Suppliers and packagers for generic pharmaceutical drug: ACETYLCHOLINE CHLORIDE

ACETYLCHOLINE CHLORIDE

Listed suppliers include manufacturers, repackagers, relabelers, and private labeling entitities.

Applicant	Tradename	Generic Name	Dosage	NDA	NDA/ANDA	Supplier	Package Code	Package	Marketing Start
Bausch And Lomb	MIOCHOL-E	acetylcholine chloride	FOR SOLUTION;OPHTHALMIC	020213	NDA	Bausch & Lomb Incorporated	24208-539-20	1 KIT in 1 BLISTER PACK (24208-539-20) * 2 mL in 1 VIAL * 2 mL in 1 AMPULE	1993-09-22

Suppliers for the Pharmaceutical Drug: Acetylcholine Chloride

Last updated: July 28, 2025

Introduction

Acetylcholine chloride is a synthetic form of the neurotransmitter acetylcholine, widely utilized in both clinical and research settings. Its applications span from neurological studies to diagnostic procedures, making its supply chain critically important for pharmaceutical companies, research institutions, and diagnostic laboratories. The global landscape for sourcing acetylcholine chloride is shaped by a diverse array of manufacturers, raw material suppliers, and distributors. This article offers an in-depth review of the primary suppliers, highlighting key regional players, manufacturing capabilities, quality standards, and market trends.

Overview of Acetylcholine Chloride

Acetylcholine chloride functions as a cholinergic neurotransmitter, influencing muscle activation, memory, and autonomic nervous system regulation. Its pharmaceutical use includes as an experimental agent, in diagnostic tests for neuromuscular function, and occasionally in therapeutic formulations. Due to its high reactivity and short half-life in biological systems, the purity and stability of sourced acetylcholine chloride are paramount.

Major Suppliers and Manufacturers

Global Industry Players

1. Sigma-Aldrich / Merck KGaA

One of the largest global providers of biochemicals and pharmaceutical raw materials, Sigma-Aldrich supplies research-grade acetylcholine chloride. Their product portfolio emphasizes high purity standards (typically >98%), with strict adherence to Good Manufacturing Practices (GMP). The company services academic institutions, pharmaceutical companies, and diagnostic labs worldwide.

2. Tocris Bioscience (Bio-Techne)

Tocris is renowned for offering high-quality neurochemical reagents, including acetylcholine chloride. Their formulations emphasize stability and reproducibility, essential for electrophysiological and neuropharmacological applications. The company maintains rigorous quality controls and provides detailed technical datasheets.

3. Alfa Aesar (Thermo Fisher Scientific)

Alfa Aesar supplies acetylcholine chloride compatible with research and pharmaceutical-grade applications. Their materials comply with USP standards in certain formulations, making them suitable for various laboratory and development needs. Their distribution network spans North America, Europe, and Asia.

4. Avantor / VWR International

Avantor offers acetylcholine chloride in multiple grades, focusing on chemical purity and consistency. They serve pharmaceutical R&D, diagnostics, and clinical laboratories, with an emphasis on regulatory compliance.

Regional and Local Suppliers

1. Beijing Solarbio Science & Technology Co., Ltd. (China)

Chinese manufacturers like Solarbio provide acetylcholine chloride at competitive prices, primarily targeting Asian markets. These suppliers often produce in bulk, with variable standards of purity, emphasizing cost-effectiveness and scale.

2. Tokyo Chemical Industry (TCI) (Japan)

Tightly regulated, Japanese suppliers like TCI offer pharmaceutical and research-grade acetylcholine chloride. Their products meet strict quality specifications, catering to the high standards of the Asian and global markets.

3. Sigma-Aldrich China / Merck China

A localized branch of Sigma-Aldrich supplies acetylcholine chloride tailored for regional demand, maintaining international quality standards.

Supply Chain Considerations

Quality Standards

The critical factor when sourcing acetylcholine chloride involves compliance with pharmaceutical standards such as USP, EP, or JP. These standards specify purity, residual solvents, sterility, and stability requirements. Suppliers often provide Certificates of Analysis (CoA) and stability data to validate quality.

Regulatory Compliance

In regulated markets like the US and Europe, suppliers must adhere to GMP regulations. Suppliers with FDA approval or EMA certification are favored for pharmaceutical manufacturing.

Pricing and Lead Times

Availability often correlates with supplier’s geographic location, production capacity, and demand. Price points vary significantly; research-grade materials may range from $50 to $200 per gram, depending on purity and quantity. Lead times depend on procurement quantities and production schedules.

Supply Risks

Limited sourcing options from specialized manufacturers, geopolitical factors, and supply chain disruptions (e.g., due to COVID-19) pose risks. Long-term procurement strategies incorporate multiple suppliers and regional diversification.

Emerging Trends

Customization and Regulatory Trends

Manufacturers emphasizing tailored formulations, such as encapsulated or stabilized versions, meet specific research needs. Increasing regulatory scrutiny drives suppliers to expand GMP-certified product lines.

Sustainability and Green Chemistry

Growing emphasis on environmentally friendly manufacturing processes influences supplier selection, particularly for large-volume industrial procurement.

Digital and Supply Chain Transparency

Blockchain-based traceability and digital certification are gaining adoption, enhancing transparency and traceability in the supply chain.

Market Outlook

The demand for acetylcholine chloride remains robust, driven by preclinical research and diagnostic applications. Technological advances in neuropharmacology and diagnostic imaging expand its utility, encouraging suppliers to scale production and improve product standards. The market is likely to witness consolidation, with major players investing in capacity expansion and quality enhancements.

Key Takeaways

• Major suppliers include Sigma-Aldrich (Merck), Tocris (Bio-Techne), Alfa Aesar (Thermo Fisher), and Avantor, providing high-purity, GMP-compliant acetylcholine chloride.
• Regional providers in China and Japan serve growing Asian markets, often at lower costs but with variable quality assurance.
• Quality standards, regulatory compliance, and supply chain reliability are paramount in procurement decisions.
• The evolving landscape favors suppliers investing in green manufacturing practices and digital supply chain transparency.
• Market growth propelled by neurological research and diagnostics prompts increased production capacity and product innovation.

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FAQs

1. What are the primary applications of acetylcholine chloride in the pharmaceutical industry?

It serves mainly in neurophysiological research, diagnostic testing for neuromuscular disorders, and as a reagent in pharmacological studies. Its use in therapeutics is limited due to rapid degradation in the body.

2. How do I evaluate the quality of acetylcholine chloride from different suppliers?

Assess product certificates (CoA), verify compliance with relevant pharmacopeias (USP, EP), review impurity profiles, and confirm batch consistency. Regulatory certifications and supplier reputation are also critical.

3. Are there risks associated with sourcing acetylcholine chloride from emerging markets?

Yes, potential risks include variable raw material quality, lack of GMP certification, inconsistent batch testing, and logistical issues. Due diligence and supplier audits are recommended.

4. What are the regulatory considerations when purchasing acetylcholine chloride?

Depending on application, compliance with FDA, EMA, or other regional regulations is essential. For pharmaceutical manufacturing, GMP-certified sources are required, with proper documentation for traceability and quality.

5. How is the market for acetylcholine chloride expected to evolve over the next five years?

Market growth driven by research and diagnostics, coupled with technological advancements, will likely prompt increased production, product diversification, and stricter quality standards, fostering a competitive landscape.

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References

1. [1] Sigma-Aldrich Product Information. (Accessed 2023).
2. [2] Tocris Bioscience Product Data Sheets. (Accessed 2023).
3. [3] Alfa Aesar Material Specifications. (Accessed 2023).
4. [4] Avantor / VWR Catalog. (Accessed 2023).
5. [5] Market Reports on Neuropharmacology and Diagnostic Reagents. (2022).