or infection
Abstract:Combined preparations, and pharmaceutical compositions, comprising: (a) LAG-3 protein, or a derivative thereof that is able to bind to MHC class II molecules; and (b) a programmed cell death protein-1 (PD-1) pathway inhibitor, are described. The PD-1 pathway inhibitor, such as an anti-PD-1 antibody or an anti-PD-L1 antibody, and a soluble derivative of LAG-3, acting as an APC activator, together synergistically activate T cells (in particular, CD8+ T cells). Use of the combined preparations and compositions as medicaments, in particular for the treatment of cancer or infection, and to methods for the treatment of cancer or infection, is described.
Inventor(s):Frederic Triebel, Chrystelle Brignone
Assignee:Immutep SAS
Application Number:US16/733,829
Patent Claims:

Details for Patent 10,940,181

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Merck Sharp & Dohme Llc KEYTRUDA pembrolizumab For Injection 125514 September 04, 2014 ⤷  Start Trial 2040-01-03
Merck Sharp & Dohme Llc KEYTRUDA pembrolizumab Injection 125514 January 15, 2015 ⤷  Start Trial 2040-01-03
Bristol-myers Squibb Company OPDIVO nivolumab Injection 125554 December 22, 2014 ⤷  Start Trial 2040-01-03
Bristol-myers Squibb Company OPDIVO nivolumab Injection 125554 October 04, 2017 ⤷  Start Trial 2040-01-03
Bristol-myers Squibb Company OPDIVO nivolumab Injection 125554 August 27, 2021 ⤷  Start Trial 2040-01-03
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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