Claims for Patent: 10,434,295

Summary for Patent: 10,434,295

Title:	Treatment catheter including therapeutic energy delivery
Abstract:	The invention includes catheters that have therapeutic agent- and therapeutic energy-delivery capability. In particular embodiments, the catheters include only a single therapeutic energy transducer that is configured to deliver energy to over half of the circumference of the catheter. The therapeutic catheters of the invention allow for faster and more effective thrombus removal because of the simultaneous delivery of therapeutic agents and energy.
Inventor(s):	Stigall; Jeremy (Carlsbad, CA), Johnson; Eric (Woodside, CA)
Assignee:	KONINKLIJKE PHILIPS N.V. (Eindhoven, NL)
Application Number:	15/036,914
Patent Claims:	1. A catheter for administering therapy to vasculature, comprising: a flexible elongated body having a plurality of openings at a distal end of the flexible elongated body; a lumen in fluid communication with at least one of the openings and with a port at a proximal end of the flexible elongated body, wherein the at least one of the openings has a size and shape; and a singular therapeutic energy transducer disposed at the distal end of the flexible elongated body, the singular therapeutic energy transducer comprising at least one open portion configured to deliver therapeutic energy to a target within the vasculature while a therapeutic agent is delivered to the target via the openings, wherein the at least one of the openings is aligned with the open portion of the singular therapeutic energy transducer, wherein the open portion has a size and shape, wherein the size or shape of the open portion is different than the size or shape of the at least one of the openings. 2. The catheter of claim 1, wherein the distal portion of the flexible elongated body has a circumference, and the singular therapeutic energy transducer is configured to deliver energy over greater than half of the circumference. 3. The catheter of claim 1, wherein the singular therapeutic energy transducer is at least about 5 cm in length. 4. The catheter of claim 3, wherein the singular therapeutic energy transducer is aligned parallel to the longitudinal axis of the flexible elongated body. 5. The catheter of claim 3, wherein the singular therapeutic energy transducer is disposed in a helical shape, the helix having an axis that is collinear with the longitudinal axis of the flexible elongated body. 6. The catheter of claim 1, wherein the singular therapeutic energy transducer is configured to deliver ultrasonic energy to the target. 7. The catheter of claim 1, wherein the singular therapeutic energy transducer is configured to deliver thermal energy to the target. 8. The catheter of claim 1, wherein the flexible elongated body comprises a biocompatible polymer. 9. A system for administering therapy to vasculature, comprising: a catheter comprising a flexible elongated body having a plurality of openings at a distal end of the flexible elongated body, a lumen in fluid communication with at least one of the openings and with a port at a proximal end of the flexible elongated body, wherein the at least one of the openings has a size and shape, and a singular therapeutic energy transducer disposed at the distal end of the flexible elongated body, the singular therapeutic energy transducer comprising at least one open portion configured to deliver therapeutic energy to a target within the vasculature while a therapeutic agent is delivered to the target via the openings, wherein the at least one of the openings is aligned with the open portion of the singular therapeutic energy transducer, wherein the open portion has a size and shape, wherein the size or shape of the open portion is different than the size or shape of the at least one of the openings; a therapeutic energy controller operatively coupled to the singular therapeutic energy transducer and configured to control the energy delivered to the target; and a fluid delivery subsystem operatively coupled to the port and configured to control the delivery of therapeutic agents to the target. 10. The system of claim 9, wherein the singular therapeutic energy transducer is at least 5 cm in length. 11. The system of claim 10, wherein the singular therapeutic energy transducer is aligned parallel to the longitudinal axis of the flexible elongated body. 12. The system of claim 10, wherein the singular therapeutic energy transducer is disposed in a helical shape, the helix having an axis that is collinear with the axis of the flexible elongated body. 13. The system of claim 9, wherein the singular therapeutic energy transducer is configured to deliver ultrasonic energy to the target. 14. The system of claim 9, wherein the distal portion of the flexible elongated body has a circumference, and the singular therapeutic energy transducer is configured to deliver energy over greater than half of the circumference. 15. The system of claim 9, wherein the fluid delivery subsystem additionally comprises a syringe or a pump. 16. The system of claim 9, wherein the therapeutic agent is selected from streptokinase, urokinase, alteplase, reteplase, and tenecteplase. 17. A method of delivering a therapeutic agent and therapeutic energy to a biological material inside a vessel, the method comprising: providing a catheter comprising a flexible elongated body having a plurality of openings at a distal end of the flexible elongated body, a lumen in fluid communication with at least one of the openings and with a port at a proximal end of the flexible elongated body, wherein the at least one of the openings has a size and shape, and a singular therapeutic energy transducer disposed at the distal end of the flexible elongated body, wherein the at least one of the openings is aligned with the open portion of the singular therapeutic energy transducer, wherein the open portion has a size and shape, wherein the size or shape of the open portion is different than the size or shape of the at least one of the openings; inserting the catheter into a lumen of a vessel; delivering a thrombolytic agent to the biological material; and and delivering therapeutic energy to the biological material. 18. The method of claim 17, further comprising imaging the biological material after delivery of the thrombolytic agent and therapeutic energy. 19. The method of claim 17, wherein the distal portion of the flexible elongated body has a circumference, and the singular_therapeutic energy transducer is configured to deliver energy over greater than half of the circumference. 20. The method of claim 17, wherein the singular therapeutic energy transducer is at least about 5 cm in length. 21. The method of claim 20, wherein the singular therapeutic energy transducer is aligned parallel to the longitudinal axis of the flexible elongated body. 22. The method of claim 20, wherein the singular therapeutic energy transducer is disposed in a helical shape, the helix having an axis that is collinear with the longitudinal axis of the flexible elongated body. 23. The method of claim 17, wherein the biological material is thrombus. 24. The method of claim 17, wherein the thrombolytic agent is selected from streptokinase, urokinase, alteplase, reteplase, and tenecteplase.

Details for Patent 10,434,295

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Microbix Biosystems Inc.	KINLYTIC	urokinase	For Injection	021846	01/16/1978		2033-11-18
Genentech, Inc.	ACTIVASE	alteplase	For Injection	103172	11/13/1987		2033-11-18
Genentech, Inc.	CATHFLO ACTIVASE	alteplase	For Injection	103172	09/04/2001		2033-11-18