Last Updated: May 26, 2026

menthol; methyl salicylate - Profile


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What are the generic sources for menthol; methyl salicylate and what is the scope of patent protection?

Menthol; methyl salicylate is the generic ingredient in one branded drug marketed by Hisamitsu Pharm Co and is included in one NDA. There are two patents protecting this compound. Additional information is available in the individual branded drug profile pages.

Menthol; methyl salicylate has twenty patent family members in sixteen countries.

Summary for menthol; methyl salicylate
International Patents:20
US Patents:2
Tradenames:1
Applicants:1
NDAs:1
DrugPatentWatch® Estimated Loss of Exclusivity (LOE) Date for menthol; methyl salicylate
Generic Entry Date for menthol; methyl salicylate*:
Constraining patent/regulatory exclusivity:
Dosage:
PATCH;TOPICAL

*The generic entry opportunity date is the latter of the last compound-claiming patent and the last regulatory exclusivity protection. Many factors can influence early or later generic entry. This date is provided as a rough estimate of generic entry potential and should not be used as an independent source.

US Patents and Regulatory Information for menthol; methyl salicylate

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Exclusivity Expiration
Hisamitsu Pharm Co SALONPAS menthol; methyl salicylate PATCH;TOPICAL 022029-001 Feb 20, 2008 OTC Yes Yes ⤷  Start Trial ⤷  Start Trial Y ⤷  Start Trial
Hisamitsu Pharm Co SALONPAS menthol; methyl salicylate PATCH;TOPICAL 022029-001 Feb 20, 2008 OTC Yes Yes ⤷  Start Trial ⤷  Start Trial Y ⤷  Start Trial
Hisamitsu Pharm Co SALONPAS menthol; methyl salicylate PATCH;TOPICAL 022029-002 Nov 5, 2012 OTC Yes Yes ⤷  Start Trial ⤷  Start Trial Y ⤷  Start Trial
Hisamitsu Pharm Co SALONPAS menthol; methyl salicylate PATCH;TOPICAL 022029-002 Nov 5, 2012 OTC Yes Yes ⤷  Start Trial ⤷  Start Trial Y ⤷  Start Trial
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Exclusivity Expiration

Menthol and Methyl Salicylate: Investment Scenario, Market Dynamics, and Financial Trajectory

Last updated: February 3, 2026

Executive Summary

Menthol and methyl salicylate are widely utilized compounds in pharmaceutical, personal care, and sensory products. Their market is driven by diverse applications spanning analgesics, topical rubs, flavoring agents, and the broader wellness industry. This analysis examines the current market landscape, growth drivers, competitive dynamics, and financial trajectories to inform investment strategies. Anticipated CAGR (Compound Annual Growth Rate) for the combined sector is projected at 4.8% over the next five years, reflecting increasing demand in emerging markets and expanding product applicability.


Market Overview

Parameter Menthol Methyl Salicylate
Global Market Size (2022) USD 530 million USD 340 million
CAGR (2023-2028) 4.9% 4.7%
Key Applications Pharmacology, personal care, flavors Topical analgesics, flavoring agents
Major Manufacturing Regions China, India, Europe, North America China, India, Europe

Source: MarketWatch (2023), Grand View Research (2023)


Market Dynamics

What are the main growth drivers?

  • Rising demand for topical analgesics: Both compounds are core ingredients in OTC products such as rubs and patches. The analgesic market is projected to grow at a CAGR of 5.1%, accelerated by aging populations and chronic pain prevalence.
  • Personal care expansion: Menthol’s cooling and invigorating properties, coupled with methyl salicylate’s aromatic profile, drive demand in oral, grooming, and cosmetic products.
  • Flavor and fragrance industry growth: Savory and mint-flavored products in food and beverages foster demand, especially in Asian markets.
  • Wellness and aromatherapy trends: Increased consumer focus on natural and herbal remedies expands application scope.

What are the key challenges?

  • Regulatory hurdles: Stringent regulations on topical analgesics and flavoring agents vary across regions, impacting market entry and product development.
  • Supply chain variability: Price volatility of raw materials (peppermint oil, salicylic acid) affects profitability.
  • Environmental concerns: Landmark regulations targeting waste management and emissions necessitate sustainable manufacturing practices.

Supply Chain and Production Breakdown

Component Menthol Methyl Salicylate
Main Raw Materials Mentha oil, synthetic precursors Salicylic acid, methyl chloride
Key Producers Symrise, Givaudan, Dongguan Jianlong Eastman Chemical, Fluka (Sigma-Aldrich)
Manufacturing Process Steam distillation, synthesis Esterification of salicylic acid
Raw Material Price Trends Increasing with climatic variability Fluctuating based on chemical prices

Financial Trajectory and Investment Analysis

Revenue Projections

Year Menthol (USD Mn) Methyl Salicylate (USD Mn) Total Market (USD Mn)
2023 530 340 870
2024 557 358 915
2025 585 377 962
2026 615 396 1,011
2027 647 417 1,064
2028 680 438 1,118

Notes: Assumes CAGR of approximately 4.8%.

Profitability and Market Shares

Company Estimated Share Revenue (2023) Notable Strategies
Symrise 20% USD 174 mn R&D focus on sustainable sourcing
Givaudan 18% USD 156 mn Diversification into sensory wellness
Eastman Chemical 15% USD 130 mn Vertical integration in manufacturing
Other competitors 47% USD 410 mn Consolidation and regional expansion

Investment Opportunities

  • Raw material vertical integration: Controlling supply chains mitigates volatility.
  • Research and innovation: Developing synthetic derivatives with enhanced efficacy.
  • Sustainability initiatives: Eco-friendly extraction and synthesis attract regulatory support and premium pricing.

Competitive Landscape

Aspect Key Players Strengths Challenges
Menthol Producers Symrise, Givaudan, Dongguan Jianlong Large R&D, global reach Price sensitivity, raw material dependency
Methyl Salicylate Makers Eastman, Sigma-Aldrich, Merck High purity standards, broad product portfolio Regulatory hurdles, environmental concerns

Market Entry Barriers:
High due to patent protections on certain derivatives, significant R&D investment, and established supply chains.


Regulatory Environment and Policy Considerations

Region Regulations Impact on Market
North America FDA, EPA standards for OTC drugs, flavor additives Stringent, requiring compliance; opportunities for innovation
European Union EMA standards, REACH registration Emphasis on safety and environmental sustainability
Asia-Pacific Less stringent but tightening regulations Growth potential through compliance investments

Policy Trends:
Increasing environmental sustainability regulations favor manufacturers adopting green extraction and synthesis methods.


Comparative Analysis: Menthol versus Methyl Salicylate

Aspect Menthol Methyl Salicylate
Primary Uses Analgesics, flavorings, personal care Topical analgesics, flavor enhancers
Production Methods Natural extraction (peppermint oil), synthetic Esterification of salicylic acid, synthetic
Market Size (2022) USD 530 million USD 340 million
Key Growth Drivers Wellness, flavors, aromatic applications Pain relief, herbal products, flavors
Regulatory Status Generally recognized as safe (GRAS) in many regions Subject to stricter regulations in certain markets

FAQs

1. What are the primary applications of menthol and methyl salicylate?
Menthol is mainly used in analgesics, personal care, and flavoring industries. Methyl salicylate primarily functions as a topical analgesic and flavoring agent.

2. Which regions present the highest growth potential?
Asia-Pacific regions, especially China and India, due to expanding pharmaceutical and personal care sectors, offer the highest growth prospects.

3. What are the key challenges for investors?
Regulatory compliance, raw material price volatility, environmental regulation adherence, and technological barriers to entry.

4. How sustainable are current manufacturing practices?
Sustainability is improving with companies adopting green extraction, renewable feedstocks, and waste reduction measures, driven by regulatory and consumer pressures.

5. What are future technological innovations?
Development of synthetic analogs with enhanced efficacy, bio-based extraction methods, and sustainable manufacturing processes.


Key Takeaways

  • Market Outlook: The combined global market for menthol and methyl salicylate is projected to grow at approximately 4.8% CAGR through 2028, reaching over USD 1.1 billion.
  • Growth Drivers: Rising demand in OTC analgesics, personal care, flavors, and wellness products. The trend towards natural and sustainable ingredients amplifies potential.
  • Competitive Landscape: Dominated by large multinationals with integrated supply chains and a focus on innovation and sustainability.
  • Investment Strategy: Focus on vertical integration of raw materials, R&D for advanced derivatives, and environmental sustainability to capture market share and ensure compliance.
  • Risks: Price volatility, regulatory hurdles, and environmental concerns necessitate strategic planning and risk management.

References

  1. MarketWatch, “Menthol Market Size & Share, 2022-2028,” 2023.
  2. Grand View Research, “Global Menthol Market Report,” 2023.
  3. FDA and European Medicines Agency publications on OTC analgesic regulations, 2022-2023.
  4. Industry reports on raw material sourcing and sustainability initiatives, 2023.
  5. Company annual reports and investor presentations (Symrise, Givaudan, Eastman Chemical), 2023.

End of Report

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Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. We do not provide individual investment advice. This service is not registered with any financial regulatory agency. The information we publish is educational only and based on our opinions plus our models. By using DrugPatentWatch you acknowledge that we do not provide personalized recommendations or advice. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.