Claims for Patent: 10,166,290
✉ Email this page to a colleague
Summary for Patent: 10,166,290
Title: | Intralesional (Intratumoral) dinitrochlorobenzene and associated compounds coadministered with checkpoint inhibitors for cancer treatment including treatment of metastatic cutaneous cancers |
Abstract: | Inventor seeks patents related to the use in solid cancer patients of substances, (including, for example, dinitrohalogenated compounds) injected into tumor nodules in association with treatment with one or more checkpoint inhibitors that are administered before, during or after the intralesional (intratumoral) injection or injections. |
Inventor(s): | Cohen; Max H. (Potomac, MD) |
Assignee: | |
Application Number: | 15/442,615 |
Patent Claims: | 1. A method of treating a primary or recurrent cancerous nodule or nodules in a subject comprising administering an intralesional injection of compounds
including dinitrohalogenated benzene in association with the use of previous, subsequent, or simultaneous administration of a checkpoint inhibitor selected from the group consisting of ipilimumab, pembrolizumab, nivolumab and tremelimumab.
2. The method of claim 1 wherein the dinitrohalogenated benzene is administered in a diluent or vehicle. 3. The method of claim 1 wherein the cancerous nodule is a solid tumor in cutaneous or non-cutaneous locations. 4. The method of claim 3 wherein the solid tumor is melanoma, breast cancer, squamous cancer, or non-small cell lung cancer. 5. The method of claim 1 wherein the dinitrohalogenated benzene is dinitrochlorobenzene or dinitrofluorobenzene. 6. The method of claim 1 wherein multiple intralesional agents including dinitrohalogenated benzene are injected. 7. The method of claim 1 wherein the cancerous nodule or nodules represent distant or local tumor. 8. A method of treating malignant nodules comprising co-administration of a checkpoint inhibitor selected from the group consisting of ipilimumab, pembrolizumab, nivolumab and tremelimumab either before, during or after administration of an intralesional injection of dinitrohalogenated benzene, wherein the most superficial area of the injected nodule becomes raised as the intralesional injection is administered. 9. The method of claim 1 wherein the subject does not have clinical, radiological or laboratory evidence of the spread of cancer beyond the adjacent regional lymph nodes consisting of the neck, axillary or groin nodes closest to the primary cancer site. 10. The method of claim 1 further comprising administering another intralesional compound or compounds. 11. The method of claim 2 wherein the diluent is acetone or olive oil. |
Details for Patent 10,166,290
Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
---|---|---|---|---|---|---|---|
Bristol-myers Squibb Company | YERVOY | ipilimumab | Injection | 125377 | 03/25/2011 | ⤷ Try a Trial | 2039-02-26 |
Merck Sharp & Dohme Corp. | KEYTRUDA | pembrolizumab | For Injection | 125514 | 09/04/2014 | ⤷ Try a Trial | 2039-02-26 |
Merck Sharp & Dohme Corp. | KEYTRUDA | pembrolizumab | Injection | 125514 | 01/15/2015 | ⤷ Try a Trial | 2039-02-26 |
>Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
Make Better Decisions: Try a trial or see plans & pricing
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.