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Last Updated: April 26, 2024

Claims for Patent: 10,272,118

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Summary for Patent: 10,272,118

Title:	Compositions and methods for treating and repairing tendons
Abstract:	The present invention relates to compositions and methods utilizing hair follicle derived Non-Bulbar Dermal Sheath cells for use in the treatment or prevention of the tendon injuries.
Inventor(s):	Hoffmann; Rolf (Freiburg, DE), McElwee; Kevin John (Vancouver, CA)
Assignee:	RepliCel Life Sciences Inc. (Vancouver, CA)
Application Number:	14/767,577
Patent Claims:	1. A method for treating a tendon injury, comprising administering to a subject in need thereof a composition comprising isolated non-bulbar dermal sheath (NBDS) cells; where the isolated NBDS cells were produced by a method comprising (a) preparing vital hair; (b) cleaving the vital hair prepared in step (a) to remove the hair follicle bulb and obtain an isolated dermal sheath; (c) isolating NBDS tissue from the dermal sheath produced in step (b); and (d) cultivating the isolated NBDS tissue of step (c) to produce the isolated NBDS cells. 2. The method according to claim 1 wherein said subject is a mammal selected from the group consisting of humans, horses, dogs and cats. 3. The method according to claim 1 wherein said tendon injury is selected from a complete tendon rupture, a partial tendon rupture, and a micro-tear of a tendon. 4. The method according to claim 1 wherein said tendon injury is selected from the group consisting of tendinosis, tenosynovitis, and avulsion. 5. The method according to claim 1 wherein said tendon is the Achilles tendon or the Patellar tendon. 6. The method according to claim 1 wherein said tendon is a flexor tendon. 7. The method according to claim 1 wherein said tendon is an extensor tendon. 8. The method according to claim 1 wherein said vital hair is obtained by biopsy from the occipital scalp of a subject. 9. The method according to claim 1 wherein said vital hair is cleaved utilizing a micromanipulator and scalpel. 10. The method according to claim 1 wherein producing the isolated NBDS cells comprises conducting enzymatic digestion of the isolated Non-Bulbar Dermal Sheath tissue. 11. The method according to claim 10 wherein said enzymatic digestion is conducted with collagenase. 12. The method according to claim 1 wherein said isolated NBDS cells are cultivated over multiple passages in either serum containing or serum-free media. 13. The method according to claim 1 wherein the composition further comprises at least one of serum and plasma. 14. The method according to claim 1 wherein the composition does not contain either serum or plasma. 15. The method according to claim 1 wherein the composition further comprises at least one component selected from the group consisting of fibrin, hyaluronic acid, a component of the extracellular matrix, cytokine, chemokine and therapeutic agent. 16. The method according to claim 15 wherein said component of the extracellular matrix is selected from the group consisting of glycosaminoglycan (GAG), heparin sulfate, chondroitin sulfate, keratin sulfate, hyaluronic acid, elastin, fibronectin and laminin. 17. The method according to claim 15 wherein said therapeutic agent is selected from the group consisting of analgesic agent, anti-inflammatory agent and immunomodulatory agent.

Details for Patent 10,272,118

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Smith & Nephew, Inc.	SANTYL	collagenase	Ointment	101995	06/04/1965	⤷ Try a Trial	2033-02-12
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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