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Last Updated: January 20, 2021

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Claims for Patent: 10,265,374

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Summary for Patent: 10,265,374
Title:Occidiofungin formations and uses thereof
Abstract: Disclosed are occidiofungin formulations and uses thereof for the treatment of proliferative disorders, such as cancer. Methods of producing the disclosed occidiofungin formulations are also provided. Further, methods of treating a subject with the formulations are provided. In some embodiments, the formulations include occidiofungin and one or more cyclodextrins. The formulations may optionally further comprise an additional chemotherapeutic agent for treating the proliferative disease, lipid vesicles, and/or aqueous solvents (including pharmaceutically acceptable buffers and/or exceipients).
Inventor(s): Smith; James L. (College Station, TX), Pruett; Stephen (Starkville, MS), Austin; Frank (Starkville, MS), Lu; Shien (Starkville, MS), Akshaya; Ravichandran (Bryan, TX), Laihing; Steven (College Station, TX)
Assignee: MISSISSIPPI STATE UNIVERSITY (Starkville, MS) THE TEXAS A&M UNIVERSITY SYSTEM (College Station, TX)
Application Number:15/510,801
Patent Claims:1. A formulation comprising occidiofungin, and one or more cyclodextrins and an aqueous solvent, wherein either a) said occidiofungin is present in an amount ranging from about 20 .mu.g/mL to about 1 g/mL; or b) said one or more cyclodextrins comprise between about 0.5% to about 10% weight/volume (w/v) of said formulation.

2. The formulation according to claim 1, wherein said occidiofungin is present in an amount ranging from about 20 .mu.g/mL to about 1 g/mL.

3. The formulation according to claim 1, wherein said one or more cyclodextrins comprise between about 0.5% to about 10% weight/volume (w/v) of said formulation.

4. The formulation according to claim 1, wherein said one or more cyclodextrins is selected from the group consisting of .alpha.-cyclodextrin, .beta.-cyclodextrin, .gamma.-cyclodextrin, cyclomaltonose, variants thereof, and any combination thereof.

5. The formulation according to claim 1, wherein said one or more cyclodextrins is selected from the group consisting of hydroxypropyl-.beta.-cyclodextrin, sulfobutylether-.beta.-cyclodextrin, hydroxyethyl .beta.-cyclodextrin, methyl-.beta.-cyclodextrin, dimethyl-.beta.-cyclodextrin, randomly dimethylated-.beta.-cyclodextrin, randomly methylated-.beta.-cyclodextrin, carboxymethyl-.beta.-cyclodextrin, carboxymethyl ethyl-.beta.-cyclodextrin, diethyl-.beta.-cyclodextrin, tri-O-methyl-.beta.-cyclodextrin, tri-O-ethyl-.beta.-cyclodextrin, tri-O-butyryl-.beta.-cyclodextrin, tri-O-valeryl-.beta.-cyclodextrin, di-O-hexanoyl-.beta.-cyclodextrin, glucosyl-.beta.-cyclodextrin, maltosyl-.beta.-cyclodextrin, and 2-hydroxy-3-trimethyl-ammoniopropyl-.beta.-cyclodextrin, or combinations thereof.

6. The formulation according to claim 1, wherein said one or more cyclodextrins is hydroxypropyl-.beta.-cyclodextrin.

7. The formulation according to claim 1, further comprising lipid vesicles.

8. The formulation according to claim 7, wherein said lipid vesicles comprise lipids selected from the group consisting of 1,2-Dioleoyl-sn-glycero-3-phosphocholine, 1,2-dipalmitoyl-sn-glycero-3-[phospho-rac-(3-lysyl(1-glycerol))], and combinations thereof.

9. The formulation according to claim 1, wherein said aqueous solvent is a pharmaceutically acceptable buffer, excipient, or combination thereof.

10. The formulation according to claim 9, wherein said pharmaceutically acceptable buffer, excipient, or combination thereof is selected from the group consisting of Ringer's solution, isotonic saline, isotonic glucose solutions, distilled water, and phosphate buffered saline.

11. The formulation according to claim 1, further comprising at least one chemotherapeutic agent.

12. The formulation according to claim 11, wherein said at least one chemotherapeutic agent is selected from the group consisting of: analogs of gonadotropin releasing hormone; nitrosoureas, 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloroethyl)-3-nitrosourea (ACNU), 1,3-bis (2-chloroethyl)-1-nitroso-urea (BCNU), 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU), N-hydroxyethylnitroso-N'-chloroethylurea (HCNU); cytostatic antibiotics, doxorubicin, pegylated liposomal doxorubicin, 5-fluorodeoxyuridine, 5-fluoro-2'-deoxyuridine 5'-monophosphate (5-FdUMP), 5-fluorouracil, 5-fluorouridine, procarbazine, docetaxel, gemcitabine, gemcitabine hydrochloride, telozolomide, epirubicin, epirubicin hydrochloride, idarubicin hydrochloride, zorubicin hydrochloride, aclarubicin, amrubicin, nemorubicin, pirarubicin; vinca alkaloids, vinblastine, vincristine, vindesine; and acivicin, acodazole hydrochloride, acronine, ambomycin, ametantrone acetate, aminoglutethimide, anthramycin, asparaginase, asperlin, bevacizumab (Avastin.TM.), azacitidine, azetepa, azotomycin, benzodepa, bisantrene hydrochloride, bisnafide dimesylate, bleomycin sulfate, brequinar sodium, busulfan, cactinomycin, calusterone, caracemide, carbetimer, carboplatin, carmustine, carubicin hydrochloride, cedefingol, cetuximab, chlorambucil, cirolemycin, cisplatin, crisnatol mesylate, cyclophosphamide, cytarabine, dacarbazine, N-[2-(dimethyl-amino)ethyl]acridine-4-carboxamide (DACA), dactinomycin, daunomycin, dexormaplatin, dezaguanine, dezaguanine mesylate, droloxifene citrate, dromostanolone propionate, duazomycin, edatrexate, eflornithine hydrochloride, elsamitrucin, enloplatin, enpromate, epipropidine, erbulozole, erlotinib, esorubicin hydrochloride, estramustine, estramustine phosphate sodium, ethiodized oil I.sup.131, etoposide phosphate, etoprine, fadrozole hydrochloride, fludarabine phosphate, flurocitabine, fosquidone, fostriecin sodium, gefitinib (Iressa.TM.), gold (Au) 198, hydroxyurea, ifosfamide, imatinib mesylate, interferon alfa-2a, interferon alfa-2b, interferon alfa-n1, interferon alfa-n3, interferon beta-I a, interferon gamma-I b, iproplatin, irinotecan hydrochloride, lanreotide acetate, leuprolide acetate, liarozole hydrochloride, lometrexol sodium, lomustine, losoxantrone hydrochloride, maytansine, mechlorethamine hydrochloride, megestrol acetate, melengestrol acetate, melphalan, mercaptopurine, methotrexate, methotrexate sodium, metoprine, meturedepa, mitindomide, mitocarcin, mitocromin, mitogillin, mitomalcin, mitomycin, mitosper, mitotane, mitoxantrone hydrochloride, mycophenolic acid, nocodazole, nogalamycin, oxisuran, paclitaxel, peliomycin, pentamustine, peplomycin sulfate, pipobroman, piposulfan, piroxantrone hydrochloride, plicamycin, plomestane, prednimustine, procarbazine hydrochloride, puromycin, puromycin hydrochloride, pyrazofurin, riboprine, rituximab, safinol, safingol hydrochloride, simtrazene, sparfosate sodium, sparsomycin, spirogermanium hydrochloride, spiromustine, spiroplatin, streptonigrin, streptozocin, strontium 89 (Sr) chloride, sulofenur, talisomycin, tamoxifen, taxane, taxoid, teloxantrone hydrochloride, teroxirone, testolactone, thiamiprine, thioguanine, thiotepa, nolatrexed (Thymitaq.TM.), tiazofurin, raltitrexed (Tomudex.TM.), 4beta-aminoalkyl-4'-O-demethyl-4-desoxypodophyllotoxin (TOP-53), topotecan hydrochloride: toremifene citrate, trastuzumab, trestolone acetate, triciribine phosphate, trimetrexate, trimetrexate glucuronate, tubulozole hydrochloride, uracil mustard, uredepa, vinblastine sulfate, vincristine sulfate, vindesine sulfate, vinepidine sulfate, vinglycinate sulfate, vinleurosine sulfate, vinorelbine tartrate, vinrosidine sulfate, vinzolidine sulfate, zeniplatin, zinostatin, 2-chlorodeoxyadenosine, 2'-deoxformycin, 9-aminocamptothecin, raltitrexed, N-propargyl-5,8-dideazafolic acid, 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine, 2-chloro-2'-deoxyadenosine, anisomycin, trichostatin A, hPRL-G129R, CEP-751, linomide, 20-epi-1,25 dihydroxyvitamin D3, 5-ethynyluracil, abiraterone, acylfulvene, adecypenol, adozelesin, aldesleukin, ALL-tyrosine kinase (TK) antagonists, altretamine, ambamustine, amidox, amifostine, aminolevulinic acid, amsacrine, anagrelide, anastrozole, andrographolide, antagonist D, antagonist G, teverelix (Antarelix.TM.), anti-dorsalizing morphogenetic protein-1, antineoplaston, aphidicolin glycinate, apoptosis gene modulators, apoptosis regulators, apurinic acid, 1-beta-D-Arabinofuranosylcytosine 5'-diphosphate-rac-1-S-octadecyl-2-O-palmitoyl-1-thioglycerol (ara-CDP-DL-PTBA), arginine deaminase, asulacrine, atamestane, atrimustine, axinastatin 1, axinastatin 2, axinastatin 3, azasetron, azatoxin, azatyrosine, baccatin III derivatives, balanol, batimastat, breakpoint cluster region/abelson murine leukemia viral oncogene homolog 1 (BCR/ABL) antagonists, benzochlorins, benzoylstaurosporine, beta lactam derivatives, beta-alethine, betaclamycin B, betulinic acid, basic fibroblast growth factor (bFGF) inhibitor, bicalutamide, bisaziridinylspermine, bisnafide, bistratene A, bizelesin, breflate, bropirimine, budotitane, buthionine sulfoximine, calcipotriol, calphostin C, camptothecin derivatives, canarypox IL-2, capecitabine, carboxamide-amino-triazole, carboxyamidotriazole, CaRest M3.TM., CARN 700, carzelesin, castanospermine, cecropin B, cetrorelix, chlorins, chloroquinoxaline sulfonamide, cicaprost, cis-porphyrin, cladribine, clomifene analogues, clotrimazole, collismycin A, collismycin B, combretastatin A4, combretastatin analogue, conagenin, crambescidin 816, crisnatol, cryptophycin 8, curacin A, cyclopentanthraquinones, cycloplatam, cypemycin, cytarabine ocfosfate, cytolytic factor, cytostatin, dacliximab, decitabine, dehydrodidemnin B, deslorelin, dexifosfamide, dexrazoxane, dexverapamil, diaziquone, didemnin B, didox, diethylnorspermine, dihydro-5-azacytidine, dihydrotaxol, 9-dihydrotaxol, dioxamycin, diphenyl spiromustine, discodermolide, docosanol, dolasetron, doxifluridine, droloxifene, dronabinol, duocarmycin SA, ebselen, ecomustine, edelfosine, edrecolomab, eflornithine, elemene, emitefur, epothilones, desoxyepothilones (A and B), epithilones, epristeride, estramustine analogue, estrogen agonists, estrogen antagonists, androgen antagonists, etanidazole, etoposide, etoposide 4'-phosphate, exemestane, fadrozole, fazarabine, fenretinide, filgrastim, finasteride, flavopiridol, flezelastine, fluasterone, fludarabine, fluorodaunorunicin hydrochloride, forfenimex, formestane, fostriecin, fotemustine, gadolinium texaphyrin, gallium nitrate, galocitabine, gelatinase inhibitors, glutathione inhibitors, hepsulfam, heregulin, hexamethylene bisacetamide, hypericin, ibandronic acid, idarubicin, idoxifene, idramantone, ilmofosine, ilomastat, imidazoacridones, imiquimod, immunostimulant peptides, insulin-like growth factor-1 receptor inhibitor, interferon agonists, iobenguane, iododoxorubicin, 4-ipomeanol, irinotecan, iroplact, irsogladine, isobengazole, isohomohalicondrin B, itasetron, jasplakinolide, kahalalide F, lamellarin-N triacetate, lanreotide, leinamycin, lenograstim, lentinan sulfate, leptolstatin, letrozole, leukocyte alpha interferon, leuprolide+estrogen+progesterone, leuprorelin, levamisole, liarozole, lipophilic platinum compounds, lissoclinamide 7, lobaplatin, lombricine, lometrexol, lonidamine, losoxantrone, lovastatin, loxoribine, lurtotecan, lutetium texaphyrin, lysofylline, maitansine, mannostatin A, marimastat, masoprocol, matrilysin inhibitors, matrix metalloproteinase inhibitors, menogaril, merbarone, 2-Me-D-Trp(6),desgly(10)-lhrh ethylamide (Meterelin.TM.), methioninase, metoclopramide, macrophage migration inhibitory factor (MIF) inhibitor, mifepristone, miltefosine, mirimostim, plicamycin (Mithracin.TM.), mitoguazone, mitolactol, mitomycin analogues, mitonafide, mitotoxin fibroblast growth factor-saporin, mitoxantrone, mofarotene, molgramostim, monophosphoryl lipid A+myobacterium cell wall SK, mopidamol, mustard anticarcinoma agents, mycaperoxide B, myriaporone, N-acetyldinaline, N-substituted benzamides, nafarelin, nagrestip, naloxone+pentazocine, napavin, naphterpin, nartograstim, nedaplatin, neridronic acid, nilutamide, nisamycin, nitric oxide modulators, nitroxide antioxidant, nitrullyn, O6-benzylguanine, octreotide, okicenone, onapristone, ondansetron, oracin, ormaplatin, osaterone, oxaliplatin, oxaunomycin, paclitaxel analogues, paclitaxel derivatives, palauamine, palmitoylrhizoxin, pamidronic acid, panaxytriol, panomifene, parabactin, pazelliptine, pegaspargase, peldesine, pentosan polysulfate sodium, pentostatin, pentrozole, perflubron, perfosfamide, perillyl alcohol, phenazinomycin, phenylacetate, picibanil, pilocarpine hydrochloride, piritrexim, placetin A, placetin B, plasminogen activator inhibitor, platinum-triamine complex, podophyllotoxin, porfimer sodium, porfiromycin, propyl bis-acridone, prostaglandin J2, protein A-based immune modulator, protein kinase C inhibitors, microalgal, protein tyrosine phosphatase inhibitors, purine nucleoside phosphorylase inhibitors, purpurins, pyrazoloacridine, pyridoxylated hemoglobin polyoxyethylene conjugate, raf antagonists, ramosetron, ras farnesyl protein transferase inhibitors, ras inhibitors, ras-GAP inhibitor, retelliptine demethylated, rhenium (Re) 186 etidronate, rhizoxin, RII retinamide, rogletimide, rohitukine, romurtide, roquinimex, rubiginone B1, ruboxyl, safingol, saintopin, 2-chloroethyl-3-sarcosinamide-1-nitrosourea (SarCNU), sarcophytol A, sargramostim, Sdi 1 mimetics, semustine, senescence derived inhibitor 1, sizofiran, sobuzoxane, sodium borocaptate, sodium phenylacetate, solverol, sonermin, sparfosic acid, spicamycin D, splenopentin, spongistatin 1, squalamine, stipiamide, stromelysin inhibitors, sulfinosine, superactive vasoactive intestinal peptide antagonist, suradista, suramin, swainsonine, synthetic glycosaminoglycans, tallimustine, tamoxifen methiodide, tauromustine, tazarotene, tecogalan sodium, tegafur, tellurapyrylium, telomerase inhibitors, temoporfin, temozolomide, teniposide, tetrachlorodecaoxide, tetrazomine, thaliblastine, thalidomide, thiocoraline, thrombopoietin, thrombopoietin mimetic, thymalfasin, thymopoietin receptor agonist, thymotrinan, thyroid stimulating hormone, tin ethyl etiopurpurin, tirapazamine, titanocene dichloride, topotecan, topsentin, toremifene, totipotent stem cell factor, tretinoin, triacetyluridine, triciribine, triptorelin, tropisetron, turosteride, tyrphostins, ubiquitin C (UBC) inhibitors, ubenimex, urogenital sinus-derived growth inhibitory factor, urokinase receptor antagonists, vapreotide, variolin B, velaresol, veramine, verdins, verteporfin, vinorelbine, vinxaltine, vitaxin, vorozole, and combinations thereof.

13. The formulation according to claim 11, wherein said at least one chemotherapeutic agent is selected from the group consisting of: analogs of gonadotropin releasing hormone; nitrosoureas, 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloroethyl)-3-nitrosourea (ACNU), 1,3-bis (2-chloroethyl)-1-nitroso-urea (BCNU), 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU), N-hydroxyethylnitroso-N'-chloroethylurea (HCNU); cytostatic antibiotics, doxorubicin, pegylated liposomal doxorubicin, 5-fluorodeoxyuridine, 5-fluoro-2'-deoxyuridine 5'-monophosphate (5-FdUMP), 5-fluorouracil, 5-fluorouridine, procarbazine, docetaxel, gemcitabine, gemcitabine hydrochloride, telozolomide; vinca alkaloids, vinblastine, vincristine, vindesine; and acivicin, acodazole hydrochloride, acronine, ambomycin, ametantrone acetate, aminoglutethimide, anthramycin, asparaginase, asperlin, bevacizumab (Avastin.TM.), azacitidine, azetepa, azotomycin, benzodepa, bisantrene hydrochloride, bisnafide dimesylate, bleomycin sulfate, brequinar sodium, busulfan, cactinomycin, calusterone, caracemide, carbetimer, carboplatin, carmustine, carubicin hydrochloride, cedefingol, cetuximab, chlorambucil, cirolemycin, cisplatin, crisnatol mesylate, cyclophosphamide, cytarabine, dacarbazine, N-[2-(dimethyl-amino)ethyl]acridine-4-carboxamide (DACA), dactinomycin, daunomycin, dexormaplatin, dezaguanine, dezaguanine mesylate, droloxifene citrate, dromostanolone propionate, duazomycin, edatrexate, eflornithine hydrochloride, elsamitrucin, enloplatin, enpromate, epipropidine, epirubicin hydrochloride, erbulozole, erlotinib, esorubicin hydrochloride, estramustine, estramustine phosphate sodium, ethiodized oil I.sup.131, etoposide phosphate, etoprine, fadrozole hydrochloride, fludarabine phosphate, flurocitabine, fosquidone, fostriecin sodium, gefitinib (Iressa.TM.), gold (Au) 198, hydroxyurea, idarubicin hydrochloride, ifosfamide, imatinib mesylate, interferon alfa-2a, interferon alfa-2b, interferon alfa-n1, interferon alfa-n3, interferon beta-I a, interferon gamma-I b, iproplatin, irinotecan hydrochloride, lanreotide acetate, leuprolide acetate, liarozole hydrochloride, lometrexol sodium, lomustine, losoxantrone hydrochloride, maytansine, mechlorethamine hydrochloride, megestrol acetate, melengestrol acetate, melphalan, mercaptopurine, methotrexate, methotrexate sodium, metoprine, meturedepa, mitindomide, mitocarcin, mitocromin, mitogillin, mitomalcin, mitomycin, mitosper, mitotane, mitoxantrone hydrochloride, mycophenolic acid, nocodazole, nogalamycin, oxisuran, paclitaxel, peliomycin, pentamustine, peplomycin sulfate, pipobroman, piposulfan, piroxantrone hydrochloride, plicamycin, plomestane, prednimustine, procarbazine hydrochloride, puromycin, puromycin hydrochloride, pyrazofurin, riboprine, rituximab, safinol, safingol hydrochloride, simtrazene, sparfosate sodium, sparsomycin, spirogermanium hydrochloride, spiromustine, spiroplatin, streptonigrin, streptozocin, strontium (Sr) chloride 89, sulofenur, talisomycin, tamoxifen, taxane, taxoid, teloxantrone hydrochloride, teroxirone, testolactone, thiamiprine, thioguanine, thiotepa, nolatrexed (Thymitaq.TM.), tiazofurin, raltitrexed (Tomudex.TM.), 4beta-aminoalkyl-4'-O-demethyl-4-desoxypodophyllotoxin (TOP-53), topotecan hydrochloride: toremifene citrate, trastuzumab, trestolone acetate, triciribine phosphate, trimetrexate, trimetrexate glucuronate, tubulozole hydrochloride, uracil mustard, uredepa, vinblastine sulfate, vincristine sulfate, vindesine sulfate, vinepidine sulfate, vinglycinate sulfate, vinleurosine sulfate, vinorelbine tartrate, vinrosidine sulfate, vinzolidine sulfate, zeniplatin, zinostatin, zorubicin hydrochloride, 2-chlorodeoxyadenosine, 2'-deoxformycin, 9-aminocamptothecin, raltitrexed, N-propargyl-5,8-dideazafolic acid, 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine, 2-chloro-2'-deoxyadenosine, anisomycin, trichostatin A, hPRL-G129R, CEP-751, linomide, 20-epi-1,25 dihydroxyvitamin D3, 5-ethynyluracil, abiraterone, aclarubicin, acylfulvene, adecypenol, adozelesin, aldesleukin, ALL-tyrosine kinase (TK) antagonists, altretamine, ambamustine, amidox, amifostine, aminolevulinic acid, amrubicin, amsacrine, anagrelide, anastrozole, andrographolide, antagonist D, antagonist G, teverelix (Antarelix.TM.), anti-dorsalizing morphogenetic protein-1, antineoplaston, aphidicolin glycinate, apoptosis gene modulators, apoptosis regulators, apurinic acid, 1-beta-D-Arabinofuranosylcytosine 5'-diphosphate-rac-1-S-octadecyl-2-O-palmitoyl-1-thioglycerol (ara-CDP-DL-PTBA), arginine deaminase, asulacrine, atamestane, atrimustine, axinastatin 1, axinastatin 2, axinastatin 3, azasetron, azatoxin, azatyrosine, baccatin III derivatives, balanol, batimastat, breakpoint cluster region/abelson murine leukemia viral oncogene homolog 1 (BCR/ABL) antagonists, benzochlorins, benzoylstaurosporine, beta lactam derivatives, beta-alethine, betaclamycin B, betulinic acid, basic fibroblast growth factor (bFGF) inhibitor, bicalutamide, bisaziridinylspermine, bisnafide, bistratene A, bizelesin, breflate, bropirimine, budotitane, buthionine sulfoximine, calcipotriol, calphostin C, camptothecin derivatives, canarypox IL-2, capecitabine, carboxamide-amino-triazole, carboxyamidotriazole, CaRest M3.TM., CARN 700, cartilage derived inhibitor, carzelesin, casein kinase inhibitors (ICOS), castanospermine, cecropin B, cetrorelix, chlorins, chloroquinoxaline sulfonamide, cicaprost, cis-porphyrin, cladribine, clomifene analogues, clotrimazole, collismycin A, collismycin B, combretastatin A4, combretastatin analogue, conagenin, crambescidin 816, crisnatol, cryptophycin 8, cryptophycin A derivatives, curacin A, cyclopentanthraquinones, cycloplatam, cypemycin, cytarabine ocfosfate, cytolytic factor, cytostatin, dacliximab, decitabine, dehydrodidemnin B, deslorelin, dexifosfamide, dexrazoxane, dexverapamil, diaziquone, didemnin B, didox, diethylnorspermine, dihydro-5-azacytidine, dihydrotaxol, 9-dihydrotaxol, dioxamycin, diphenyl spiromustine, discodermolide, docosanol, dolasetron, doxifluridine, droloxifene, dronabinol, duocarmycin SA, ebselen, ecomustine, edelfosine, edrecolomab, eflornithine, elemene, emitefur, epirubicin, epothilones, desoxyepothilones (A and B), epithilones, epristeride, estramustine analogue, estrogen agonists, estrogen antagonists, androgen antagonists, etanidazole, etoposide, etoposide 4'-phosphate, exemestane, fadrozole, fazarabine, fenretinide, filgrastim, finasteride, flavopiridol, flezelastine, fluasterone, fludarabine, fluorodaunorunicin hydrochloride, forfenimex, formestane, fostriecin, fotemustine, gadolinium texaphyrin, gallium nitrate, galocitabine, gelatinase inhibitors, glutathione inhibitors, hepsulfam, heregulin, hexamethylene bisacetamide, hypericin, ibandronic acid, idarubicin, idoxifene, idramantone, ilmofosine, ilomastat, imidazoacridones, imiquimod, immunostimulant peptides, insulin-like growth factor-1 receptor inhibitor, interferon agonists, interferons, interleukins, iobenguane, iododoxorubicin, 4-ipomeanol, irinotecan, iroplact, irsogladine, isobengazole, isohomohalicondrin B, itasetron, jasplakinolide, kahalalide F, lamellarin-N triacetate, lanreotide, leinamycin, lenograstim, lentinan sulfate, leptolstatin, letrozole, leukemia inhibiting factor, leukocyte alpha interferon, leuprolide+estrogen+progesterone, leuprorelin, levamisole, liarozole, lipophilic platinum compounds, lissoclinamide 7, lobaplatin, lombricine, lometrexol, lonidamine, losoxantrone, lovastatin, loxoribine, lurtotecan, lutetium texaphyrin, lysofylline, maitansine, mannostatin A, marimastat, masoprocol, matrilysin inhibitors, matrix metalloproteinase inhibitors, menogaril, merbarone, 2-Me-D-Trp(6),desgly(10)-lhrh ethylamide (Meterelin.TM.), methioninase, metoclopramide, macrophage migration inhibitory factor (MIF) inhibitor, mifepristone, miltefosine, mirimostim, plicamycin (Mithracin.TM.), mitoguazone, mitolactol, mitomycin analogues, mitonafide, mitotoxin fibroblast growth factor-saporin, mitoxantrone, mofarotene, molgramostim, monoclonal antibody, human chorionic gonadotrophin, monophosphoryl lipid A+myobacterium cell wall SK, mopidamol, multiple drug resistance gene inhibitor, mustard anticarcinoma agents, mycaperoxide B, mycobacterial cell wall extract, myriaporone, N-acetyldinaline, N-substituted benzamides, nafarelin, nagrestip, naloxone+pentazocine, napavin, naphterpin, nartograstim, nedaplatin, nemorubicin, neridronic acid, neutral endopeptidase, nilutamide, nisamycin, nitric oxide modulators, nitroxide antioxidant, nitrullyn, O6-benzylguanine, octreotide, okicenone, onapristone, ondansetron, oracin, ormaplatin, osaterone, oxaliplatin, oxaunomycin, paclitaxel analogues, paclitaxel derivatives, palauamine, palmitoylrhizoxin, pamidronic acid, panaxytriol, panomifene, parabactin, pazelliptine, pegaspargase, peldesine, pentosan polysulfate sodium, pentostatin, pentrozole, perflubron, perfosfamide, perillyl alcohol, phenazinomycin, phenyl acetate, phosphatase inhibitors, picibanil, pilocarpine hydrochloride, pirarubicin, piritrexim, placetin A, placetin B, plasminogen activator inhibitor, platinum-triamine complex, podophyllotoxin, porfimer sodium, porfiromycin, propyl bis-acridone, prostaglandin J2, proteasome inhibitors, protein A-based immune modulator, protein kinase C inhibitors, microalgal, protein tyrosine phosphatase inhibitors, purine nucleoside phosphorylase inhibitors, purpurins, pyrazoloacridine, pyridoxylated hemoglobin polyoxyethylene conjugate, raf antagonists, ramosetron, ras farnesyl protein transferase inhibitors, ras inhibitors, ras-GAP inhibitor, retelliptine demethylated, rhenium (Re) 186 etidronate, rhizoxin, ribozymes, RH retinamide, rogletimide, rohitukine, romurtide, roquinimex, rubiginone B1, ruboxyl, safingol, saintopin, 2-chloroethyl-3-sarcosinamide-1-nitrosourea (SarCNU), sarcophytol A, sargramostim, Sdi 1 mimetics, semustine, senescence derived inhibitor 1, single chain antigen binding protein, sizofiran, sobuzoxane, sodium borocaptate, sodium phenylacetate, solverol, somatomedin binding protein, sonermin, sparfosic acid, spicamycin D, splenopentin, spongistatin 1, squalamine, stipiamide, stromelysin inhibitors, sulfinosine, superactive vasoactive intestinal peptide antagonist, suradista, suramin, swainsonine, synthetic glycosaminoglycans, tallimustine, tamoxifen methiodide, tauromustine, tazarotene, tecogalan sodium, tegafur, tellurapyrylium, telomerase inhibitors, temoporfin, temozolomide, teniposide, tetrachlorodecaoxide, tetrazomine, thaliblastine, thalidomide, thiocoraline, thrombopoietin, thrombopoietin mimetic, thymalfasin, thymopoietin receptor agonist, thymotrinan, thyroid stimulating hormone, tin ethyl etiopurpurin, tirapazamine, titanocene dichloride, topotecan, topsentin, toremifene, totipotent stem cell factor, tretinoin, triacetyluridine, triciribine, triptorelin, tropisetron, turosteride, tyrosine kinase inhibitors, tyrphostins, ubiquitin C (UBC) inhibitors, ubenimex, urogenital sinus-derived growth inhibitory factor, urokinase receptor antagonists, vapreotide, variolin B, velaresol, veramine, verdins, verteporfin, vinorelbine, vinxaltine, vitaxin, vorozole, and combinations thereof.

14. A method of formulating an occidiofungin formulation comprising combining occidiofungin with one or more cyclodextrins and an aqueous solvent, wherein said occidiofungin formulation comprises either a) said occidiofungin in an amount ranging from about 20 .mu.g/mL to about 1 g/mL; or b) said one or more cyclodextrins at between about 0.5% to about 10% weight/volume (w/v) of said formulation.

15. The method according to claim 14, wherein said occidiofungin formulation comprises between about 0.5% to about 10% weight/volume (w/v) of said one or more cyclodextrins.

16. The method according to claim 14, wherein said occidiofungin formulation comprises said occidiofungin is present in an amount ranging from about 20 .mu.g/mL to about 1 g/mL.

17. The method according to claim 14, wherein said one or more cyclodextrin is selected from the group consisting of .alpha.-cyclodextrin, .beta.-cyclodextrin, .gamma.-cyclodextrin, cyclomaltonose, variants thereof, and any combination thereof.

18. The method according to claim 14, wherein said one or more cyclodextrin is selected from the group consisting of hydroxypropyl-.beta.-cyclodextrin, sulfobutylether-.beta.-cyclodextrin, hydroxyethyl .beta.-cyclodextrin, methyl-.beta.-cyclodextrin, dimethyl-.beta.-cyclodextrin, randomly dimethylated-.beta.-cyclodextrin, randomly methylated-.beta.-cyclodextrin, carboxymethyl-.beta.-cyclodextrin, carboxymethyl ethyl-.beta.-cyclodextrin, diethyl-.beta.-cyclodextrin, tri-O-methyl-.beta.-cyclodextrin, tri-O-ethyl-3-cyclodextrin, tri-O-butyryl-3-cyclodextrin, tri-O-valeryl-3-cyclodextrin, di-O-hexanoyl-.beta.-cyclodextrin, glucosyl-.beta.-cyclodextrin, maltosyl-.beta.-cyclodextrin, and 2-hydroxy-3-trimethyl-ammoniopropyl-.beta.-cyclodextrin, or combinations thereof.

19. The method according to claim 14, wherein said one or more cyclodextrin is hydroxypropyl-.beta.-cyclodextrin.

20. The method according to claim 14, further comprising combining lipid vesicles with said occidiofungin formulation.

21. The method according to claim 20, wherein said lipid vesicles comprise lipids selected from the group consisting of 1,2-Dioleoyl-sn-glycero-3-phosphocholine, 1,2-dipalmitoyl-sn-glycero-3-[phospho-rac-(3-lysyl(1-glycerol))], and combinations thereof.

22. The method according to claim 14, wherein said aqueous solvent is a pharmaceutically acceptable buffer, excipient, or combination thereof.

23. The method according to claim 22, wherein said pharmaceutically acceptable buffer, excipient, or combination thereof is selected from the group consisting of Ringer's solution, isotonic saline, isotonic glucose solutions, distilled water, and phosphate buffered saline.

24. The method according to claim 14, further comprising adding one or more chemotherapeutic agents to said occidiofungin formulation.

25. The method according to claim 24, wherein said one or more chemotherapeutic agents are selected from the group consisting of: analogs of gonadotropin releasing hormone; nitrosoureas, 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloroethyl)-3-nitrosourea (ACNU), 1,3-bis (2-chloroethyl)-1-nitroso-urea (BCNU), 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU), N-hydroxyethylnitroso-N'-chloroethylurea (HCNU); cytostatic antibiotics, doxorubicin, pegylated liposomal doxorubicin, 5-fluorodeoxyuridine, 5-fluoro-2'-deoxyuridine 5'-monophosphate (5-FdUMP), 5-fluorouracil, 5-fluorouridine, procarbazine, docetaxel, gemcitabine, gemcitabine hydrochloride, telozolomide, epirubicin, epirubicin hydrochloride, idarubicin hydrochloride, zorubicin hydrochloride, aclarubicin, amrubicin, nemorubicin, pirarubicin; vinca alkaloids, vinblastine, vincristine, vindesine; and acivicin, acodazole hydrochloride, acronine, ambomycin, ametantrone acetate, aminoglutethimide, anthramycin, asparaginase, asperlin, bevacizumab (Avastin.TM.), azacitidine, azetepa, azotomycin, benzodepa, bisantrene hydrochloride, bisnafide dimesylate, bleomycin sulfate, brequinar sodium, busulfan, cactinomycin, calusterone, caracemide, carbetimer, carboplatin, carmustine, carubicin hydrochloride, cedefingol, cetuximab, chlorambucil, cirolemycin, cisplatin, crisnatol mesylate, cyclophosphamide, cytarabine, dacarbazine, N-[2-(dimethyl-amino)ethyl]acridine-4-carboxamide (DACA), dactinomycin, daunomycin, dexormaplatin, dezaguanine, dezaguanine mesylate, droloxifene citrate, dromostanolone propionate, duazomycin, edatrexate, eflornithine hydrochloride, elsamitrucin, enloplatin, enpromate, epipropidine, erbulozole, erlotinib, esorubicin hydrochloride, estramustine, estramustine phosphate sodium, ethiodized oil I.sup.131, etoposide phosphate, etoprine, fadrozole hydrochloride, fludarabine phosphate, flurocitabine, fosquidone, fostriecin sodium, gefitinib (Iressa.TM.), gold (Au) 198, hydroxyurea, ifosfamide, imatinib mesylate, interferon alfa-2a, interferon alfa-2b, interferon alfa-n1, interferon alfa-n3, interferon beta-I a, interferon gamma-I b, iproplatin, irinotecan hydrochloride, lanreotide acetate, leuprolide acetate, liarozole hydrochloride, lometrexol sodium, lomustine, losoxantrone hydrochloride, maytansine, mechlorethamine hydrochloride, megestrol acetate, melengestrol acetate, melphalan, mercaptopurine, methotrexate, methotrexate sodium, metoprine, meturedepa, mitindomide, mitocarcin, mitocromin, mitogillin, mitomalcin, mitomycin, mitosper, mitotane, mitoxantrone hydrochloride, mycophenolic acid, nocodazole, nogalamycin, oxisuran, paclitaxel, peliomycin, pentamustine, peplomycin sulfate, pipobroman, piposulfan, piroxantrone hydrochloride, plicamycin, plomestane, prednimustine, procarbazine hydrochloride, puromycin, puromycin hydrochloride, pyrazofurin, riboprine, rituximab, safinol, safingol hydrochloride, simtrazene, sparfosate sodium, sparsomycin, spirogermanium hydrochloride, spiromustine, spiroplatin, streptonigrin, streptozocin, strontium 89 (Sr) chloride, sulofenur, talisomycin, tamoxifen, taxane, taxoid, teloxantrone hydrochloride, teroxirone, testolactone, thiamiprine, thioguanine, thiotepa, nolatrexed (Thymitaq.TM.), tiazofurin, raltitrexed (Tomudex.TM.), 4beta-aminoalkyl-4'-O-demethyl-4-desoxypodophyllotoxin (TOP-53), topotecan hydrochloride: toremifene citrate, trastuzumab, trestolone acetate, triciribine phosphate, trimetrexate, trimetrexate glucuronate, tubulozole hydrochloride, uracil mustard, uredepa, vinblastine sulfate, vincristine sulfate, vindesine sulfate, vinepidine sulfate, vinglycinate sulfate, vinleurosine sulfate, vinorelbine tartrate, vinrosidine sulfate, vinzolidine sulfate, zeniplatin, zinostatin, 2-chlorodeoxyadenosine, 2'-deoxformycin, 9-aminocamptothecin, raltitrexed, N-propargyl-5,8-dideazafolic acid, 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine, 2-chloro-2'-deoxyadenosine, anisomycin, trichostatin A, hPRL-G129R, CEP-751, linomide, 20-epi-1,25 dihydroxyvitamin D3, 5-ethynyluracil, abiraterone, acylfulvene, adecypenol, adozelesin, aldesleukin, ALL-tyrosine kinase (TK) antagonists, altretamine, ambamustine, amidox, amifostine, aminolevulinic acid, amsacrine, anagrelide, anastrozole, andrographolide, antagonist D, antagonist G, teverelix (Antarelix.TM.), anti-dorsalizing morphogenetic protein-1, antineoplaston, aphidicolin glycinate, apoptosis gene modulators, apoptosis regulators, apurinic acid, 1-beta-D-Arabinofuranosylcytosine 5'-diphosphate-rac-1-S-octadecyl-2-O-palmitoyl-1-thioglycerol (ara-CDP-DL-PTBA), arginine deaminase, asulacrine, atamestane, atrimustine, axinastatin 1, axinastatin 2, axinastatin 3, azasetron, azatoxin, azatyrosine, baccatin III derivatives, balanol, batimastat, breakpoint cluster region/abelson murine leukemia viral oncogene homolog 1 (BCR/ABL) antagonists, benzochlorins, benzoylstaurosporine, beta lactam derivatives, beta-alethine, betaclamycin B, betulinic acid, basic fibroblast growth factor (bFGF) inhibitor, bicalutamide, bisaziridinylspermine, bisnafide, bistratene A, bizelesin, breflate, bropirimine, budotitane, buthionine sulfoximine, calcipotriol, calphostin C, camptothecin derivatives, canarypox IL-2, capecitabine, carboxamide-amino-triazole, carboxyamidotriazole, CaRest M3.TM., CARN 700, carzelesin, castanospermine, cecropin B, cetrorelix, chlorins, chloroquinoxaline sulfonamide, cicaprost, cis-porphyrin, cladribine, clomifene analogues, clotrimazole, collismycin A, collismycin B, combretastatin A4, combretastatin analogue, conagenin, crambescidin 816, crisnatol, cryptophycin 8, curacin A, cyclopentanthraquinones, cycloplatam, cypemycin, cytarabine ocfosfate, cytolytic factor, cytostatin, dacliximab, decitabine, dehydrodidemnin B, deslorelin, dexifosfamide, dexrazoxane, dexverapamil, diaziquone, didemnin B, didox, diethylnorspermine, dihydro-5-azacytidine, dihydrotaxol, 9-dihydrotaxol, dioxamycin, diphenyl spiromustine, discodermolide, docosanol, dolasetron, doxifluridine, droloxifene, dronabinol, duocarmycin SA, ebselen, ecomustine, edelfosine, edrecolomab, eflornithine, elemene, emitefur, epothilones, desoxyepothilones (A and B), epithilones, epristeride, estramustine analogue, estrogen agonists, estrogen antagonists, androgen antagonists, etanidazole, etoposide, etoposide 4'-phosphate, exemestane, fadrozole, fazarabine, fenretinide, filgrastim, finasteride, flavopiridol, flezelastine, fluasterone, fludarabine, fluorodaunorunicin hydrochloride, forfenimex, formestane, fostriecin, fotemustine, gadolinium texaphyrin, gallium nitrate, galocitabine, gelatinase inhibitors, glutathione inhibitors, hepsulfam, heregulin, hexamethylene bisacetamide, hypericin, ibandronic acid, idarubicin, idoxifene, idramantone, ilmofosine, ilomastat, imidazoacridones, imiquimod, immunostimulant peptides, insulin-like growth factor-1 receptor inhibitor, interferon agonists, iobenguane, iododoxorubicin, 4-ipomeanol, irinotecan, iroplact, irsogladine, isobengazole, isohomohalicondrin B, itasetron, jasplakinolide, kahalalide F, lamellarin-N triacetate, lanreotide, leinamycin, lenograstim, lentinan sulfate, leptolstatin, letrozole, leukocyte alpha interferon, leuprolide+estrogen+progesterone, leuprorelin, levamisole, liarozole, lipophilic platinum compounds, lissoclinamide 7, lobaplatin, lombricine, lometrexol, lonidamine, losoxantrone, lovastatin, loxoribine, lurtotecan, lutetium texaphyrin, lysofylline, maitansine, mannostatin A, marimastat, masoprocol, matrilysin inhibitors, matrix metalloproteinase inhibitors, menogaril, merbarone, 2-Me-D-Trp(6),desgly(10)-lhrh ethylamide (Meterelin.TM.), methioninase, metoclopramide, macrophage migration inhibitory factor (MIF) inhibitor, mifepristone, miltefosine, mirimostim, plicamycin (Mithracin.TM.), mitoguazone, mitolactol, mitomycin analogues, mitonafide, mitotoxin fibroblast growth factor-saporin, mitoxantrone, mofarotene, molgramostim, monophosphoryl lipid A+myobacterium cell wall SK, mopidamol, mustard anticarcinoma agents, mycaperoxide B, myriaporone, N-acetyldinaline, N-substituted benzamides, nafarelin, nagrestip, naloxone+pentazocine, napavin, naphterpin, nartograstim, nedaplatin, neridronic acid, nilutamide, nisamycin, nitric oxide modulators, nitroxide antioxidant, nitrullyn, O6-benzylguanine, octreotide, okicenone, onapristone, ondansetron, oracin, ormaplatin, osaterone, oxaliplatin, oxaunomycin, paclitaxel analogues, paclitaxel derivatives, palauamine, palmitoylrhizoxin, pamidronic acid, panaxytriol, panomifene, parabactin, pazelliptine, pegaspargase, peldesine, pentosan polysulfate sodium, pentostatin, pentrozole, perflubron, perfosfamide, perillyl alcohol, phenazinomycin, phenylacetate, picibanil, pilocarpine hydrochloride, piritrexim, placetin A, placetin B, plasminogen activator inhibitor, platinum-triamine complex, podophyllotoxin, porfimer sodium, porfiromycin, propyl bis-acridone, prostaglandin J2, protein A-based immune modulator, protein kinase C inhibitors, microalgal, protein tyrosine phosphatase inhibitors, purine nucleoside phosphorylase inhibitors, purpurins, pyrazoloacridine, pyridoxylated hemoglobin polyoxyethylene conjugate, raf antagonists, ramosetron, ras farnesyl protein transferase inhibitors, ras inhibitors, ras-GAP inhibitor, retelliptine demethylated, rhenium (Re) 186 etidronate, rhizoxin, RII retinamide, rogletimide, rohitukine, romurtide, roquinimex, rubiginone B1, ruboxyl, safingol, saintopin, 2-chloroethyl-3-sarcosinamide-1-nitrosourea (SarCNU), sarcophytol A, sargramostim, Sdi 1 mimetics, semustine, senescence derived inhibitor 1, sizofiran, sobuzoxane, sodium borocaptate, sodium phenylacetate, solverol, sonermin, sparfosic acid, spicamycin D, splenopentin, spongistatin 1, squalamine, stipiamide, stromelysin inhibitors, sulfinosine, superactive vasoactive intestinal peptide antagonist, suradista, suramin, swainsonine, synthetic glycosaminoglycans, tallimustine, tamoxifen methiodide, tauromustine, tazarotene, tecogalan sodium, tegafur, tellurapyrylium, telomerase inhibitors, temoporfin, temozolomide, teniposide, tetrachlorodecaoxide, tetrazomine, thaliblastine, thalidomide, thiocoraline, thrombopoietin, thrombopoietin mimetic, thymalfasin, thymopoietin receptor agonist, thymotrinan, thyroid stimulating hormone, tin ethyl etiopurpurin, tirapazamine, titanocene dichloride, topotecan, topsentin, toremifene, totipotent stem cell factor, tretinoin, triacetyluridine, triciribine, triptorelin, tropisetron, turosteride, tyrphostins, ubiquitin C (UBC) inhibitors, ubenimex, urogenital sinus-derived growth inhibitory factor, urokinase receptor antagonists, vapreotide, variolin B, velaresol, veramine, verdins, verteporfin, vinorelbine, vinxaltine, vitaxin, vorozole, and combinations thereof.

26. The method according to claim 24, wherein said one or more chemotherapeutic agents are selected from the group consisting of: analogs of gonadotropin releasing hormone; nitrosoureas, 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloroethyl)-3-nitrosourea (ACNU), 1,3-bis (2-chloroethyl)-1-nitroso-urea (BCNU), 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU), N-hydroxyethylnitroso-N'-chloroethylurea (HCNU); cytostatic antibiotics, doxorubicin, pegylated liposomal doxorubicin, 5-fluorodeoxyuridine, 5-fluoro-2'-deoxyuridine 5'-monophosphate (5-FdUMP), 5-fluorouracil, 5-fluorouridine, procarbazine, docetaxel, gemcitabine, gemcitabine hydrochloride, telozolomide; vinca alkaloids, vinblastine, vincristine, vindesine; and acivicin, acodazole hydrochloride, acronine, ambomycin, ametantrone acetate, aminoglutethimide, anthramycin, asparaginase, asperlin, bevacizumab (Avastin.TM.), azacitidine, azetepa, azotomycin, benzodepa, bisantrene hydrochloride, bisnafide dimesylate, bleomycin sulfate, brequinar sodium, busulfan, cactinomycin, calusterone, caracemide, carbetimer, carboplatin, carmustine, carubicin hydrochloride, cedefingol, cetuximab, chlorambucil, cirolemycin, cisplatin, crisnatol mesylate, cyclophosphamide, cytarabine, dacarbazine, N-[2-(dimethyl-amino)ethyl]acridine-4-carboxamide (DACA), dactinomycin, daunomycin, dexormaplatin, dezaguanine, dezaguanine mesylate, droloxifene citrate, dromostanolone propionate, duazomycin, edatrexate, eflornithine hydrochloride, elsamitrucin, enloplatin, enpromate, epipropidine, epirubicin hydrochloride, erbulozole, erlotinib, esorubicin hydrochloride, estramustine, estramustine phosphate sodium, ethiodized oil I.sup.131, etoposide phosphate, etoprine, fadrozole hydrochloride, fludarabine phosphate, flurocitabine, fosquidone, fostriecin sodium, gefitinib (Iressa.TM.), gold (Au) 198, hydroxyurea, idarubicin hydrochloride, ifosfamide, imatinib mesylate, interferon alfa-2a, interferon alfa-2b, interferon alfa-n1, interferon alfa-n3, interferon beta-I a, interferon gamma-I b, iproplatin, irinotecan hydrochloride, lanreotide acetate, leuprolide acetate, liarozole hydrochloride, lometrexol sodium, lomustine, losoxantrone hydrochloride, maytansine, mechlorethamine hydrochloride, megestrol acetate, melengestrol acetate, melphalan, mercaptopurine, methotrexate, methotrexate sodium, metoprine, meturedepa, mitindomide, mitocarcin, mitocromin, mitogillin, mitomalcin, mitomycin, mitosper, mitotane, mitoxantrone hydrochloride, mycophenolic acid, nocodazole, nogalamycin, oxisuran, paclitaxel, peliomycin, pentamustine, peplomycin sulfate, pipobroman, piposulfan, piroxantrone hydrochloride, plicamycin, plomestane, prednimustine, procarbazine hydrochloride, puromycin, puromycin hydrochloride, pyrazofurin, riboprine, rituximab, safinol, safingol hydrochloride, simtrazene, sparfosate sodium, sparsomycin, spirogermanium hydrochloride, spiromustine, spiroplatin, streptonigrin, streptozocin, strontium (Sr) chloride 89, sulofenur, talisomycin, tamoxifen, taxane, taxoid, teloxantrone hydrochloride, teroxirone, testolactone, thiamiprine, thioguanine, thiotepa, nolatrexed (Thymitaq.TM.), tiazofurin, raltitrexed (Tomudex.TM.), 4beta-aminoalkyl-4'-O-demethyl-4-desoxypodophyllotoxin (TOP-53), topotecan hydrochloride: toremifene citrate, trastuzumab, trestolone acetate, triciribine phosphate, trimetrexate, trimetrexate glucuronate, tubulozole hydrochloride, uracil mustard, uredepa, vinblastine sulfate, vincristine sulfate, vindesine sulfate, vinepidine sulfate, vinglycinate sulfate, vinleurosine sulfate, vinorelbine tartrate, vinrosidine sulfate, vinzolidine sulfate, zeniplatin, zinostatin, zorubicin hydrochloride, 2-chlorodeoxyadenosine, 2'-deoxformycin, 9-aminocamptothecin, raltitrexed, N-propargyl-5,8-dideazafolic acid, 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine, 2-chloro-2'-deoxyadenosine, anisomycin, trichostatin A, hPRL-G129R, CEP-751, linomide, 20-epi-1,25 dihydroxyvitamin D3, 5-ethynyluracil, abiraterone, aclarubicin, acylfulvene, adecypenol, adozelesin, aldesleukin, ALL-tyrosine kinase (TK) antagonists, altretamine, ambamustine, amidox, amifostine, aminolevulinic acid, amrubicin, amsacrine, anagrelide, anastrozole, andrographolide, antagonist D, antagonist G, teverelix (Antarelix.TM.), anti-dorsalizing morphogenetic protein-1, antineoplaston, aphidicolin glycinate, apoptosis gene modulators, apoptosis regulators, apurinic acid, 1-beta-D-Arabinofuranosylcytosine 5'-diphosphate-rac-1-S-octadecyl-2-O-palmitoyl-1-thioglycerol (ara-CDP-DL-PTBA), arginine deaminase, asulacrine, atamestane, atrimustine, axinastatin 1, axinastatin 2, axinastatin 3, azasetron, azatoxin, azatyrosine, baccatin III derivatives, balanol, batimastat, breakpoint cluster region/abelson murine leukemia viral oncogene homolog 1 (BCR/ABL) antagonists, benzochlorins, benzoyl staurosporine, beta lactam derivatives, beta-alethine, betaclamycin B, betulinic acid, basic fibroblast growth factor (bFGF) inhibitor, bicalutamide, bisaziridinylspermine, bisnafide, bistratene A, bizelesin, breflate, bropirimine, budotitane, buthionine sulfoximine, calcipotriol, calphostin C, camptothecin derivatives, canarypox IL-2, capecitabine, carboxamide-amino-triazole, carboxyamidotriazole, CaRest M3.TM., CARN 700, cartilage derived inhibitor, carzelesin, casein kinase inhibitors (ICOS), castanospermine, cecropin B, cetrorelix, chlorins, chloroquinoxaline sulfonamide, cicaprost, cis-porphyrin, cladribine, clomifene analogues, clotrimazole, collismycin A, collismycin B, combretastatin A4, combretastatin analogue, conagenin, crambescidin 816, crisnatol, cryptophycin 8, cryptophycin A derivatives, curacin A, cyclopentanthraquinones, cycloplatam, cypemycin, cytarabine ocfosfate, cytolytic factor, cytostatin, dacliximab, decitabine, dehydrodidemnin B, deslorelin, dexifosfamide, dexrazoxane, dexverapamil, diaziquone, didemnin B, didox, diethylnorspermine, dihydro-5-azacytidine, dihydrotaxol, 9-dihydrotaxol, dioxamycin, diphenyl spiromustine, discodermolide, docosanol, dolasetron, doxifluridine, droloxifene, dronabinol, duocarmycin SA, ebselen, ecomustine, edelfosine, edrecolomab, eflornithine, elemene, emitefur, epirubicin, epothilones, desoxyepothilones (A and B), epithilones, epristeride, estramustine analogue, estrogen agonists, estrogen antagonists, androgen antagonists, etanidazole, etoposide, etoposide 4'-phosphate, exemestane, fadrozole, fazarabine, fenretinide, filgrastim, finasteride, flavopiridol, flezelastine, fluasterone, fludarabine, fluorodaunorunicin hydrochloride, forfenimex, formestane, fostriecin, fotemustine, gadolinium texaphyrin, gallium nitrate, galocitabine, gelatinase inhibitors, glutathione inhibitors, hepsulfam, heregulin, hexamethylene bisacetamide, hypericin, ibandronic acid, idarubicin, idoxifene, idramantone, ilmofosine, ilomastat, imidazoacridones, imiquimod, immunostimulant peptides, insulin-like growth factor-1 receptor inhibitor, interferon agonists, interferons, interleukins, iobenguane, iododoxorubicin, 4-ipomeanol, irinotecan, iroplact, irsogladine, isobengazole, isohomohalicondrin B, itasetron, jasplakinolide, kahalalide F, lamellarin-N triacetate, lanreotide, leinamycin, lenograstim, lentinan sulfate, leptolstatin, letrozole, leukemia inhibiting factor, leukocyte alpha interferon, leuprolide+estrogen+progesterone, leuprorelin, levamisole, liarozole, lipophilic platinum compounds, lissoclinamide 7, lobaplatin, lombricine, lometrexol, lonidamine, losoxantrone, lovastatin, loxoribine, lurtotecan, lutetium texaphyrin, lysofylline, maitansine, mannostatin A, marimastat, masoprocol, matrilysin inhibitors, matrix metalloproteinase inhibitors, menogaril, merbarone, 2-Me-D-Trp(6),desgly(10)-lhrh ethylamide (Meterelin.TM.), methioninase, metoclopramide, macrophage migration inhibitory factor (MIF) inhibitor, mifepristone, miltefosine, mirimostim, plicamycin (Mithracin.TM.), mitoguazone, mitolactol, mitomycin analogues, mitonafide, mitotoxin fibroblast growth factor-saporin, mitoxantrone, mofarotene, molgramostim, monoclonal antibody, human chorionic gonadotrophin, monophosphoryl lipid A+myobacterium cell wall SK, mopidamol, multiple drug resistance gene inhibitor, mustard anticarcinoma agents, mycaperoxide B, mycobacterial cell wall extract, myriaporone, N-acetyldinaline, N-substituted benzamides, nafarelin, nagrestip, naloxone+pentazocine, napavin, naphterpin, nartograstim, nedaplatin, nemorubicin, neridronic acid, neutral endopeptidase, nilutamide, nisamycin, nitric oxide modulators, nitroxide antioxidant, nitrullyn, O6-benzylguanine, octreotide, okicenone, onapristone, ondansetron, oracin, ormaplatin, osaterone, oxaliplatin, oxaunomycin, paclitaxel analogues, paclitaxel derivatives, palauamine, palmitoylrhizoxin, pamidronic acid, panaxytriol, panomifene, parabactin, pazelliptine, pegaspargase, peldesine, pentosan polysulfate sodium, pentostatin, pentrozole, perflubron, perfosfamide, perillyl alcohol, phenazinomycin, phenyl acetate, phosphatase inhibitors, picibanil, pilocarpine hydrochloride, pirarubicin, piritrexim, placetin A, placetin B, plasminogen activator inhibitor, platinum-triamine complex, podophyllotoxin, porfimer sodium, porfiromycin, propyl bis-acridone, prostaglandin J2, proteasome inhibitors, protein A-based immune modulator, protein kinase C inhibitors, microalgal, protein tyrosine phosphatase inhibitors, purine nucleoside phosphorylase inhibitors, purpurins, pyrazoloacridine, pyridoxylated hemoglobin polyoxyethylene conjugate, raf antagonists, ramosetron, ras farnesyl protein transferase inhibitors, ras inhibitors, ras-GAP inhibitor, retelliptine demethylated, rhenium (Re) 186 etidronate, rhizoxin, ribozymes, RH retinamide, rogletimide, rohitukine, romurtide, roquinimex, rubiginone B1, ruboxyl, safingol, saintopin, 2-chloroethyl-3-sarcosinamide-1-nitrosourea (SarCNU), sarcophytol A, sargramostim, Sdi 1 mimetics, semustine, senescence derived inhibitor 1, single chain antigen binding protein, sizofiran, sobuzoxane, sodium borocaptate, sodium phenylacetate, solverol, somatomedin binding protein, sonermin, sparfosic acid, spicamycin D, splenopentin, spongistatin 1, squalamine, stipiamide, stromelysin inhibitors, sulfinosine, superactive vasoactive intestinal peptide antagonist, suradista, suramin, swainsonine, synthetic glycosaminoglycans, tallimustine, tamoxifen methiodide, tauromustine, tazarotene, tecogalan sodium, tegafur, tellurapyrylium, telomerase inhibitors, temoporfin, temozolomide, teniposide, tetrachlorodecaoxide, tetrazomine, thaliblastine, thalidomide, thiocoraline, thrombopoietin, thrombopoietin mimetic, thymalfasin, thymopoietin receptor agonist, thymotrinan, thyroid stimulating hormone, tin ethyl etiopurpurin, tirapazamine, titanocene dichloride, topotecan, topsentin, toremifene, totipotent stem cell factor, tretinoin, triacetyluridine, triciribine, triptorelin, tropisetron, turosteride, tyrosine kinase inhibitors, tyrphostins, ubiquitin C (UBC) inhibitors, ubenimex, urogenital sinus-derived growth inhibitory factor, urokinase receptor antagonists, vapreotide, variolin B, velaresol, veramine, verdins, verteporfin, vinorelbine, vinxaltine, vitaxin, vorozole, and combinations thereof.

27. A method for treating a proliferative disorder comprising administering to a subject in need thereof a formulation comprising occidiofungin, and one or more cyclodextrins and an aqueous solvent in an amount effective to treat the proliferative disorder, wherein said formulation comprises either a) said occidiofungin in an amount ranging from about 20 g/mL to about 1 g/mL; or b) said one or more cyclodextrins at between about 0.5% to about 10% weight/volume (w/v) of said formulation, wherein said proliferative disorder is ovarian cancer or lymphoma.

28. The method according to claim 27, wherein said formulation comprises between about 0.5% to about 10% weight/volume (w/v) of said one or more cyclodextrins.

29. The method according to claim 27, wherein said formulation comprises said occidiofungin in an amount ranging from about 20 .mu.g/mL to about 1 g/mL.

30. The method according to claim 27, wherein said one or more cyclodextrins is selected from the group consisting of .alpha.-cyclodextrin, .beta.-cyclodextrin, .gamma.-cyclodextrin, cyclomaltonose, variants thereof, and any combination thereof.

31. The method according to claim 30, wherein said one or more cyclodextrins is selected from the group consisting of hydroxypropyl-.beta.-cyclodextrin, sulfobutylether-.beta.-cyclodextrin, hydroxyethyl .beta.-cyclodextrin, methyl-.beta.-cyclodextrin, dimethyl-.beta.-cyclodextrin, randomly dimethylated-.beta.-cyclodextrin, randomly methylated-.beta.-cyclodextrin, carboxymethyl-.beta.-cyclodextrin, carboxymethyl ethyl-.beta.-cyclodextrin, diethyl-.beta.-cyclodextrin, tri-O-methyl-.beta.-cyclodextrin, tri-O-ethyl-.beta.-cyclodextrin, tri-O-butyryl-.beta.-cyclodextrin, tri-O-valeryl-.gamma.-cyclodextrin, di-O-hexanoyl-.beta.-cyclodextrin, glucosyl-.beta.-cyclodextrin, maltosyl-.beta.-cyclodextrin, and 2-hydroxy-3-trimethyl-ammoniopropyl-.beta.-cyclodextrin, or combinations thereof.

32. The method according to claim 27, wherein said one or more cyclodextrins is hydroxypropyl-.beta.-cyclodextrin.

33. The method according to claim 27, wherein said formulation further comprises lipid vesicles.

34. The method according to claim 33, wherein said lipid vesicles comprise lipids selected from the group consisting of 1,2-Dioleoyl-sn-glycero-3-phosphocholine, 1,2-dipalmitoyl-sn-glycero-3-[phospho-rac-(3-lysyl(1-glycerol))], and combinations thereof.

35. The method according to claim 27, wherein said aqueous solvent is a pharmaceutically acceptable buffer, excipient, or combination thereof.

36. The method according to claim 35, wherein said pharmaceutically acceptable buffer, excipient, or combination thereof is selected from the group consisting of Ringer's solution, isotonic saline, isotonic glucose solutions, distilled water, and phosphate buffered saline.

37. The method according to claim 27, further comprising administering to the subject in need thereof at least one chemotherapeutic agent in an amount effective to treat said ovarian cancer or lymphoma.

38. The method according to claim 37, wherein said at least one chemotherapeutic agent is selected from the group consisting of: analogs of gonadotropin releasing hormone; nitrosoureas, 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloroethyl)-3-nitrosourea (ACNU), 1,3-bis (2-chloroethyl)-1-nitroso-urea (BCNU), 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU), N-hydroxyethylnitroso-N'-chloroethylurea (HCNU); cytostatic antibiotics, doxorubicin, pegylated liposomal doxorubicin, 5-fluorodeoxyuridine, 5-fluoro-2'-deoxyuridine 5'-monophosphate (5-FdUMP), 5-fluorouracil, 5-fluorouridine, procarbazine, docetaxel, gemcitabine, gemcitabine hydrochloride, telozolomide, epirubicin, epirubicin hydrochloride, idarubicin hydrochloride, zorubicin hydrochloride, aclarubicin, amrubicin, nemorubicin, pirarubicin; vinca alkaloids, vinblastine, vincristine, vindesine; and acivicin, acodazole hydrochloride, acronine, ambomycin, ametantrone acetate, aminoglutethimide, anthramycin, asparaginase, asperlin, bevacizumab (Avastin.TM.), azacitidine, azetepa, azotomycin, benzodepa, bisantrene hydrochloride, bisnafide dimesylate, bleomycin sulfate, brequinar sodium, busulfan, cactinomycin, calusterone, caracemide, carbetimer, carboplatin, carmustine, carubicin hydrochloride, cedefingol, cetuximab, chlorambucil, cirolemycin, cisplatin, crisnatol mesylate, cyclophosphamide, cytarabine, dacarbazine, N-[2-(dimethyl-amino)ethyl]acridine-4-carboxamide (DACA), dactinomycin, daunomycin, dexormaplatin, dezaguanine, dezaguanine mesylate, droloxifene citrate, dromostanolone propionate, duazomycin, edatrexate, eflornithine hydrochloride, elsamitrucin, enloplatin, enpromate, epipropidine, erbulozole, erlotinib, esorubicin hydrochloride, estramustine, estramustine phosphate sodium, ethiodized oil I.sup.131, etoposide phosphate, etoprine, fadrozole hydrochloride, fludarabine phosphate, flurocitabine, fosquidone, fostriecin sodium, gefitinib (Iressa.TM.), gold (Au) 198, hydroxyurea, ifosfamide, imatinib mesylate, interferon alfa-2a, interferon alfa-2b, interferon alfa-n1, interferon alfa-n3, interferon beta-I a, interferon gamma-I b, iproplatin, irinotecan hydrochloride, lanreotide acetate, leuprolide acetate, liarozole hydrochloride, lometrexol sodium, lomustine, losoxantrone hydrochloride, maytansine, mechlorethamine hydrochloride, megestrol acetate, melengestrol acetate, melphalan, mercaptopurine, methotrexate, methotrexate sodium, metoprine, meturedepa, mitindomide, mitocarcin, mitocromin, mitogillin, mitomalcin, mitomycin, mitosper, mitotane, mitoxantrone hydrochloride, mycophenolic acid, nocodazole, nogalamycin, oxisuran, paclitaxel, peliomycin, pentamustine, peplomycin sulfate, pipobroman, piposulfan, piroxantrone hydrochloride, plicamycin, plomestane, prednimustine, procarbazine hydrochloride, puromycin, puromycin hydrochloride, pyrazofurin, riboprine, rituximab, safinol, safingol hydrochloride, simtrazene, sparfosate sodium, sparsomycin, spirogermanium hydrochloride, spiromustine, spiroplatin, streptonigrin, streptozocin, strontium 89 (Sr) chloride, sulofenur, talisomycin, tamoxifen, taxane, taxoid, teloxantrone hydrochloride, teroxirone, testolactone, thiamiprine, thioguanine, thiotepa, nolatrexed (Thymitaq.TM.), tiazofurin, raltitrexed (Tomudex.TM.), 4beta-aminoalkyl-4'-O-demethyl-4-desoxypodophyllotoxin (TOP-53), topotecan hydrochloride: toremifene citrate, trastuzumab, trestolone acetate, triciribine phosphate, trimetrexate, trimetrexate glucuronate, tubulozole hydrochloride, uracil mustard, uredepa, vinblastine sulfate, vincristine sulfate, vindesine sulfate, vinepidine sulfate, vinglycinate sulfate, vinleurosine sulfate, vinorelbine tartrate, vinrosidine sulfate, vinzolidine sulfate, zeniplatin, zinostatin, 2-chlorodeoxyadenosine, 2'-deoxformycin, 9-aminocamptothecin, raltitrexed, N-propargyl-5,8-dideazafolic acid, 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine, 2-chloro-2'-deoxyadenosine, anisomycin, trichostatin A, hPRL-G129R, CEP-751, linomide, 20-epi-1,25 dihydroxyvitamin D3, 5-ethynyluracil, abiraterone, acylfulvene, adecypenol, adozelesin, aldesleukin, ALL-tyrosine kinase (TK) antagonists, altretamine, ambamustine, amidox, amifostine, aminolevulinic acid, amsacrine, anagrelide, anastrozole, andrographolide, antagonist D, antagonist G, teverelix (Antarelix.TM.), anti-dorsalizing morphogenetic protein-1, antineoplaston, aphidicolin glycinate, apoptosis gene modulators, apoptosis regulators, apurinic acid, 1-beta-D-Arabinofuranosylcytosine 5'-diphosphate-rac-1-S-octadecyl-2-O-palmitoyl-1-thioglycerol (ara-CDP-DL-PTBA), arginine deaminase, asulacrine, atamestane, atrimustine, axinastatin 1, axinastatin 2, axinastatin 3, azasetron, azatoxin, azatyrosine, baccatin III derivatives, balanol, batimastat, breakpoint cluster region/abelson murine leukemia viral oncogene homolog 1 (BCR/ABL) antagonists, benzochlorins, benzoylstaurosporine, beta lactam derivatives, beta-alethine, betaclamycin B, betulinic acid, basic fibroblast growth factor (bFGF) inhibitor, bicalutamide, bisaziridinylspermine, bisnafide, bistratene A, bizelesin, breflate, bropirimine, budotitane, buthionine sulfoximine, calcipotriol, calphostin C, camptothecin derivatives, canarypox IL-2, capecitabine, carboxamide-amino-triazole, carboxyamidotriazole, CaRest M3.TM., CARN 700, carzelesin, castanospermine, cecropin B, cetrorelix, chlorins, chloroquinoxaline sulfonamide, cicaprost, cis-porphyrin, cladribine, clomifene analogues, clotrimazole, collismycin A, collismycin B, combretastatin A4, combretastatin analogue, conagenin, crambescidin 816, crisnatol, cryptophycin 8, curacin A, cyclopentanthraquinones, cycloplatam, cypemycin, cytarabine ocfosfate, cytolytic factor, cytostatin, dacliximab, decitabine, dehydrodidemnin B, deslorelin, dexifosfamide, dexrazoxane, dexverapamil, diaziquone, didemnin B, didox, diethylnorspermine, dihydro-5-azacytidine, dihydrotaxol, 9-dihydrotaxol, dioxamycin, diphenyl spiromustine, discodermolide, docosanol, dolasetron, doxifluridine, droloxifene, dronabinol, duocarmycin SA, ebselen, ecomustine, edelfosine, edrecolomab, eflornithine, elemene, emitefur, epothilones, desoxyepothilones (A and B), epithilones, epristeride, estramustine analogue, estrogen agonists, estrogen antagonists, androgen antagonists, etanidazole, etoposide, etoposide 4'-phosphate, exemestane, fadrozole, fazarabine, fenretinide, filgrastim, finasteride, flavopiridol, flezelastine, fluasterone, fludarabine, fluorodaunorunicin hydrochloride, forfenimex, formestane, fostriecin, fotemustine, gadolinium texaphyrin, gallium nitrate, galocitabine, gelatinase inhibitors, glutathione inhibitors, hepsulfam, heregulin, hexamethylene bisacetamide, hypericin, ibandronic acid, idarubicin, idoxifene, idramantone, ilmofosine, ilomastat, imidazoacridones, imiquimod, immunostimulant peptides, insulin-like growth factor-1 receptor inhibitor, interferon agonists, iobenguane, iododoxorubicin, 4-ipomeanol, irinotecan, iroplact, irsogladine, isobengazole, isohomohalicondrin B, itasetron, jasplakinolide, kahalalide F, lamellarin-N triacetate, lanreotide, leinamycin, lenograstim, lentinan sulfate, leptolstatin, letrozole, leukocyte alpha interferon, leuprolide+estrogen+progesterone, leuprorelin, levamisole, liarozole, lipophilic platinum compounds, lissoclinamide 7, lobaplatin, lombricine, lometrexol, lonidamine, losoxantrone, lovastatin, loxoribine, lurtotecan, lutetium texaphyrin, lysofylline, maitansine, mannostatin A, marimastat, masoprocol, matrilysin inhibitors, matrix metalloproteinase inhibitors, menogaril, merbarone, 2-Me-D-Trp(6),desgly(10)-lhrh ethylamide (Meterelin.TM.), methioninase, metoclopramide, macrophage migration inhibitory factor (MIF) inhibitor, mifepristone, miltefosine, mirimostim, plicamycin (Mithracin.TM.), mitoguazone, mitolactol, mitomycin analogues, mitonafide, mitotoxin fibroblast growth factor-saporin, mitoxantrone, mofarotene, molgramostim, monophosphoryl lipid A+myobacterium cell wall SK, mopidamol, mustard anticarcinoma agents, mycaperoxide B, myriaporone, N-acetyldinaline, N-substituted benzamides, nafarelin, nagrestip, naloxone+pentazocine, napavin, naphterpin, nartograstim, nedaplatin, neridronic acid, nilutamide, nisamycin, nitric oxide modulators, nitroxide antioxidant, nitrullyn, O6-benzylguanine, octreotide, okicenone, onapristone, ondansetron, oracin, ormaplatin, osaterone, oxaliplatin, oxaunomycin, paclitaxel analogues, paclitaxel derivatives, palauamine, palmitoylrhizoxin, pamidronic acid, panaxytriol, panomifene, parabactin, pazelliptine, pegaspargase, peldesine, pentosan polysulfate sodium, pentostatin, pentrozole, perflubron, perfosfamide, perillyl alcohol, phenazinomycin, phenylacetate, picibanil, pilocarpine hydrochloride, piritrexim, placetin A, placetin B, plasminogen activator inhibitor, platinum-triamine complex, podophyllotoxin, porfimer sodium, porfiromycin, propyl bis-acridone, prostaglandin J2, protein A-based immune modulator, protein kinase C inhibitors, microalgal, protein tyrosine phosphatase inhibitors, purine nucleoside phosphorylase inhibitors, purpurins, pyrazoloacridine, pyridoxylated hemoglobin polyoxyethylene conjugate, raf antagonists, ramosetron, ras farnesyl protein transferase inhibitors, ras inhibitors, ras-GAP inhibitor, retelliptine demethylated, rhenium (Re) 186 etidronate, rhizoxin, RII retinamide, rogletimide, rohitukine, romurtide, roquinimex, rubiginone B1, ruboxyl, safingol, saintopin, 2-chloroethyl-3-sarcosinamide-1-nitrosourea (SarCNU), sarcophytol A, sargramostim, Sdi 1 mimetics, semustine, senescence derived inhibitor 1, sizofiran, sobuzoxane, sodium borocaptate, sodium phenylacetate, solverol, sonermin, sparfosic acid, spicamycin D, splenopentin, spongistatin 1, squalamine, stipiamide, stromelysin inhibitors, sulfinosine, superactive vasoactive intestinal peptide antagonist, suradista, suramin, swainsonine, synthetic glycosaminoglycans, tallimustine, tamoxifen methiodide, tauromustine, tazarotene, tecogalan sodium, tegafur, tellurapyrylium, telomerase inhibitors, temoporfin, temozolomide, teniposide, tetrachlorodecaoxide, tetrazomine, thaliblastine, thalidomide, thiocoraline, thrombopoietin, thrombopoietin mimetic, thymalfasin, thymopoietin receptor agonist, thymotrinan, thyroid stimulating hormone, tin ethyl etiopurpurin, tirapazamine, titanocene dichloride, topotecan, topsentin, toremifene, totipotent stem cell factor, tretinoin, triacetyluridine, triciribine, triptorelin, tropisetron, turosteride, tyrphostins, ubiquitin C (UBC) inhibitors, ubenimex, urogenital sinus-derived growth inhibitory factor, urokinase receptor antagonists, vapreotide, variolin B, velaresol, veramine, verdins, verteporfin, vinorelbine, vinxaltine, vitaxin, vorozole, and combinations thereof.

39. The method according to claim 37, wherein said method comprises the sequential administration of said formulation and said at least one chemotherapeutic agent.

40. The method according to claim 27, wherein the subject in need thereof is a mammal.

41. The method according to claim 40, wherein said mammal is a non-human animal.

42. The method according to claim 41, wherein said non-human animal is a rodent, chimpanzee, monkey, or dog.

43. The method according to claim 40, wherein said mammal is a human.

44. The method according to claim 37, wherein said at least one chemotherapeutic agent is selected from the group consisting of: analogs of gonadotropin releasing hormone; nitrosoureas, 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloroethyl)-3-nitrosourea (ACNU), 1,3-bis (2-chloroethyl)-1-nitroso-urea (BCNU), 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU), N-hydroxyethylnitroso-N'-chloroethylurea (HCNU); cytostatic antibiotics, doxorubicin, pegylated liposomal doxorubicin, 5-fluorodeoxyuridine, 5-fluoro-2'-deoxyuridine 5'-monophosphate (5-FdUMP), 5-fluorouracil, 5-fluorouridine, procarbazine, docetaxel, gemcitabine, gemcitabine hydrochloride, telozolomide; vinca alkaloids, vinblastine, vincristine, vindesine; and acivicin, acodazole hydrochloride, acronine, ambomycin, ametantrone acetate, aminoglutethimide, anthramycin, asparaginase, asperlin, bevacizumab (Avastin.TM.), azacitidine, azetepa, azotomycin, benzodepa, bisantrene hydrochloride, bisnafide dimesylate, bleomycin sulfate, brequinar sodium, busulfan, cactinomycin, calusterone, caracemide, carbetimer, carboplatin, carmustine, carubicin hydrochloride, cedefingol, cetuximab, chlorambucil, cirolemycin, cisplatin, crisnatol mesylate, cyclophosphamide, cytarabine, dacarbazine, N-[2-(dimethyl-amino)ethyl]acridine-4-carboxamide (DACA), dactinomycin, daunomycin, dexormaplatin, dezaguanine, dezaguanine mesylate, droloxifene citrate, dromostanolone propionate, duazomycin, edatrexate, eflornithine hydrochloride, elsamitrucin, enloplatin, enpromate, epipropidine, epirubicin hydrochloride, erbulozole, erlotinib, esorubicin hydrochloride, estramustine, estramustine phosphate sodium, ethiodized oil I.sup.131, etoposide phosphate, etoprine, fadrozole hydrochloride, fludarabine phosphate, flurocitabine, fosquidone, fostriecin sodium, gefitinib (Iressa.TM.), gold (Au) 198, hydroxyurea, idarubicin hydrochloride, ifosfamide, imatinib mesylate, interferon alfa-2a, interferon alfa-2b, interferon alfa-n1, interferon alfa-n3, interferon beta-I a, interferon gamma-I b, iproplatin, irinotecan hydrochloride, lanreotide acetate, leuprolide acetate, liarozole hydrochloride, lometrexol sodium, lomustine, losoxantrone hydrochloride, maytansine, mechlorethamine hydrochloride, megestrol acetate, melengestrol acetate, melphalan, mercaptopurine, methotrexate, methotrexate sodium, metoprine, meturedepa, mitindomide, mitocarcin, mitocromin, mitogillin, mitomalcin, mitomycin, mitosper, mitotane, mitoxantrone hydrochloride, mycophenolic acid, nocodazole, nogalamycin, oxisuran, paclitaxel, peliomycin, pentamustine, peplomycin sulfate, pipobroman, piposulfan, piroxantrone hydrochloride, plicamycin, plomestane, prednimustine, procarbazine hydrochloride, puromycin, puromycin hydrochloride, pyrazofurin, riboprine, rituximab, safinol, safingol hydrochloride, simtrazene, sparfosate sodium, sparsomycin, spirogermanium hydrochloride, spiromustine, spiroplatin, streptonigrin, streptozocin, strontium (Sr) chloride 89, sulofenur, talisomycin, tamoxifen, taxane, taxoid, teloxantrone hydrochloride, teroxirone, testolactone, thiamiprine, thioguanine, thiotepa, nolatrexed (Thymitaq.TM.), tiazofurin, raltitrexed (Tomudex.TM.), 4beta-aminoalkyl-4'-O-demethyl-4-desoxypodophyllotoxin (TOP-53), topotecan hydrochloride: toremifene citrate, trastuzumab, trestolone acetate, triciribine phosphate, trimetrexate, trimetrexate glucuronate, tubulozole hydrochloride, uracil mustard, uredepa, vinblastine sulfate, vincristine sulfate, vindesine sulfate, vinepidine sulfate, vinglycinate sulfate, vinleurosine sulfate, vinorelbine tartrate, vinrosidine sulfate, vinzolidine sulfate, zeniplatin, zinostatin, zorubicin hydrochloride, 2-chlorodeoxyadenosine, 2'-deoxformycin, 9-aminocamptothecin, raltitrexed, N-propargyl-5,8-dideazafolic acid, 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine, 2-chloro-2'-deoxyadenosine, anisomycin, trichostatin A, hPRL-G129R, CEP-751, linomide, 20-epi-1,25 dihydroxyvitamin D3, 5-ethynyluracil, abiraterone, aclarubicin, acylfulvene, adecypenol, adozelesin, aldesleukin, ALL-tyrosine kinase (TK) antagonists, altretamine, ambamustine, amidox, amifostine, aminolevulinic acid, amrubicin, amsacrine, anagrelide, anastrozole, andrographolide, antagonist D, antagonist G, teverelix (Antarelix.TM.), anti-dorsalizing morphogenetic protein-1, antineoplaston, aphidicolin glycinate, apoptosis gene modulators, apoptosis regulators, apurinic acid, 1-beta-D-Arabinofuranosylcytosine 5'-diphosphate-rac-1-S-octadecyl-2-O-palmitoyl-1-thioglycerol (ara-CDP-DL-PTBA), arginine deaminase, asulacrine, atamestane, atrimustine, axinastatin 1, axinastatin 2, axinastatin 3, azasetron, azatoxin, azatyrosine, baccatin III derivatives, balanol, batimastat, breakpoint cluster region/abelson murine leukemia viral oncogene homolog 1 (BCR/ABL) antagonists, benzochlorins, benzoyl staurosporine, beta lactam derivatives, beta-alethine, betaclamycin B, betulinic acid, basic fibroblast growth factor (bFGF) inhibitor, bicalutamide, bisaziridinylspermine, bisnafide, bistratene A, bizelesin, breflate, bropirimine, budotitane, buthionine sulfoximine, calcipotriol, calphostin C, camptothecin derivatives, canarypox IL-2, capecitabine, carboxamide-amino-triazole, carboxyamidotriazole, CaRest M3.TM., CARN 700, cartilage derived inhibitor, carzelesin, casein kinase inhibitors (ICOS), castanospermine, cecropin B, cetrorelix, chlorins, chloroquinoxaline sulfonamide, cicaprost, cis-porphyrin, cladribine, clomifene analogues, clotrimazole, collismycin A, collismycin B, combretastatin A4, combretastatin analogue, conagenin, crambescidin 816, crisnatol, cryptophycin 8, cryptophycin A derivatives, curacin A, cyclopentanthraquinones, cycloplatam, cypemycin, cytarabine ocfosfate, cytolytic factor, cytostatin, dacliximab, decitabine, dehydrodidemnin B, deslorelin, dexifosfamide, dexrazoxane, dexverapamil, diaziquone, didemnin B, didox, diethylnorspermine, dihydro-5-azacytidine, dihydrotaxol, 9-dihydrotaxol, dioxamycin, diphenyl spiromustine, discodermolide, docosanol, dolasetron, doxifluridine, droloxifene, dronabinol, duocarmycin SA, ebselen, ecomustine, edelfosine, edrecolomab, eflornithine, elemene, emitefur, epirubicin, epothilones, desoxyepothilones (A and B), epithilones, epristeride, estramustine analogue, estrogen agonists, estrogen antagonists, androgen antagonists, etanidazole, etoposide, etoposide 4'-phosphate, exemestane, fadrozole, fazarabine, fenretinide, filgrastim, finasteride, flavopiridol, flezelastine, fluasterone, fludarabine, fluorodaunorunicin hydrochloride, forfenimex, formestane, fostriecin, fotemustine, gadolinium texaphyrin, gallium nitrate, galocitabine, gelatinase inhibitors, glutathione inhibitors, hepsulfam, heregulin, hexamethylene bisacetamide, hypericin, ibandronic acid, idarubicin, idoxifene, idramantone, ilmofosine, ilomastat, imidazoacridones, imiquimod, immunostimulant peptides, insulin-like growth factor-1 receptor inhibitor, interferon agonists, interferons, interleukins, iobenguane, iododoxorubicin, 4-ipomeanol, irinotecan, iroplact, irsogladine, isobengazole, isohomohalicondrin B, itasetron, jasplakinolide, kahalalide F, lamellarin-N triacetate, lanreotide, leinamycin, lenograstim, lentinan sulfate, leptolstatin, letrozole, leukemia inhibiting factor, leukocyte alpha interferon, leuprolide+estrogen+progesterone, leuprorelin, levamisole, liarozole, lipophilic platinum compounds, lissoclinamide 7, lobaplatin, lombricine, lometrexol, lonidamine, losoxantrone, lovastatin, loxoribine, lurtotecan, lutetium texaphyrin, lysofylline, maitansine, mannostatin A, marimastat, masoprocol, matrilysin inhibitors, matrix metalloproteinase inhibitors, menogaril, merbarone, 2-Me-D-Trp(6),desgly(10)-lhrh ethylamide (Meterelin.TM.), methioninase, metoclopramide, macrophage migration inhibitory factor (MIF) inhibitor, mifepristone, miltefosine, mirimostim, plicamycin (Mithracin.TM.), mitoguazone, mitolactol, mitomycin analogues, mitonafide, mitotoxin fibroblast growth factor-saporin, mitoxantrone, mofarotene, molgramostim, monoclonal antibody, human chorionic gonadotrophin, monophosphoryl lipid A+myobacterium cell wall SK, mopidamol, multiple drug resistance gene inhibitor, mustard anticarcinoma agents, mycaperoxide B, mycobacterial cell wall extract, myriaporone, N-acetyldinaline, N-substituted benzamides, nafarelin, nagrestip, naloxone+pentazocine, napavin, naphterpin, nartograstim, nedaplatin, nemorubicin, neridronic acid, neutral endopeptidase, nilutamide, nisamycin, nitric oxide modulators, nitroxide antioxidant, nitrullyn, O6-benzylguanine, octreotide, okicenone, onapristone, ondansetron, oracin, ormaplatin, osaterone, oxaliplatin, oxaunomycin, paclitaxel analogues, paclitaxel derivatives, palauamine, palmitoylrhizoxin, pamidronic acid, panaxytriol, panomifene, parabactin, pazelliptine, pegaspargase, peldesine, pentosan polysulfate sodium, pentostatin, pentrozole, perflubron, perfosfamide, perillyl alcohol, phenazinomycin, phenyl acetate, phosphatase inhibitors, picibanil, pilocarpine hydrochloride, pirarubicin, piritrexim, placetin A, placetin B, plasminogen activator inhibitor, platinum-triamine complex, podophyllotoxin, porfimer sodium, porfiromycin, propyl bis-acridone, prostaglandin J2, proteasome inhibitors, protein A-based immune modulator, protein kinase C inhibitors, microalgal, protein tyrosine phosphatase inhibitors, purine nucleoside phosphorylase inhibitors, purpurins, pyrazoloacridine, pyridoxylated hemoglobin polyoxyethylene conjugate, raf antagonists, ramosetron, ras farnesyl protein transferase inhibitors, ras inhibitors, ras-GAP inhibitor, retelliptine demethylated, rhenium (Re) 186 etidronate, rhizoxin, ribozymes, RH retinamide, rogletimide, rohitukine, romurtide, roquinimex, rubiginone B1, ruboxyl, safingol, saintopin, 2-chloroethyl-3-sarcosinamide-1-nitrosourea (SarCNU), sarcophytol A, sargramostim, Sdi 1 mimetics, semustine, senescence derived inhibitor 1, single chain antigen binding protein, sizofiran, sobuzoxane, sodium borocaptate, sodium phenylacetate, solverol, somatomedin binding protein, sonermin, sparfosic acid, spicamycin D, splenopentin, spongistatin 1, squalamine, stipiamide, stromelysin inhibitors, sulfinosine, superactive vasoactive intestinal peptide antagonist, suradista, suramin, swainsonine, synthetic glycosaminoglycans, tallimustine, tamoxifen methiodide, tauromustine, tazarotene, tecogalan sodium, tegafur, tellurapyrylium, telomerase inhibitors, temoporfin, temozolomide, teniposide, tetrachlorodecaoxide, tetrazomine, thaliblastine, thalidomide, thiocoraline, thrombopoietin, thrombopoietin mimetic, thymalfasin, thymopoietin receptor agonist, thymotrinan, thyroid stimulating hormone, tin ethyl etiopurpurin, tirapazamine, titanocene dichloride, topotecan, topsentin, toremifene, totipotent stem cell factor, tretinoin, triacetyluridine, triciribine, triptorelin, tropisetron, turosteride, tyrosine kinase inhibitors, tyrphostins, ubiquitin C (UBC) inhibitors, ubenimex, urogenital sinus-derived growth inhibitory factor, urokinase receptor antagonists, vapreotide, variolin B, velaresol, veramine, verdins, verteporfin, vinorelbine, vinxaltine, vitaxin, vorozole, and combinations thereof.

Summary for Patent:   Start Trial

PCT Information
PCT FiledSeptember 14, 2015PCT Application Number:PCT/US2015/049972
PCT Publication Date:March 17, 2016PCT Publication Number:WO2016/040940

Details for Patent 10,265,374

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Microbix Biosystems KINLYTIC urokinase INJECTABLE;INJECTION 021846 001 1978-01-16   Start Trial MISSISSIPPI STATE UNIVERSITY (Starkville, MS) THE TEXAS A&M UNIVERSITY SYSTEM (College Station, TX) 2034-09-12 DISCN search
Microbix Biosystems KINLYTIC urokinase INJECTABLE;INJECTION 021846 002 1978-01-16   Start Trial MISSISSIPPI STATE UNIVERSITY (Starkville, MS) THE TEXAS A&M UNIVERSITY SYSTEM (College Station, TX) 2034-09-12 DISCN search
Microbix Biosystems KINLYTIC urokinase INJECTABLE;INJECTION 021846 003 1978-01-16   Start Trial MISSISSIPPI STATE UNIVERSITY (Starkville, MS) THE TEXAS A&M UNIVERSITY SYSTEM (College Station, TX) 2034-09-12 DISCN search
Merck ELSPAR asparaginase VIAL 101063 001 1978-01-10   Start Trial MISSISSIPPI STATE UNIVERSITY (Starkville, MS) THE TEXAS A&M UNIVERSITY SYSTEM (College Station, TX) 2034-09-12 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 001 1986-06-04   Start Trial MISSISSIPPI STATE UNIVERSITY (Starkville, MS) THE TEXAS A&M UNIVERSITY SYSTEM (College Station, TX) 2034-09-12 RX search
Schering INTRON A interferon alfa-2b VIAL 103132 002 1986-06-04   Start Trial MISSISSIPPI STATE UNIVERSITY (Starkville, MS) THE TEXAS A&M UNIVERSITY SYSTEM (College Station, TX) 2034-09-12 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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