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Suppliers and packagers for generic pharmaceutical drug: ACETYLCHOLINE CHLORIDE
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ACETYLCHOLINE CHLORIDE
Listed suppliers include manufacturers, repackagers, relabelers, and private labeling entitities.
| Applicant | Tradename | Generic Name | Dosage | NDA | NDA/ANDA | Supplier | Package Code | Package | Marketing Start |
|---|---|---|---|---|---|---|---|---|---|
| Bausch And Lomb | MIOCHOL-E | acetylcholine chloride | FOR SOLUTION;OPHTHALMIC | 020213 | NDA | Bausch & Lomb Incorporated | 24208-539-20 | 1 KIT in 1 BLISTER PACK (24208-539-20) * 2 mL in 1 VIAL * 2 mL in 1 AMPULE | 1993-09-22 |
| >Applicant | >Tradename | >Generic Name | >Dosage | >NDA | >NDA/ANDA | >Supplier | >Package Code | >Package | >Marketing Start |
Who Supplies Acetylcholine Chloride for Pharmaceutical Use?
Acetylcholine chloride is a regulated, low–molecular-weight active chemical used in neuroscience research and, in some jurisdictions, as a starting material for pharmaceutical and laboratory formulations. Supply chains typically route through fine-chemical and biochemical manufacturers that sell either acetylcholine chloride itself or closely related quaternary ammonium salts used in bioassay workflows.
What supplier types provide acetylcholine chloride?
Acetylcholine chloride is commonly sold by four supplier categories:
- Specialty fine-chemical manufacturers (produce and sell the API-grade chemical; often provide CoA, impurity profiles, and stability data).
- Research-grade biochemical vendors (frequent catalog availability; typically focus on life-science use).
- Custom synthesis and toll manufacturers (supply smaller lots under NDA or buyer specifications).
- Global distributors (source from multiple manufacturers and handle compliance documentation, shipping, and batch consolidation).
Which suppliers are commonly listed for acetylcholine chloride?
Below are established, frequently used procurement sources for acetylcholine chloride in pharma-adjacent purchasing channels (catalog and/or distribution). Supplier availability and exact grade (lab vs GMP) change by market.
| Supplier / Distributor | Typical listing role | Common procurement pattern |
|---|---|---|
| Merck (MilliporeSigma) | Catalog chemical supplier | Direct purchase with batch documentation for research and manufacturing support |
| TCI Chemicals | Catalog chemical supplier | Direct order, typically with documentation for lab and pilot use |
| Thermo Fisher Scientific (Invitrogen / Fisher Chemical brands) | Catalog chemical supplier and distributor | Direct purchase through life-science channels |
| Cayman Chemical | Biochemical supplier | Research-grade listings, CoA per lot |
| Abcam | Life-science reagent supplier | Catalog reagent availability for neuroscience assays |
| Alfa Aesar (Thermo Fisher brand) | Chemical supplier | Fine-chemical catalog supply |
| MedChemExpress | Research chemical vendor | Catalog supply for life-science use |
| Santa Cruz Biotechnology | Life-science reagent vendor | Catalog supply with CoA and lot traceability |
What documentation suppliers typically provide?
For regulated procurement, the practical requirement is consistency in lot documentation and specification control. The following items are the standard request set suppliers can provide depending on grade:
- Certificate of Analysis (CoA) per lot
- Specification sheet (purity, assay method)
- Impurity statement or chromatographic profile (where available)
- Residual solvents statement (if applicable to manufacturing route)
- Stability information and handling conditions
- Regulatory support pack for distribution (varies by supplier and grade)
How to differentiate “lab grade” versus “pharma-relevant” supply
Acetylcholine chloride listings often span research and industrial chemical grades. Buyers usually screen for:
- Intended use labeling: “for research use only” versus commercial/manufacturing use
- GMP availability: Whether the supplier offers GMP manufacture and GMP CoA
- Traceability: batch manufacturing records link, lot numbering consistency
- Toxicity and transport classification: SDS, UN shipping classification, and packaging constraints
- Impurity controls: presence of secondary salts, hydrolysis products, or quaternary ammonium impurities
Procurement risk points for acetylcholine chloride
Key operational constraints that affect supplier selection:
- Stability and storage: moisture and temperature handling matter for quaternary ammonium salts; packaging and storage conditions can drive shelf-life.
- Lot-to-lot variability: higher-purity grades reduce assay drift in bioassays and formulation work.
- Regulatory posture: some suppliers restrict certain intended uses or shipment lanes depending on jurisdiction.
- Supply continuity: research-grade catalog items can be intermittently available; pharma-grade supply depends on batch planning.
How procurement typically works in practice
Most pharmaceutical supply workflows for acetylcholine chloride follow one of two paths:
- Direct purchase from a primary catalog manufacturer (Merck, TCI, Thermo brands, etc.) for quick lead times and strong documentation.
- Distributor procurement (where multiple catalog sources exist) to consolidate orders and standardize compliance packs.
Key Takeaways
- Acetylcholine chloride is supplied mainly through catalog fine-chemical and biochemical vendors plus distributors; GMP-grade availability depends on the supplier and lot.
- The most used procurement sources are Merck (MilliporeSigma), TCI, Thermo Fisher (including Fisher/Invitrogen and Alfa Aesar brands), Cayman Chemical, Abcam, and other life-science reagent suppliers.
- Supplier differentiation should be based on grade labeling, CoA type (GMP vs research), impurity controls, and stability/handling documentation, not just catalog availability.
FAQs
1) Is acetylcholine chloride sold as an API by major chemical suppliers?
It is sold widely as a chemical reagent; whether it is supplied under API-like GMP depends on the specific supplier and grade offered for that lot.
2) Which suppliers have the most consistent CoA documentation for acetylcholine chloride?
Large catalog suppliers (notably Merck, TCI, and Thermo Fisher brands) typically provide consistent per-lot documentation packages.
3) Can distributors source acetylcholine chloride from multiple manufacturers?
Yes. Many distributors consolidate stock from multiple upstream sources, which affects impurity profile continuity unless a specific grade/manufacturer is specified.
4) What matters most for formulation or assay reproducibility?
Purity/assay method, impurity profile, and stability/handling requirements from the CoA and SDS per lot.
5) Are research-grade and pharma-relevant acetylcholine chloride the same?
No. Research-grade listings often carry “RUO” positioning and may lack GMP-manufacturing documentation or tighter impurity specifications.
References
[1] Merck. “Acetylcholine chloride.” Merck/Sigma-Aldrich product catalog. https://www.sigmaaldrich.com/
[2] TCI Chemicals. “Acetylcholine chloride.” TCI product catalog. https://www.tcichemicals.com/
[3] Thermo Fisher Scientific. “Acetylcholine chloride.” Fisher Scientific and Invitrogen product catalogs. https://www.thermofisher.com/
[4] Cayman Chemical. “Acetylcholine chloride.” Cayman Chemical product page. https://www.caymanchem.com/
[5] Abcam. “Acetylcholine chloride.” Abcam product catalog. https://www.abcam.com/
[6] Alfa Aesar. “Acetylcholine chloride.” Thermo Fisher Alfa Aesar catalog listings. https://www.alfa.com/
[7] MedChemExpress. “Acetylcholine chloride.” MedChemExpress product listing. https://www.medchemexpress.com/
[8] Santa Cruz Biotechnology. “Acetylcholine chloride.” Santa Cruz product page. https://www.scbt.com/
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