Claims for Patent: 10,533,024

Summary for Patent: 10,533,024

Title:	Methods for synthesizing metal mesoporphyrins
Abstract:	Embodiments describe methods of synthesizing metal mesoporphyrin compounds. In embodiments, a metal mesoporphyrin compound may be formed by hemin transmetallation and subsequent hydrogenation of the tin protoporphyrin IX to form a metal mesoporphyrin. In other embodiments, a method of synthesizing a metal mesoporphyrin compound comprises forming a protoporphyrin methyl ester from hemin and converting the protoporphyrin methyl ester intermediate to a metal mesoporphyrin compound through metal insertion and hydrogenation. In other embodiments, a metal mesoporphyrin compound may be formed from hemin by a hydrogen-free hydrogenation method to form a mesoporphyrin IX intermediate followed by metal insertion and hydrogenation. In embodiments, a method of synthesizing a metal mesoporphyrin compound comprises forming a mesoporphyrin IX dihydrochloride intermediate compound and converting the mesoporphyrin IX intermediate to a metal mesoporphyrin compound through metal insertion. In embodiments, a metal mesoporphyrin compound may be formed directly from hemin without isolation of any intermediates.
Inventor(s):	Boucher; Christopher P. (Newmarket, CA), Roe; David (Rockwood, CA)
Assignee:	MALLINCKRODT HOSPTIAL PRODUCTS IP LIMITED (Dublin, IE)
Application Number:	16/125,190
Patent Claims:	1. A method of synthesizing a metal mesoporphyrin compound comprising: hydrogenating hemin with ferrous sulfate, palladium on carbon, and poly(methylhydrosiloxane) in formic acid to form a mesoporphyrin formate; converting the mesoporphyrin formate to a mesoporphyrin IX dihydrochloride intermediate compound; isolating the mesoporphyrin IX dihydrochloride intermediate compound; and inserting a metal into the mesoporphyrin IX dihydrochloride intermediate. 2. The method of claim 1, wherein the metal may be selected from tin, iron, zinc, chromium, manganese, copper, nickel, magnesium, cobalt, platinum, gold, silver, arsenic, antimony, cadmium, gallium, germanium, and palladium. 3. The method of claim 2, wherein the metal is tin. 4. The method of claim 3, wherein the tin is inserted using tin oxide, tin chloride, tin sulfate, tin bromide, tin oxalate, tin pyrophosphate hydrate, tin 2-ethylhexanoate, tin methanesulfonic acid, or tin trifluromethanesulfonate. 5. The method of claim 1, wherein the metal mesoporphyrin compound is stannsoporfin.

Details for Patent 10,533,024

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Recordati Rare Diseases, Inc.	PANHEMATIN	hemin for injection	For Injection	101246	07/20/1983		2031-03-30