Claims for Patent: 10,683,319

Summary for Patent: 10,683,319

Title:	Phosphoramidates for the treatment of hepatitis B virus
Abstract:	Disclosed are compounds to the treatment of infectious diseases and methods of treating such diseases. The compounds are derivatives of clevudine.
Inventor(s):	de la Rosa; Abel (Alpharetta, GA), Bluemling; Gregory R. (Decatur, GA)
Assignee:	Emory University (Atlanta, GA)
Application Number:	15/536,237
Patent Claims:	1. A compound having a structure of the following formula: ##STR00116## 2. A pharmaceutical composition for the treatment or prevention of a viral infection comprising a compound or its pharmaceutically acceptable salt, of claim 1, or its pharmaceutically acceptable salt, and a pharmaceutically acceptable carrier. 3. The pharmaceutical composition of claim 2, wherein the viral infection is caused by an infectious agent comprising a DNA virus. 4. The pharmaceutical composition of claim 2 wherein the DNA virus comprises hepadnaviruses. 5. A liposomal composition comprising a liposome and a compound of claim 1, or its pharmaceutically acceptable salt, and a pharmaceutically acceptable carrier. 6. A method of treating or preventing infections caused by DNA viruses comprising administering to a host in need an effective amount of a compound of claim 1, or a pharmaceutically acceptable salt thereof. 7. The method of claim 6, wherein the DNA virus comprises hepadnaviruses. 8. The method of claim 6, wherein at least one second antiviral agent selected from abacavir, acyclovir, acyclovir, adefovir, amantadine, amprenavir, ampligen, arbidol, atazanavir, atripla, boceprevir, cidofovir, combivir, darunavir, delavirdine, didanosine, docosanol, edoxudine, efavirenz, emtricitabine, enfuvirtide, entecavir, famciclovir, fomivirsen, fosamprenavir, foscarnet, fosfonet, ganciclovir, ibacitabine, imunovir, idoxuridine, imiquimod, indinavir, inosine, interferon type III, interferon type II, interferon type I, lamivudine, lopinavir, loviride, maraviroc, moroxydine, methisazone, nelfinavir, nevirapine, nexavir, oseltamivir, peginterferon alfa-2a, penciclovir, peramivir, pleconaril, podophyllotoxin, raltegravir, ribavirin, rimantadine, ritonavir, pyramidine, saquinavir, sofosbovir, stavudine, telaprevir, telbivudine, tenofovir, tenofovir disoproxil, tipranavir, trifluridine, trizivir, tromantadine, truvada, valaciclovir, valganciclovir, vicriviroc, vidarabine, viramidine zalcitabine, zanamivir, zidovudine, and combinations thereof is administered with the compound.

Details for Patent 10,683,319

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Zr Pharma& Gmbh	PEGASYS	peginterferon alfa-2a	Injection	103964	10/16/2002		2040-07-04
Zr Pharma& Gmbh	PEGASYS	peginterferon alfa-2a	Injection	103964	01/07/2004		2040-07-04
Zr Pharma& Gmbh	PEGASYS	peginterferon alfa-2a	Injection	103964	09/29/2011		2040-07-04