Last updated: May 28, 2026
Advil PM is a fixed-dose combination of ibuprofen (NSAID) and diphenhydramine (H1 antihistamine) in an OTC format. Supplier mapping for this product depends on the specific market (US vs. other countries), strength, pack size, and current label/NDC. Without the exact Advil PM NDC/label/strength and the target country, a complete and accurate supplier list cannot be produced.
Who supplies the active ingredients for Advil PM (ibuprofen and diphenhydramine)?
Advil PM’s ingredient supply chain has two layers: API manufacturing and finished-dose OTC packaging.
Ibuprofen API: typical supplier categories
Ibuprofen APIs are generally sourced from:
- Large API manufacturers producing ibuprofen via proprietary or contracted chemical routes.
- Global specialty chemical firms supplying ibuprofen intermediates.
- Contract API producers for OTC and branded product supply.
Diphenhydramine API: typical supplier categories
Diphenhydramine APIs are generally sourced from:
- Established antihistamine API producers.
- Specialist API manufacturers supplying diphenhydramine salts (or direct API forms used by finished-dose formulators).
Which companies manufacture Advil PM finished tablets for retail sale?
Finished-dose “suppliers” for Advil PM can include:
- The branded product’s primary manufacturer (brand owner’s manufacturing network).
- Contract manufacturers producing OTC combination tablets under branded label.
How finished-dose OTC manufacturing is typically structured
For OTC combination products, the supplier is often responsible for:
- Blending and tablet compression
- Film coating (if applicable)
- Overcoating/handling of moisture-sensitive components
- Packaging line operations (bottles/blister packs)
What packaging and fulfillment suppliers support Advil PM (bottles, cartons, labels)?
OTC branded supply chains usually use separate vendors for:
- Bottle and closure components (plastic bottles, seals, caps)
- Cartons and printed retail packs
- Tamper-evident seals and security labels
- Lot coding, serialization where required, and distribution packaging
What does the Advil PM “supplier” question mean for procurement?
In procurement, “supplier” can refer to different roles:
- API vendor for ibuprofen
- API vendor for diphenhydramine
- finished-dose contract manufacturer (tableting and coating)
- packaging vendor for bottles, cartons, and labeling
- distributor/wholesaler supplying retail shelves and group purchasing organizations
Without the exact NDC/label being targeted, the supplier set can change by packaging configuration and manufacturing site.
Key Takeaways
- Advil PM contains ibuprofen + diphenhydramine, so suppliers split into API supply and finished-dose/tableting and packaging supply.
- A precise supplier list requires the specific Advil PM presentation (strength/pack) and market labeling, since suppliers vary by NDC and manufacturing site.
- In procurement and litigation-style supplier mapping, “suppliers” must be defined as API, finished-dose manufacturer, or packaging/labeling vendor.
FAQs
- Which NDCs correspond to Advil PM tablets in the US?
- Do ibuprofen and diphenhydramine APIs for OTC combinations come from the same vendor or different suppliers?
- Are Advil PM tablets produced by the brand owner’s plants or by contract manufacturers?
- How do bottle and carton suppliers get qualified for branded OTC packaging?
- What evidence on the Advil PM label typically identifies the manufacturer and manufacturing site?
References
- FDA. Drug Establishment Registration and Listing (DERP) information and product labeling resources. (Accessed 2026-05-28).
- FDA. Orange Book and CDER drug labeling resources. (Accessed 2026-05-28).
