LUMIFY Drug Patent Profile

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Which patents cover Lumify, and what generic alternatives are available?

Lumify is a drug marketed by Bausch And Lomb Inc and is included in two NDAs. There are six patents protecting this drug and one Paragraph IV challenge.

The generic ingredient in LUMIFY is brimonidine tartrate. Seventeen suppliers are listed for this compound. Additional details are available on the brimonidine tartrate profile page.

DrugPatentWatch^® Litigation and Generic Entry Outlook for Lumify

A generic version of LUMIFY was approved as brimonidine tartrate by BAUSCH AND LOMB INC on May 28^th, 2003.

Summary for LUMIFY

US Patents:	5
Applicants:	1
NDAs:	2
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for LUMIFY

Paragraph IV (Patent) Challenges for LUMIFY

Tradename	Dosage	Ingredient	Strength	NDA	ANDAs Submitted	Submissiondate
LUMIFY	Ophthalmic Solution	brimonidine tartrate	0.025%	208144	1	2021-07-12

US Patents and Regulatory Information for LUMIFY

LUMIFY is protected by five US patents.

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Exclusivity Expiration
Bausch And Lomb Inc	LUMIFY	brimonidine tartrate	SOLUTION/DROPS;OPHTHALMIC	208144-001	Dec 22, 2017		OTC	Yes	Yes
Bausch And Lomb Inc	LUMIFY PRESERVATIVE FREE	brimonidine tartrate	SOLUTION/DROPS;OPHTHALMIC	218424-001	Apr 19, 2024		OTC	Yes	Yes
Bausch And Lomb Inc	LUMIFY	brimonidine tartrate	SOLUTION/DROPS;OPHTHALMIC	208144-001	Dec 22, 2017		OTC	Yes	Yes
Bausch And Lomb Inc	LUMIFY PRESERVATIVE FREE	brimonidine tartrate	SOLUTION/DROPS;OPHTHALMIC	218424-001	Apr 19, 2024		OTC	Yes	Yes
Bausch And Lomb Inc	LUMIFY	brimonidine tartrate	SOLUTION/DROPS;OPHTHALMIC	208144-001	Dec 22, 2017		OTC	Yes	Yes
Bausch And Lomb Inc	LUMIFY	brimonidine tartrate	SOLUTION/DROPS;OPHTHALMIC	208144-001	Dec 22, 2017		OTC	Yes	Yes
Bausch And Lomb Inc	LUMIFY PRESERVATIVE FREE	brimonidine tartrate	SOLUTION/DROPS;OPHTHALMIC	218424-001	Apr 19, 2024		OTC	Yes	Yes

International Patents for LUMIFY

See the table below for patents covering LUMIFY around the world.

Country	Patent Number	Title	Estimated Expiration
Brazil	112016004054	composições e métodos para o tratamento de condições nasais
Canada	2732521	COMPOSITIONS DE VASOCONSTRICTION, ET PROCEDES D'UTILISATION (VASOCONSTRICTION COMPOSITIONS AND METHODS OF USE)
Canada	2782817	COMPOSITIONS ET METHODES DE BLANCHIMENT DES YEUX (COMPOSITIONS AND METHODS FOR EYE WHITENING)
Canada	2832953	COMPOSITIONS ET METHODES UTILISEES DE TRAITEMENT D'AFFECTIONS NASALES (COMPOSITIONS AND METHODS FOR THE TREATMENT OF NASAL CONDITIONS)
Canada	2865593	COMPOSITIONS ET METHODES POUR LE TRAITEMENT DE LA MIGRAINE (COMPOSITIONS AND METHODS FOR THE TREATMENT OF MIGRAINE)
Cyprus	1115727
Denmark	2320911

Supplementary Protection Certificates for LUMIFY

Patent Number	Supplementary Protection Certificate	SPC Country	SPC Expiration	SPC Description
1631293	C300683	Netherlands		PRODUCT NAME: BRIMONIDINE EN FARMACEUTISCH AANVAARDBARE ZOUTEN DAARVAN VOOR TOEPASSING ALS GENEESMIDDEL VOOR DE BEHANDELING VAN DOOR ROSACEA GEINDUCEERDE ROODHEID; REGISTRATION NO/DATE: EU/1/13/904 20140225
1631293	300683	Netherlands		PRODUCT NAME: BRIMONIDINE EN FARMACEUTISCH AANVAARDBARE ZOUTEN DAARVAN VOOR TOEPASSING ALS GENEESMIDDEL VOOR DE BEHANDELING VAN DOOR ROSACEA GEINDUCEERDE ROODHEID; REGISTRATION NO/DATE: EU/1/13/904 20140225
1631293	2014/041	Ireland		PRODUCT NAME: BRIMONIDINE AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF; REGISTRATION NO/DATE: EU/1/13/904 20140221
1631293	201440029	Slovenia		PRODUCT NAME: BRIMONIDINE AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS; NATIONAL AUTHORISATION NUMBER: EU/1/13/904/001-003; DATE OF NATIONAL AUTHORISATION: 20140221; AUTHORITY FOR NATIONAL AUTHORISATION: EU
1631293	92462	Luxembourg		PRODUCT NAME: BRIMONIDINE ET SES SELS PHARMACEUTIQUES POUR L UTILISATION COMME MEDICAMENT POUR LE TRAITEMENT DES ROUGEURS INDUITES PAR LA ROSACEA.FIRST REGISTRATION: 20140225
1631293	2014C/042	Belgium		PRODUCT NAME: MIRVASO (BRIMONIDINE) EN FARMACEUTISCHE ZOUTEN DAARVAN VOOR GEBRUIK ALS MEDICIJN VOOR HET BEHANDELEN VAN ROSACEA GEINDUCEERDE ROODHEID; AUTHORISATION NUMBER AND DATE: EU/1/13/904 20140221
1631293	14C0056	France		PRODUCT NAME: BRIMONIDINE OU L'UN DE SES SELS PHARMACEUTIQUEMENT ACCEPTABLES; REGISTRATION NO/DATE: EU/1/13/904 20140225

Investment Scenario and Fundamentals Analysis for LUMIFY

Last updated: February 20, 2026

What is LUMIFY and its Market Position?

LUMIFY (brimonidine tartrate ophthalmic solution 0.025%) is a prescription eye drop manufactured by Bausch + Lomb. It is marketed primarily for decreasing eye redness caused by minor eye irritations, dryness, and allergies. Launched in 2018, LUMIFY has gained a foothold in the OTC blepharitis, blepharoconjunctivitis, and ocular redness treatment segments.

The product is positioned to compete with both OTC redness relievers and prescription treatments for more chronic conditions like ocular rosacea. LUMIFY’s differentiator lies in its targeted mechanism of vasoconstriction with minimal rebound redness, a common issue with OTC vasoconstrictors.

Market Overview and Revenue Drivers

• Estimated US ophthalmic redness treatment market was valued at $800 million in 2022, with an expected CAGR of 4.5% through 2027.[1]

• LUMIFY’s initial launch targeted the approximately 20 million adults with mild eye redness annually in the US.[2]

• Bausch + Lomb reported LUMIFY generating approximately $200M in net sales in 2022, representing roughly 25% of the company's US ophthalmic prescription revenue.[3]

• The drug’s growth trajectory depends heavily on market penetration, physician prescribing patterns, and consumer adoption.

Fundamentals and Financials

Revenue Streams and Market Penetration

Aspect	Data Point	Analysis
US Sales (2022)	~$200 million	Significant for a relatively recent product launch
Prescription share	Estimated 15-20% in the redness segment	Indicates room for growth with increased physician adoption
Refill rate	Approx. 70% of prescriptions are refilled	Reflects repeat usage and patient satisfaction

Cost and Pricing

• Average wholesale price (AWP): ~$55 per 10 mL bottle.[4]

• Typical treatment course: 1-2 drops in each eye once daily.

• Consumer price (out-of-pocket): ~$60-65 per bottle.

• Margins depend on manufacturing, marketing, and distribution costs.

Competitive Landscape

• OTC redness relievers (e.g., Visine, Lumify OTC): Higher sales volume but less targeted, with rebound redness issues.

• Prescription alternatives for ocular inflammation: Cyclosporine emulsion, lifitegrast, with significantly higher costs and different mechanisms.

Regulatory and Reimbursement Conditions

• FDA approved LUMIFY in 2018.

• It is covered under private insurance plans; some coverage is subject to prior authorization.

• No significant legal or patent disputes reported.[5]

Investment Risks and Opportunities

Risks

• Market Penetration: Consumer and physician acceptance may stagnate due to established OTC brands.

• Competition: OTC market dominance by brands like Visine, and new entrants with similar mechanisms.

• Pricing Pressure: Insurance reimbursement dynamics may limit profitability growth.

• Regulatory Changes: Future regulations affecting vasoconstrictors could impact sales.

Opportunities

• Market Expansion: Growth in ocular redness and inflammation markets.

• Product Line Extensions: Development of formulations with extended duration or additional indications.

• Global Expansion: Licensing or direct entry in emerging markets with rising eye health issues.

• Brand Recognition: Increase in physician education and marketing to enhance prescribing.

Investment Outlook

• LUMIFY exhibits a strong revenue base with consistent growth potential.

• The product’s market penetration is still evolving, and increased physician prescribing could significantly boost sales.

• Its competitive positioning against OTC products favors continued premium pricing and margins.

• Long-term value depends on successful expansion, pipeline development, and navigating competitive pressures.

Key Takeaways

• LUMIFY holds substantial market share in a growing eye redness treatment market, with 2022 revenues near $200 million.

• The product benefits from a targeted mechanism, differentiating it from OTC vasoconstrictors.

• Competition from OTC brands remains stiff, but physician prescribing and consumer awareness efforts are vital for growth.

• Risks include regulatory shifts and market saturation; opportunities involve expansion and pipeline development.

FAQs

1. What are the primary factors impacting LUMIFY's market growth?
Physician prescribing habits, consumer awareness, OTC competition, and reimbursement policies directly influence growth.

2. How does LUMIFY compare to OTC redness treatments?
LUMIFY offers a prescription option with minimal rebound redness, targeting users with persistent eye redness potentially unmet by OTC brands.

3. What are the main cost considerations for LUMIFY?
Manufacturing, marketing, distribution, and reimbursement negotiations affect margins and net profitability.

4. What regulatory challenges could affect LUMIFY in the future?
Potential changes in vasoconstrictor regulations or new safety concerns could limit market access or require reformulation.

5. Is LUMIFY positioned for international expansion?
Yes, but success depends on local regulatory approvals, competitive landscape, and market readiness.

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References

[1] Market data compiled from IQVIA reports (2022).
[2] Goodman et al. (2020). Epidemiology of eye redness. Ophthalmic Epidemiology.
[3] Bausch + Lomb annual report (2022).
[4] Wholesale pricing data sourced from GoodRx (2023).
[5] FDA approvals and legal reports (2022).