Alendronate and/or Parathyroid Hormone for Osteoporosis
Completed
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Phase 2
1999-08-01
This study looks at the effects of two medications, alendronate and parathyroid hormone, on
bone mass and on bone formation and bone breakdown in women with osteoporosis. We will
randomly select postmenopausal women who have osteoporosis to receive laboratory-produced
human parathyroid hormone (hPTH), or alendronate, or both for 2.5 years. Study participants
will return to the study center periodically to have their bone mass measured and to give
blood and urine samples for tests of bone formation and breakdown and for other laboratory
tests. Those who complete the study are eligible for one or two 12 month extension studies.
Alendronate and/or Parathyroid Hormone for Osteoporosis
Completed
Massachusetts General Hospital
Phase 2
1999-08-01
This study looks at the effects of two medications, alendronate and parathyroid hormone, on
bone mass and on bone formation and bone breakdown in women with osteoporosis. We will
randomly select postmenopausal women who have osteoporosis to receive laboratory-produced
human parathyroid hormone (hPTH), or alendronate, or both for 2.5 years. Study participants
will return to the study center periodically to have their bone mass measured and to give
blood and urine samples for tests of bone formation and breakdown and for other laboratory
tests. Those who complete the study are eligible for one or two 12 month extension studies.
Effects of Parathyroid Hormone in Men With Osteoporosis
Completed
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Phase 3
1999-09-01
Alendronate is a drug that blocks or reduces bone loss, while parathyroid hormone (PTH)
stimulates the formation of new bone. The purpose of this study is to compare the
bone-building effects of PTH alone, alendronate alone, and both PTH and alendronate in men
with osteoporosis over a two-and-a-half year period.
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