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Last Updated: December 19, 2025

Claims for Patent: 10,927,346

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Summary for Patent: 10,927,346

Title:	Enhanced immune effector cells and use thereof
Abstract:	Provided are methods and compositions for obtaining functionally enhanced derivative effector cells obtained from directed differentiation of genomically engineered iPSCs. The derivative cells provided herein have stable and functional genome editing that delivers improved or enhanced therapeutic effects. Also provided are therapeutic compositions and the used thereof comprising the functionally enhanced derivative effector cells alone, or with antibodies or checkpoint inhibitors in combination therapies.
Inventor(s):	Valamehr Bahram, Bjordahl Ryan, Goodridge Jode, Lee Tom Tong
Assignee:	FATE THERAPEUTICS, INC.
Application Number:	US16576411
Patent Claims:

Details for Patent 10,927,346

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Bristol-myers Squibb Company	YERVOY	ipilimumab	Injection	125377	March 25, 2011	10,927,346	2039-09-19
Merck Sharp & Dohme Llc	KEYTRUDA	pembrolizumab	For Injection	125514	September 04, 2014	10,927,346	2039-09-19
Merck Sharp & Dohme Llc	KEYTRUDA	pembrolizumab	Injection	125514	January 15, 2015	10,927,346	2039-09-19
Bristol-myers Squibb Company	OPDIVO	nivolumab	Injection	125554	December 22, 2014	10,927,346	2039-09-19
Bristol-myers Squibb Company	OPDIVO	nivolumab	Injection	125554	October 04, 2017	10,927,346	2039-09-19
Bristol-myers Squibb Company	OPDIVO	nivolumab	Injection	125554	August 27, 2021	10,927,346	2039-09-19
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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