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Last Updated: December 29, 2025

Claims for Patent: 10,258,679

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Summary for Patent: 10,258,679

Title:	Recombinant Listeria vaccine strains and methods of producing the same
Abstract:	The present invention provides methods of treating, protecting against and inducing an immune response against a tumor or cancer, comprising the step of administering to a subject a recombinant Listeria strain. In one embodiment the present invention relates to a recombinant Listeria strain, said recombinant Listeria strain comprising a recombinant nucleic add, said nucleic add comprising a first open reading frame encoding a recombinant polypeptide comprising a first N-terminal fragment of an LLO protein fused to a heterologous antigen or fragment thereof, and wherein said recombinant nucleic add further comprises a second open reading frame encoding a mutant PrfA protein.
Inventor(s):	Anu Wallecha, Robert Petit
Assignee:	Ayala Pharmaceuticals Inc
Application Number:	US15/306,289

Details for Patent 10,258,679

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Eli Lilly And Company	TALTZ	ixekizumab	Injection	125521	March 22, 2016	10,258,679	2035-04-14
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 10,258,679

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Country	Patent Number	Estimated Expiration
World Intellectual Property Organization (WIPO)	2015164121	⤷ Get Started Free
United States of America	2019240303	⤷ Get Started Free
United States of America	2017042996	⤷ Get Started Free
>Country	>Patent Number	>Estimated Expiration

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