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Last Updated: March 29, 2024

Claims for Patent: 10,016,434


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Summary for Patent: 10,016,434
Title:Methods for the treatment of HER2 amplified cancer
Abstract: Described herein are methods and compositions for treating HER2-amplified cancer. The methods include administering to an individual in need thereof ibrutinib.
Inventor(s): Chen; Jun (San Jose, CA), Buggy; Joseph J. (Mountain View, CA), Elias; Laurence (Berkeley, CA)
Assignee: Pharmacyclics LLC (Sunnyvale, CA)
Application Number:15/652,470
Patent Claims:1. A method for treating HER2 amplified cancer in an individual in need thereof, wherein the cancer is selected from the group consisting of colon, lung, and pancreatic cancers, and the method comprises administering to the individual in need thereof a composition comprising 1-(R)-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)pi- peridin-1-yl)prop-2-en-1-one ##STR00018## or a pharmaceutically acceptable salt thereof.

2. The method of claim 1, wherein the HER2-amplified cancer is metastatic.

3. The method of claim 1, wherein the HER2-amplified cancer has a HER2:CEP17 ratio of 2.2-4.0 or >4.0.

4. The method of claim 1, wherein the HER2-amplified cancer is refractory to treatment.

5. The method of claim 1, further comprising co-administering an additional therapeutic agent.

6. The method of claim 5, wherein the additional therapeutic agent is an anti-HER2 therapeutic agent, a pan-ErbB inhibitor, or an anti-VEGF therapeutic agent.

7. The method of claim 6, wherein the anti-HER2 therapeutic agent is selected from the group consisting of trastuzumab, trastuzumab emtansine, pertuzumab, lapatinib, and MM-111.

8. The method of claim 6, wherein the pan-ErbB inhibitor is selected from the group consisting of afatinib, neratinib, and dacomitinib.

9. The method of claim 6, wherein the anti-VEGF therapeutic agent is selected from the group consisting of bevacizumab, ranibizumab, lapatinib, sunitinib, sorafenib, axitinib, and pazopanib.

10. The method of claim 5, wherein the additional therapeutic agent is selected from the group consisting of: temsirolimus; paclitaxel; ASLAN001; vorinostat; doxorubicin; cyclophosphamide; cisplatin; docetaxel; dasatinib; trastuzumab and docetaxel; pertuzumab and docetaxel; doxorubicin, cyclophosphamide and paclitaxal; and doxorubicin, cyclophosphamide and fluorouracil.

11. The method of claim 1, wherein the HER2-amplified cancer is colon cancer.

12. The method of claim 1, wherein the HER2-amplified cancer is lung cancer.

13. The method of claim 1, wherein the HER2-amplified cancer is pancreatic cancer.

14. The method of claim 1, wherein the composition comprises ibrutinib.

Details for Patent 10,016,434

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Genentech, Inc. HERCEPTIN trastuzumab For Injection 103792 09/25/1998 ⤷  Try a Trial 2033-08-12
Genentech, Inc. HERCEPTIN trastuzumab For Injection 103792 02/10/2017 ⤷  Try a Trial 2033-08-12
Genentech, Inc. AVASTIN bevacizumab Injection 125085 02/26/2004 ⤷  Try a Trial 2033-08-12
Genentech, Inc. LUCENTIS ranibizumab Injection 125156 06/30/2006 ⤷  Try a Trial 2033-08-12
Genentech, Inc. LUCENTIS ranibizumab Injection 125156 08/10/2012 ⤷  Try a Trial 2033-08-12
Genentech, Inc. LUCENTIS ranibizumab Injection 125156 10/13/2016 ⤷  Try a Trial 2033-08-12
Genentech, Inc. LUCENTIS ranibizumab Injection 125156 03/20/2018 ⤷  Try a Trial 2033-08-12
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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