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Last Updated: April 2, 2026

Claims for Patent: 10,357,573

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Summary for Patent: 10,357,573

Title:	Block copolymer conjugate of physiologically active substance
Abstract:	A physiologically active substance-conjugated block copolymer having enhanced efficacy and/or safety is provided by enhancing the property of penetrating into a target diseased tissue and/or enhancing excretability, compared to known physiologically active substance-conjugated block copolymer, and suppressing sensitization of the physiologically active substance to normal tissues other than a target diseased tissue. Disclosed is a block copolymer including a polyethylene glycol segment connected with a polyamino acid derivative segment conjugated with a physiologically active substance, in which the molecular weight of the block copolymer is from 2 kilodaltons to 15 kilodaltons, and the light scattering intensity of a 1 mg/mL aqueous solution of the physiologically active substance-conjugated block copolymer as measured with a laser light scattering photometer is at least twice or more the light scattering intensity of toluene.
Inventor(s):	Onda Takeshi, Masuda Akira, Yamakawa Ken, Tomiyama Chisato, Yoneta Yasushi, Akatsu Yuichi, Yamamoto Keiichirou, Mochizuki Ayaka
Assignee:	Nippon Kayaku Kabushiki Kaisha
Application Number:	US15548259
Patent Claims:

Details for Patent 10,357,573

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Nielsen Bioscience, Inc	CANDIN	candida albicans skin test antigen for cellular hypersensitivity	Injection	103257	November 27, 1995	10,357,573	2036-02-19
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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