Claims for Patent: 10,099,996

Summary for Patent: 10,099,996

Title:	Compositions and methods of use of phorbol esters in the treatment of neoplasms
Abstract:	Methods and compositions containing a phorbol ester or a derivative of a phorbol ester are provided for the treatment of chronic and acute conditions. Such conditions may be caused by disease, be symptoms, treatments, or sequelae of disease. The phorbol esters described are particularly useful in the treatment of neoplastic diseases and/or managing the side effects of chemotherapeutic and radiotherapeutic treatments of neoplastic diseases.
Inventor(s):	Han; Zheng Tao (Eugene, OR), Chen; Hung-Fong (Taipei, TW)
Assignee:	Biosuccess Biotech Co. Ltd. (Santa Clara, CA)
Application Number:	14/025,206
Patent Claims:	1. A method of treating neoplasms comprising administering parenterally to a mammalian subject with lung cancer, an effective amount of a phorbol ester of Formula II, or a pharmaceutically acceptable salt, isomer, or enantiomer thereof, ##STR00052## and at least one secondary or adjunctive therapeutic agent; wherein said effective amount is between about 10 .mu.g to about 1500 .mu.g of said phorbol ester of Formula II, administered every other day, and for at least a total of 5 times; and wherein one or more symptoms or conditions suffered by the mammalian subject is alleviated or treated, the one or more symptoms being selected from the group consisting of chronic fatigue, excessive or easy bleeding, easy bruising, shortness of breath, petechiae, recurrent fever, swollen gums, slow healing of cuts, bone and joint discomfort, recurrent infections, weight loss, itching, night sweats, lymph node swelling, fever, abdominal pain and discomfort, disturbances in vision, coughing, loss of appetite, pain in the chest, difficulty swallowing, swelling, a need to urinate frequently, difficulty starting urination, difficulty holding back urine, weak or interrupted flow of urine, painful or burning urination, difficulty in having an erection, painful ejaculation, blood in urine or semen, frequent pain or stiffness, and weakness. 2. The method of claim 1, wherein two secondary or adjunctive therapeutic agents are administered to said subject. 3. The method of claim 2, wherein the two secondary or adjunctive therapeutic agents are dexamethasone and choline magnesium trisalicylate. 4. A method of treating neoplasms comprising administering parenterally to a mammalian subject with lymphoma, an effective amount of a phorbol ester of Formula II, or a pharmaceutically acceptable salt, isomer, or enantiomer thereof, ##STR00053## and at least one secondary or adjunctive therapeutic agent; wherein said effective amount is between about 10 .mu.g to about 1500 .mu.g of said phorbol ester of Formula II, administered every other day and wherein said phorbol ester of Formula II is administered for at least a total of 5 times; and wherein one or more symptoms or conditions suffered by the mammalian subject is alleviated or treated, the one or more symptoms being selected from the group consisting of chronic fatigue, excessive or easy bleeding, easy bruising, shortness of breath, petechiae, recurrent fever, swollen gums, slow healing of cuts, bone and joint discomfort, recurrent infections, weight loss, itching, night sweats, lymph node swelling, fever, abdominal pain and discomfort, disturbances in vision, coughing, loss of appetite, pain in the chest, difficulty swallowing, swelling, a need to urinate frequently, difficulty starting urination, difficulty holding back urine, weak or interrupted flow of urine, painful or burning urination, difficulty in having an erection, painful ejaculation, blood in urine or semen, frequent pain or stiffness, and weakness. 5. A method of treating neoplasms comprising administering parenterally to a mammalian subject with breast cancer, an effective amount of a phorbol ester of Formula II, or a pharmaceutically acceptable salt, isomer, or enantiomer thereof, ##STR00054## and at least one secondary or adjunctive therapeutic agent; wherein said effective amount is between about 10 .mu.g to about 1500 .mu.g of said phorbol ester of Formula II, administered every other day and wherein said phorbol ester of Formula II is administered for at least a total of 5 times; and wherein one or more symptoms or conditions suffered by the mammalian subject is alleviated or treated, the one or more symptoms being selected from the group consisting of chronic fatigue, excessive or easy bleeding, easy bruising, shortness of breath, petechiae, recurrent fever, swollen gums, slow healing of cuts, bone and joint discomfort, recurrent infections, weight loss, itching, night sweats, lymph node swelling, fever, abdominal pain and discomfort, disturbances in vision, coughing, loss of appetite, pain in the chest, difficulty swallowing, swelling, a need to urinate frequently, difficulty starting urination, difficulty holding back urine, weak or interrupted flow of urine, painful or burning urination, difficulty in having an erection, painful ejaculation, blood in urine or semen, frequent pain or stiffness, and weakness. 6. A method of treating neoplasms comprising administering parenterally to a mammalian subject with liver cancer, an effective amount of a phorbol ester of Formula II, or a pharmaceutically acceptable salt, isomer, or enantiomer thereof, ##STR00055## and at least one secondary or adjunctive therapeutic agent; wherein said effective amount is between about 10 .mu.g to about 1500 .mu.g of said phorbol ester of Formula II, administered every other day and wherein said phorbol ester of Formula II is administered for at least a total of 5 times; and wherein one or more symptoms or conditions suffered by the mammalian subject is alleviated or treated, the one or more symptoms being selected from the group consisting of chronic fatigue, excessive or easy bleeding, easy bruising, shortness of breath, petechiae, recurrent fever, swollen gums, slow healing of cuts, bone and joint discomfort, recurrent infections, weight loss, itching, night sweats, lymph node swelling, fever, abdominal pain and discomfort, disturbances in vision, coughing, loss of appetite, pain in the chest, difficulty swallowing, swelling, a need to urinate frequently, difficulty starting urination, difficulty holding back urine, weak or interrupted flow of urine, painful or burning urination, difficulty in having an erection, painful ejaculation, blood in urine or semen, frequent pain or stiffness, and weakness. 7. A method of treating neoplasms comprising administering parenterally to a mammalian subject with pancreatic cancer, an effective amount of a phorbol ester of Formula II, or a pharmaceutically acceptable salt, isomer, or enantiomer thereof, ##STR00056## and at least one secondary or adjunctive therapeutic agent; wherein said effective amount is between about 10 .mu.g to about 1500 .mu.g of said phorbol ester of Formula II, administered every other day and wherein said phorbol ester of Formula II is administered for at least a total of 5 times; and wherein one or more symptoms or conditions suffered by the mammalian subject is alleviated or treated, the one or more symptoms being selected from the group consisting of chronic fatigue, excessive or easy bleeding, easy bruising, shortness of breath, petechiae, recurrent fever, swollen gums, slow healing of cuts, bone and joint discomfort, recurrent infections, weight loss, itching, night sweats, lymph node swelling, fever, abdominal pain and discomfort, disturbances in vision, coughing, loss of appetite, pain in the chest, difficulty swallowing, swelling, a need to urinate frequently, difficulty starting urination, difficulty holding back urine, weak or interrupted flow of urine, painful or burning urination, difficulty in having an erection, painful ejaculation, blood in urine or semen, frequent pain or stiffness, and weakness. 8. A method of treating neoplasms comprising administering parenterally to a mammalian subject with cervical cancer, an effective amount of a phorbol ester of Formula II, or a pharmaceutically acceptable salt, isomer, or enantiomer thereof, ##STR00057## and at least one secondary or adjunctive therapeutic agent; wherein said effective amount is between about 10 .mu.g to about 1500 .mu.g of said phorbol ester of Formula II, administered every other day and wherein said phorbol ester of Formula II is administered for at least a total of 5 times; and wherein one or more symptoms or conditions suffered by the mammalian subject is alleviated or treated, the one or more symptoms being selected from the group consisting of chronic fatigue, excessive or easy bleeding, easy bruising, shortness of breath, petechiae, recurrent fever, swollen gums, slow healing of cuts, bone and joint discomfort, recurrent infections, weight loss, itching, night sweats, lymph node swelling, fever, abdominal pain and discomfort, disturbances in vision, coughing, loss of appetite, pain in the chest, difficulty swallowing, swelling, a need to urinate frequently, difficulty starting urination, difficulty holding back urine, weak or interrupted flow of urine, painful or burning urination, difficulty in having an erection, painful ejaculation, blood in urine or semen, frequent pain or stiffness, and weakness. 9. A method of treating neoplasms comprising administering parenterally to a mammalian subject with multiple myeloma, an effective amount of a phorbol ester of Formula II, or a pharmaceutically acceptable salt, isomer, or enantiomer thereof, ##STR00058## and at least one secondary or adjunctive therapeutic agent; wherein said effective amount is between about 10 .mu.g to about 1500 .mu.g of said phorbol ester of Formula II, administered every other day and wherein said phorbol ester of Formula II is administered for at least a total of 5 times; and wherein one or more symptoms or conditions suffered by the mammalian subject is alleviated or treated, the one or more symptoms being selected from the group consisting of chronic fatigue, excessive or easy bleeding, easy bruising, shortness of breath, petechiae, recurrent fever, swollen gums, slow healing of cuts, bone and joint discomfort, recurrent infections, weight loss, itching, night sweats, lymph node swelling, fever, abdominal pain and discomfort, disturbances in vision, coughing, loss of appetite, pain in the chest, difficulty swallowing, swelling, a need to urinate frequently, difficulty starting urination, difficulty holding back urine, weak or interrupted flow of urine, painful or burning urination, difficulty in having an erection, painful ejaculation, blood in urine or semen, frequent pain or stiffness, and weakness. 10. The method of any one of claim 1, 5, 6, 7, 8, or 9, wherein the at least one secondary or adjunctive therapeutic agent is administered to said subject in a coordinate administration protocol, simultaneously with, prior to, or after, administration of said phorbol ester to said subject. 11. The method of any one of claim 1, 4, 5, 6, 7, 8, or 9, wherein the at least one secondary or adjunctive therapeutic agent is selected from the group consisting of: doxorubicin, vitamin D3, cytarabine, cytosine arabinoside, daunorubicin, cyclophosphamide, gemtuzumab ozogamicin, idarubicin, mercaptopurine, mitoxantrone, thioguanine, aldesleukin, asparaginase, carboplatin, etoposide phosphate, fludarabine, methotrexate, etoposide, dexamethasone, and choline magnesium trisalicylate.

Details for Patent 10,099,996

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Recordati Rare Diseases, Inc.	ELSPAR	asparaginase	For Injection	101063	01/10/1978		2032-01-18
Clinigen, Inc.	PROLEUKIN	aldesleukin	For Injection	103293	05/05/1992		2032-01-18
Wyeth Pharmaceuticals Llc	MYLOTARG	gemtuzumab ozogamicin	For Injection	761060	09/01/2017		2032-01-18