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|Title:||Slow release vehicles for minimizing skin irritancy of topical compositions|
|Abstract:||.[.Staple.]. .Iadd.Stable.Iaddend., aqueous gel vehicles are provided for the topical application to the skin of irritating active ingredients such as retinoids, particularly tretinoin, with slow release of the active ingredient and minimal irritancy to the skin. The vehicles include a gelling agent effective to form a gel and hold the active ingredient in the aqueous medium for slow release on the skin, and an effective amount of an antioxidant to retard decomposition of the active ingredient. The vehicles and formulations are preferably aqueous emulsions which contain a solubilizing agent for the generally non-water soluble active ingredients, as well as usually an emulsifying agent and/or surfactant. Chelating agents, emollients, preservatives and other adjuvants and additives may also be included in the vehicles and formulations.|
|Inventor(s):||Bazzano; Gail S. (Metairie, LA)|
|Assignee:||Alyzan, Inc. (Metairie, LA)|
Patent Claim Types:|
see list of patent claims
|PCT Filed||June 07, 1999||PCT Application Number:||PCT/US90/03219|
|PCT Publication Date:||December 13, 1990||PCT Publication Number:||WO90/14833|
|Country||Document Number||Estimated Expiration||Supplementary Protection Certificate||SPC Country||SPC Expiration|
|Canada||2063576||<disabled in preview>|
|Germany||69029804||<disabled in preview>|
|European Patent Office||0481007||<disabled in preview>|
| This preview shows a limited data set|
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