National Institute of Allergy and Infectious Diseases (NIAID)
Phase 1
2006-02-01
The purpose of this research study is to see if giving a typhoid vaccine by mouth (an
experimental vaccine, CVD 909) before giving a vaccine shot (Typhim Vi) will result in a
better immune response than giving Typhim Vi vaccine by itself. Another purpose is to see
whether CVD 909 is safe. Typhim Vi has been shown to be safe and effective in preventing
typhoid fever in older children and adults, but it does not work in children under age 2.
Scientists at the University of Maryland think that young children could respond to Typhim Vi
if they were given a dose of the other typhoid vaccine by mouth before they are given the
Typhim Vi shot. Twenty-eight healthy adult volunteers, ages 18-40 years, will take part in
this study. Study participation will last for up to 63 weeks, but most of the study visits
will be in the first 6 weeks. Blood samples will be collected approximately 13 times. Four
stool samples will be collected. Some volunteers may be followed for an additional 4 years.
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