Claims for Patent: 10,787,696

Summary for Patent: 10,787,696

Title:	System for the assessment of protease activity
Abstract:	A system for the identification of proteases and protease inhibitors is provided. The system has at least two components. The first component is a reporter construct with at least one binding site, a transcriptional promoter, an inducible promoter region, and at least one reporter gene, all functionally connected for expression of the reporter gene(s) in functional coordination with a transcriptional activation agent. The second component is a transcriptional activation agent comprising a nucleic acid binding domain, at least one protease substrate domain, and at least one transcriptional activation domain for an inducible promoter. The system allows detection and evaluation of agents affecting protease activity directed to the protease substrate domain. The system also allows for the detection of the presence of proteases in environmental samples.
Inventor(s):	George A. Oyler, Yung-Nien Chang, Yien Che Tsai
Assignee:	Ipsen Pharma SAS
Application Number:	US14/026,014

Details for Patent 10,787,696

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Ipsen Biopharm Limited	DYSPORT	abobotulinumtoxina	For Injection	125274	April 29, 2009		2033-09-13

International Patent Family for US Patent 10,787,696

Country	Patent Number	Estimated Expiration
World Intellectual Property Organization (WIPO)	2011071956
United States of America	2014017697
United States of America	2011143362
South Korea	20120115976
Japan	2013512692
European Patent Office	2510107
Canada	2783242