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Last Updated: April 26, 2024

Claims for Patent: 10,478,394

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Summary for Patent: 10,478,394

Title:	Compositions and methods to promote wound healing
Abstract:	The present disclosure describes compositions and methods to promote wound healing. The compositions and methods include an interleukin-1 beta (IL-1B) receptor antagonist (IL-1Ra), such as anakinra.
Inventor(s):	Yu; Fu-Shin X. (Troy, MI)
Assignee:	Wayne State University (Detroit, MI)
Application Number:	15/557,407
Patent Claims:	1. A method of promoting healing of a chronic wound in a diabetic subject comprising administering to the chronic wound a therapeutically effective amount of a gel comprising a therapeutic agent consisting of a therapeutic protein consisting of the sequence provided in SEQ ID NO: 26 (anakinra), thereby promoting healing of the chronic wound. 2. The method of claim 1, wherein the chronic wound is a diabetic ulcer. 3. The method of claim 1, wherein the administering is topically administering. 4. The method of claim 1, further comprising applying a wound dressing to the wound. 5. The method of claim 4, wherein the administering and applying are achieved in one step. 6. The method of claim 4, wherein the wound dressing is an adhesive bandage. 7. The method of claim 1 further comprising administering a platelet-derived growth factor and/or Becaplermin.

Details for Patent 10,478,394

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Smith & Nephew, Inc.	REGRANEX	becaplermin	Gel	103691	12/16/1997	⤷ Try a Trial	2035-03-11
Swedish Orphan Biovitrum Ab (publ)	KINERET	anakinra	Injection	103950	11/14/2001	⤷ Try a Trial	2035-03-11
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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