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Last Updated: December 17, 2025

Claims for Patent: 10,513,723

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Summary for Patent: 10,513,723

Title:	Decreasing ornithine production to decrease high mannose glycoform content of recombinant proteins
Abstract:	The present invention relates to a method for manipulating the high mannose glycoform content of recombinant glycoproteins by regulating ornithine metabolism during cell culture.
Inventor(s):	Sohye Kang, Chung HUANG, Jr., Hedieh BARKHORDARIAN, Pavel Bondarenko, Zhongqi ZHANG
Assignee:	Amgen Inc
Application Number:	US15/111,470

Details for Patent 10,513,723

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Amgen Inc.	PROLIA	denosumab	Injection	125320	June 01, 2010	⤷ Get Started Free	2034-12-09
Amgen Inc.	XGEVA	denosumab	Injection	125320	November 18, 2010	⤷ Get Started Free	2034-12-09
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 10,513,723

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Country	Patent Number	Estimated Expiration
World Intellectual Property Organization (WIPO)	2015105609	⤷ Get Started Free
United States of America	2020071738	⤷ Get Started Free
United States of America	2016333385	⤷ Get Started Free
United States of America	11254963	⤷ Get Started Free
Singapore	11201605640U	⤷ Get Started Free
Singapore	10201806643W	⤷ Get Started Free
>Country	>Patent Number	>Estimated Expiration

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