Last updated: June 2, 2026
Calcium chloride injection 10% in plastic container is a widely sourced IV product, typically supplied by multiple FDA-registered manufacturers through distributor networks. In the US, availability and substitution are driven by FDA “Orange Book” status (where applicable), CGMP manufacturing capacity, and container/packaging format (plastic container vs glass vial), which can restrict interchangeability during supply constraints.
This page compiles the supplier landscape by focusing on the commercial supply chain: (1) manufacturers of calcium chloride injection products in plastic containers and (2) the major distributors that carry those manufacturer products under label/warehouse channels.
What companies supply Calcium Chloride 10% injection in plastic containers?
A “10% calcium chloride” IV product is generally sold as calcium chloride injection USP in a ready-to-use concentration, packaged in plastic containers (often via premix-style bag formats or unit-dose plastic containers depending on the specific listing). Suppliers typically include both branded and generic manufacturers plus their distributor partners.
Common supplier model: manufacturer + wholesale distributor
In practice, the “supplier” you buy from is often a distributor sourcing from one or more FDA-registered manufacturers. During shortages or fast-changing batch allocation, distributors can shift source manufacturers while keeping the same pack format.
Manufacturer-to-distributor flow
- Manufacturer produces calcium chloride injection USP 10%.
- Product is labeled and packaged for specific market SKUs (plastic container type).
- Wholesale distributor assigns the listing under that SKU and manages regional inventory.
What to check to confirm plastic container status
Because calcium chloride injection can be sold in both glass and plastic, supplier selection should be filtered by:
- Label claims for “plastic container” or container material description.
- NDC match at the pack level (concentration and container must align).
- Product code and dosage form (injection).
- USP statement (USP calcium chloride injection).
Which FDA-listed manufacturers make Calcium Chloride 10% injection in plastic containers?
The US supplier set is determined by FDA registration (facility + product) and commercial labeling via NDCs. The manufacturer names tied to “Calcium Chloride Injection, USP 10%” plastic container SKUs are what matter for supply continuity.
Where supplier names are most reliably verified
- FDA NDC directory (manufacturer labeler and packager).
- FDA registration and product listing databases (firm + product type).
- Product label inserts and distributor catalogs (confirm container material).
Container format can change without changing concentration
Two suppliers can share the same “calcium chloride injection 10%” concentration but differ on container (glass vs plastic) and sometimes on total volume (eg, 10 mL, 20 mL, 100 mL, or other unit sizes). This is often the practical reason supply is not interchangeable during substitution or procurement.
How many suppliers exist for Calcium Chloride 10% injection in plastic containers?
The market generally supports multiple concurrent sources. The exact count varies by:
- NDC-level packaging configuration (plastic container size and configuration).
- Current sourcing status (some NDCs may be temporarily suspended).
- Distributor portfolio changes.
Supply concentration tends to be higher in contracted manufacturing networks and lower where cold chain or specialized packaging constraints apply. Calcium chloride injection typically has broad sourcing, but plastic container availability can still be a bottleneck when packaging lines face downtime.
What distributors sell Calcium Chloride 10% in plastic containers?
High-turn IV products are commonly stocked by national and regional wholesalers that distribute hospital, clinic, and pharmacy supply.
Typical distributor channels
- National drug wholesalers supplying hospitals: inventory allocation across health systems.
- Specialty distributors where packaging format matters for formulary compliance.
- Group purchasing organizations (GPOs) that negotiate contracted distributor SKUs.
Why distributor lists change even if the manufacturer set stays stable
- NDC substitutions at the distributor level.
- Lot-to-lot source shifts.
- Contracting of alternate manufacturer NDCs that meet the same clinical label requirements.
When do supply gaps occur for Calcium Chloride 10% in plastic containers?
Supply constraints are usually not driven by drug substance scarcity alone. They are commonly caused by:
- Packaging line downtime for plastic containers.
- Logistics delays tied to plastic container suppliers.
- Temporary batch holds and sterility release delays.
- Unit-size discontinuations at the NDC level.
For procurement planning, the key risk is NDC-level availability for the specific plastic container pack size.
What generic or branded version risks affect procurement?
For calcium chloride injection, “generic” and “unbranded” supply is typically the commercial default in hospital procurement. Procurement risk is less about patent exclusivity and more about:
- NDC-specific packaging compliance.
- Sterility assurance release timing.
- Distributor allocation during shortage windows.
How does plastic container packaging affect interchangeability vs glass?
Even when concentration is the same (10% calcium chloride), container differences affect:
- Handling and administration workflow for nursing protocols.
- Compatibility checks (connector type, administration set compatibility).
- Visual inspection expectations.
- Storage and spill-handling procedures.
Procurement and pharmacy substitution decisions are therefore usually enforced at the NDC and container-type level.
What is the patent and exclusivity status for Calcium Chloride 10% injection?
Calcium chloride injection is generally treated as an established, non-biologic small-molecule product with a mature commercial history. Patent and exclusivity issues are typically not the primary driver of supplier count at current market timing for the injection product category, while NDC-level manufacturing continuity is the dominant driver of availability.
What are the practical next steps for finding the right supplier?
Use a two-step verification pipeline:
- Start with the exact NDC for “calcium chloride injection 10%” with “plastic container” container material.
- Pull manufacturer labeler information from FDA NDC labeling and then match that manufacturer to distributor listings by SKU.
This approach avoids the common mismatch where a distributor lists “10% calcium chloride injection” but supplies a different container format than required.
Key Takeaways
- Calcium chloride injection 10% in plastic containers is sourced by multiple manufacturers, but procurement is constrained by NDC-level plastic container configuration.
- “Supplier” in practice is often a distributor channel sourcing from one or more FDA-registered manufacturers; source can shift without changing the distributor’s SKU description.
- Container format (plastic vs glass) and unit size are the main interchangeability constraints during shortages.
- The most reliable way to lock supplier continuity is NDC-level verification tied to plastic container labeling.
FAQs
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How do I confirm a calcium chloride injection 10% listing is in a plastic container?
Verify the exact NDC and label description stating plastic container, then confirm with the package insert or label.
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Can I substitute calcium chloride injection 10% in glass with plastic?
Substitution depends on your institution’s formulary rules and administration compatibility checks; NDC-level substitution is typically required.
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Why is calcium chloride injection sometimes unavailable even when the drug is widely manufactured?
Availability often tracks plastic container packaging line uptime, sterility release timing, and NDC-level lot allocation rather than the active ingredient.
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Which documents should a hospital request from a supplier for calcium chloride 10%?
Lot/COA, current label/package insert, and NDC/packaging configuration confirmation aligned to the required container type.
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What’s the fastest way to secure an alternative source during a shortage?
Switch between NDCs that keep concentration and plastic container format constant, then validate compatibility and storage/handling requirements for the administration protocol.
References
- FDA. Orange Book: Approved Drug Products with Therapeutic Equivalence Evaluations.
- FDA. NDC Directory (National Drug Code).
- FDA. Drug Registration and Listing System (DRLS).
