Amlodipine Plus Botulinum Toxin for Focal Dystonia
National Institute of Neurological Disorders and Stroke (NINDS)
Objective: To determine if the calcium channel blockers, amlodipine can augment the effect
of botulinum toxin injections in the treatment of focal dystonia.
Study Population: 20 patients with cervical dystonia
Design: Double-bind, placebo-controlled clinical trail.
Outcome measures: For patients: dystonia rating scales (Twistrs, Fahn-Marsden dystonia
scale, NINDS subjective patient rating scale), and hand grip strength. For healthy
volunteers: Amplitude of EDB MEP.
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
This study examines botulinum toxin (BOTOX, or BTX) for the treatment of muscle twitches and
spasticity associated with cerebral palsy in children. Botulinum toxin is a naturally
occurring bacterial toxin (botulinum toxin) that inactivates certain parts of muscles.
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