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Last Updated: March 28, 2024

Claims for Patent: 10,010,508


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Summary for Patent: 10,010,508
Title:MTAB-TA-Coated gold nanorods and method of fabrication
Abstract: 11-mercaptoundecyl trimethylammonium bromide gold nanorod (MTAB-GNR) coated with tannic acid (TA), useful for biological cellular imaging. A method of synthesizing tannic acid-coated 11-mercaptoundecyl trimethylammonium bromide gold nanorods (MTAB-TA GNRs) comprising presenting 11-mercaptoundecyl trimethylammonium bromide gold nanorods (MTAB-GNRs) in solution; functionalizing the MTAB-GNRs with tannic acid (TA) added to the MTAB-GNRs, the tannic acid configured to form a coating around the MTAB-GNRs forming MTAB-TA GNRs. The functionalizing step may further comprise adding a sodium chloride solution to the MTAB-TA GNR solution, and/or adding a MOPS buffer to the solution of tannic acid with MTAB-GNRs, and the tannic acid MTAB-GNR solution may be vortexed after each step. The MTAB-TA GNR solution may be centrifuged to separate the MTAB-TA GNRs from residual tannic acid and supernatant, and sterile water may be added to the MTAB-TA GNR solution and centrifuging performed to remove residual tannic acid from the MTAB-TA GNRs.
Inventor(s): Polito; Anthony B (Springboro, OH), Hussain; Saber M (Beavercreek, OH)
Assignee: The United States of America as represented by the Secretary of the Air Force (Washington, DC)
Application Number:15/379,581
Patent Claims:1. An 11-mercaptoundecyl trimethylammonium bromide gold nanorod (MTAB-GNR) coated with tannic acid (TA).

2. A method of synthesizing tannic acid-coated 11-mercaptoundecyl trimethylammonium bromide gold nanorods (MTAB-TA GNRs), the method comprising: presenting one or more 11-mercaptoundecyl trimethylammonium bromide gold nanorods (MTAB-GNRs) in solution; and functionalizing the MTAB-GNRs with tannic acid (TA) added to the MTAB-GNRs in solution, wherein the tannic acid is configured to form a coating around the MTAB-GNRs and MTAB-TA GNRs are formed.

3. The method of synthesizing tannic acid-coated 11-mercaptoundecyl trimethylammonium bromide gold nanorods (MTAB-TA GNRs) of claim 2, wherein the functionalizing step further comprises: vortexing the tannic acid MTAB-GNR solution.

4. The method of synthesizing tannic acid-coated 11-mercaptoundecyl trimethylammoniurn bromide gold nanorods (MTAB-TA GNRs) of claim 2, wherein the functionalizing step further comprises: adding a solution of sodium chloride to the solution of tannic acid with MTAB-GNRs.

5. The method of synthesizing tannic acid-coated 11-mercaptoundecyl trimethylammonium bromide gold nanorods (MTAB-TA GNRs) of claim 4, wherein the functionalizing step further comprises: vortexing the tannic acid MTAB-GNR solution.

6. The method of synthesizing tannic acid-coated 11-mercaptoundecyl trimethylammonium bromide gold nanorods (MTAB-TA GNRs) of claim 4, wherein the functionalizing step further comprises: adding a MOPS buffer (3-(A-morpholino)propanesulfonic acid) to the solution of tannic acid with MTAB-GNRs.

7. The method of synthesizing tannic acid-coated 11-mercaptoundecyl trimethylammonium bromide gold nanorods (MTAB-TA GNRs) of claim 6, wherein the functionalizing step further comprises: vortexing the tannic acid MTAB-GNR solution.

8. The method of synthesizing tannic acid-coated 11-mercaptoundecyl trimethylammonium bromide gold nanorods (MTAB-TA GNRs) of claim 6, wherein the functionalizing step further comprises: centrifuging the MTAB-TA GNR solution to separate the MTAB-TA GNRs from residual tannic acid and supernatant.

9. The method of synthesizing tannic acid-coated 11-mercaptoundecyl trimethylammonium bromide gold nanorods (MTAB-TA GNRs) of claim 8, wherein the functionalizing step further comprises: adding sterile water to the MTAB-TA GNR solution and centrifuging to remove residual tannic acid from the MTAB-TA GNRs.

10. The method of synthesizing tannic acid-coated 11-mercaptoundecyl trimethylammonium bromide gold nanorods (MTAB-TA GNRs) of claim 2, wherein the functionalizing step further comprises: adding a solution of sodium chloride to the solution of tannic acid with MTAB-GNRs; adding a MOPS buffer (3-(A-morpholino)propanesulfonic acid) to the solution of tannic acid with MTAB-GNRs; and centrifuging the MTAB-TA GNR solution to separate the MTAB-TA GNRs from residual tannic acid and supernatant.

11. The method of synthesizing tannic acid-coated 11-mercaptoundecyl trimethylammoniurn bromide gold nanorods (MTAB-TA GNRs) of claim 10, wherein the functionalizing step further comprises: vortexing the tannic acid MTAB-GNR solution after each addition.

12. The method of synthesizing tannic acid-coated 11-mercaptoundecyl trimethylammonium bromide gold nanorods (MTAB-TA GNRs) of claim 10, wherein the functionalizing step further comprises: adding sterile water to the MTAB-TA GNR solution and centrifuging to remove residual tannic acid from the MTAB-TA GNRs.

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