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Last Updated: December 31, 2025

Claims for Patent: 10,336,983

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Summary for Patent: 10,336,983

Title:	Method for increasing the specific production rate of eukaryotic cells
Abstract:	The current invention reports the use of meta-tyrosine for increasing the specific productivity of a eukaryotic cell that produces/expresses a polypeptide. In the current method it is not necessary to perform a temperature-, osmolality- or pH shift or to add drugs like valproic acid or sodium butyrate to modulate the specific productivity of the cultivated cells. The method does not affect cell viability or product titer.
Inventor(s):	Popp Oliver
Assignee:	Hoffmann-La Roche Inc.
Application Number:	US15428279
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for patent 10,336,983

Details for Patent 10,336,983

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Idec Pharmaceuticals Corp.	RITUXAN	rituximab	Injection	103737	February 19, 2002	⤷ Get Started Free	2037-02-09
Genentech, Inc.	AVASTIN	bevacizumab	Injection	125085	February 26, 2004	⤷ Get Started Free	2037-02-09
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 10,336,983

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Country	Patent Number	Estimated Expiration
World Intellectual Property Organization (WIPO)	2016023775	⤷ Get Started Free
United States of America	2023081499	⤷ Get Started Free
United States of America	2020080048	⤷ Get Started Free
>Country	>Patent Number	>Estimated Expiration

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