Claims for Patent: 10,398,681

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Summary for Patent: 10,398,681

Title:	Compounds and compositions that bind and stabilize transthyretin and their use for inhibiting transthyretin amyloidosis and protein-protein interactions
Abstract:	Disclosed herein are compounds and compositions thereof which find use in increasing stability of proteins particularly proteins that tend to misfold and form aggregates. Also provided herein are methods for using these compounds and compositions for increasing stability of proteins and thereby decreasing aggregate formation by these proteins. Also disclosed herein are heterobifunctional compounds that include a TTR binding compound connected to a targeting moiety via a linker, for use in disrupting PPIs of a target protein.
Inventor(s):	Isabella A. Graef, Mamoun M. Alhamadsheh
Assignee:	Leland Stanford Junior University
Application Number:	US15/883,750

Details for Patent 10,398,681

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Zenpep, Llc	ZENPEP	pancrelipase	Capsule, Delayed Release	022210	August 27, 2009	⤷ Get Started Free	2038-01-30
Zenpep, Llc	ZENPEP	pancrelipase	Capsule, Delayed Release	022210	June 15, 2011	⤷ Get Started Free	2038-01-30
Zenpep, Llc	ZENPEP	pancrelipase	Capsule, Delayed Release	022210	July 13, 2011	⤷ Get Started Free	2038-01-30
Zenpep, Llc	ZENPEP	pancrelipase	Capsule, Delayed Release	022210	March 25, 2014	⤷ Get Started Free	2038-01-30
Zenpep, Llc	ZENPEP	pancrelipase	Capsule, Delayed Release	022210	October 27, 2023	⤷ Get Started Free	2038-01-30
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 10,398,681

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Country	Patent Number	Estimated Expiration
World Intellectual Property Organization (WIPO)	2014100227	⤷ Get Started Free
United States of America	9913826	⤷ Get Started Free
United States of America	9642838	⤷ Get Started Free
United States of America	9169214	⤷ Get Started Free
United States of America	2025186399	⤷ Get Started Free
>Country	>Patent Number	>Estimated Expiration

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