Last Updated: November 8, 2026

Biologic Drugs With Established Pharmaceutical Class: Human Blood Coagulation Factor

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Patent Expiration
Baxter Healthcare Corporation	TISSEEL	fibrin sealant (tisseel)	For Injection	103980	2000-02-07	⤷ Start Trial	⤷ Start Trial
Omrix Biopharmaceuticals Ltd	EVITHROM	thrombin, topical (human)	Solution	125247	2007-08-27	⤷ Start Trial	⤷ Start Trial
Omrix Biopharmaceuticals Ltd	EVITHROM	thrombin, topical (human)	Solution	125247	2007-08-27	12,311,015	⤷ Start Trial
Omrix Biopharmaceuticals Ltd	EVITHROM	thrombin, topical (human)	Solution	125247	2007-08-27	9,028,851	⤷ Start Trial
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Patent Expiration

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