|Title:||Slow release vehicles for minimizing skin irritancy of topical compositions|
|Abstract:||.[.Staple.]. .Iadd.Stable.Iaddend., aqueous gel vehicles are provided for the topical application to the skin of irritating active ingredients such as retinoids, particularly tretinoin, with slow release of the active ingredient and minimal irritancy to the skin. The vehicles include a gelling agent effective to form a gel and hold the active ingredient in the aqueous medium for slow release on the skin, and an effective amount of an antioxidant to retard decomposition of the active ingredient. The vehicles and formulations are preferably aqueous emulsions which contain a solubilizing agent for the generally non-water soluble active ingredients, as well as usually an emulsifying agent and/or surfactant. Chelating agents, emollients, preservatives and other adjuvants and additives may also be included in the vehicles and formulations.|
|Inventor(s):||Bazzano; Gail S. (Metairie, LA)|
|Assignee:||Alyzan, Inc. (Metairie, LA)|
Patent Claim Types:|
see list of patent claims
|PCT Filed||June 07, 1999||PCT Application Number:||PCT/US90/03219|
|PCT Publication Date:||December 13, 1990||PCT Publication Number:||WO90/14833|
|Country||Document Number||Estimated Expiration||Supplementary Protection Certificate||SPC Country||SPC Expiration|
|European Patent Office||0481007||► Subscribe|
|World Intellectual Property Organization (WIPO)||9014833||► Subscribe|
| This preview shows a limited data set|
Subscribe for full access, or try a Trial
The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Due to the complexity of determining patent expirations even in a single country, compounded by the diversity of global patent laws, it is advisable to have patent counsel verify freedom to operate.
Export unavailable in trial.
Subscribe for complete access.