|Title:||Oral therapeutic system having systemic action|
|Abstract:||The invention relates to a therapeutic system for peroral administration and having systemic action, which system is in the form of a coated and/or laminated mono-compartment system for administering carbamazepine. The therapeutic system comprises (a) a wall made of a material which is permeable to water and impermeable to the components of the drug-containing core, (b) a core containing finely particulate carbamazepine as drug and, as auxiliaries, a protective colloid that inhibits the crystal growth of carbamazepine in the presence of water, a swellable hydrophilic polymer and, optionally, a water-soluble compound for inducing osmosis and/or further pharmaceutically acceptable excipients, and (c) a passageway through the wall (a) for delivering the core components to the environmental body fluid. The therapeutic system can be used as an anticonvulsive for the treatment of convulsive states, especially epileptic states.|
|Inventor(s):||Khanna; Satish C. (Bottmingen, CH), Ruttimann; Theresa (Basel, CH)|
|Assignee:||Ciba-Geigy Corporation (Ardsley, NY)|
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