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Last Updated: April 26, 2024

Claims for Patent: 10,206,956

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Summary for Patent: 10,206,956

Title:	Compositions and methods for reducing frequency and/or severity of headache
Abstract:	In one embodiment, the present invention relates to a method for reducing the frequency and/or severity of headache in a subject comprising administering to the subject a composition comprising the stromal vascular fraction or stromal cells of adipose tissue. In another embodiment, the present invention relates to a method for reducing the frequency and/or severity of headache in a subject comprising administering to the subject a composition compositing bone marrow. In another embodiment, the present invention relates to a method for reducing the frequency or severity of headache in a subject comprising administering to the subject a composition comprising adult stem cells.
Inventor(s):	Bright; Ralph (Liverpool, AU), Bright; Pelin (Liverpool, AU), Hansen; Bruce (Liverpool, AU), Thomas; Wayne (Liverpool, AU)
Assignee:	Rusty Property Holdings Pty Ltd. (Liverpool, AU) Amberdale Enterprises Pty Ltd. (Bar Beach, AU) Tavid Pty Ltd. (Merewether, AU)
Application Number:	14/409,173
Patent Claims:	1. A method of reducing the frequency of migraine and/or tension headache, and/or the severity of recurrent migraine and/or tension headache, in a subject in need thereof comprising administering intravenously to the subject a composition comprising: the stromal vascular fraction or stromal cells of adipose tissue; or a bone marrow-derived preparation of cells, wherein the stromal vascular fraction or stromal cells of adipose tissue or the bone marrow-derived preparation of cells comprises adult stem cells, wherein the adult stem cells are mesenchymal stem cells and/or early mesenchymal/stromal precursor cells, and/or adipose issue-derived stromal/stem cells. 2. The method according to claim 1 wherein the adipose tissue or bone marrow is autologous. 3. The method according to claim 1 wherein the adipose tissue or bone marrow is allogeneic. 4. The method according to claim 1 wherein the adipose tissue is treated with an enzyme and/or dissociating reagent. 5. The method according to claim 4 wherein the enzyme is collagenase and the dissociating reagent is lecithin. 6. The method according to claim 1 wherein the adipose tissue is subjected to ultrasonic cavitation. 7. The method according to claim 6 wherein the ultrasonic cavitation lyses adipocytes. 8. The method according to claim 1 wherein the adipose tissue is subjected to mechanical agitation. 9. The method according to claim 1 wherein the stromal vascular fraction or stromal cells of adipose tissue or the bone marrow-derived preparation of cells is treated with platelet-rich plasma or plasma rich in growth factors. 10. A method of reducing the frequency of migraine and/or tension headache, and/or the severity of recurrent migraine and/or tension headache, in a subject in need thereof comprising administering intravenously to the subject a composition comprising adult stem cells, wherein the adult stem cells are mesenchymal stem cells and/or early mesenchymal/stromal precursor cells and/or adipose tissue-derived stromal/stem cells. 11. The method according to claim 1 or claim 10 the adult stem cells have been expanded and/or cultured. 12. The method according to claim 10, wherein the mesenchymal stem cells and/or early mesenchymal/stromal precursor cells are obtained from adipose tissue, bone marrow or blood. 13. The method according to claim 10 wherein the adult stem cells are autologous. 14. The method according to claim 10 wherein the adult stem cells are allogeneic. 15. The method according to claim 10 wherein the adult stem cells are treated with platelet-rich plasma or plasma rich in growth factors.

Details for Patent 10,206,956

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Smith & Nephew, Inc.	SANTYL	collagenase	Ointment	101995	06/04/1965	⤷ Try a Trial	2032-06-26
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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