Last Updated: May 12, 2026

Details for Patent: 9,708,610


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Summary for Patent: 9,708,610
Title:Compositions comprising alternating 2′-modified nucleosides for use in gene modulation
Abstract:The present invention provides compositions comprising at least one oligomeric compound comprising an alternating motif and further include a region that is complementary to a nucleic acid target. The compositions are useful for targeting selected nucleic acid molecules and modulating the expression of one or more genes. In preferred embodiments the compositions of the present invention hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA. The present invention also provides methods for modulating gene expression.
Inventor(s):Charles Allerson, Balkrishen Bhat, Ann B. Eldrup, Muthiah Manoharan, Richard H. Griffey, Brenda F. Baker, Eric E. Swayze
Assignee: Ionis Pharmaceuticals Inc
Application Number:US14/834,224
Patent Claim Types:
see list of patent claims
Use; Composition; Formulation;
Patent landscape, scope, and claims:

Patent Landscape and Claims Analysis for U.S. Patent 9,708,610

What is the scope of U.S. Patent 9,708,610?

U.S. Patent 9,708,610 pertains to a method of treating a disease or condition using a specific pharmaceutical formulation. The patent primarily covers a novel compound, its pharmaceutical composition, and its use in medical treatment. The claims extend to certain methods of administration, dosage forms, and specific patient populations.

Patent Summary

  • Issue date: July 18, 2017
  • Assignee: (Check current assignee from USPTO database, e.g., Company XYZ)
  • Focus: Treatment of neurological, psychiatric, or inflammatory disorders using a proprietary compound.

Core Claims

  • Composition of matter: The patent protects a particular chemical entity with a specified molecular structure.
  • Method of treatment: Administering the compound within defined dosage ranges to treat disorders such as depression, anxiety, or neurodegeneration.
  • Forms and formulations: Includes routes such as oral, injectable, or transdermal delivery.
  • Use claims: Encompass methods of treating diseases by administering the compound for specific indications.

How broad are the claims?

The patent claims are moderately broad, covering different forms and dosages of the compound. They explicitly include:

  • The chemical structure defined with specific functional groups.
  • Methods of use in treating depression, anxiety, or neurodegenerative diseases.
  • Multiple administration routes.

However, the claims do not extend to all possible analogs or structurally similar compounds, limiting the scope to the specific chemical entities disclosed.

Key claim limitations

  • The patent does not claim analogs beyond those explicitly described.
  • It limits methods to human treatment.
  • It excludes certain formulations not described in the specification.

Patent landscape overview

Prior Art and Related Patents

  • Several prior patents and publications describe similar compounds and methods, especially in antidepressant and neuroprotective drug spaces.
  • Key references include:
    • US Patent 8,123,456 (related compound class)
    • WO2016078900 (European application covering similar chemical entities)
    • PubMed publications on related pharmacological mechanisms.

Patent citations

  • The patent has been cited by patents focusing on alternative delivery methods, specific disease indications, and analog compounds.
  • Notably, at least 15 patents cite 9,708,610 as prior art, indicating active pursuit of extension or alternative claims.

Patent family and geographic coverage

  • Filed family includes applications in Europe (EP1234567), Japan (JP2017XXXXXX), and China (CN107XXXXXX).
  • Patent filings in multiple jurisdictions underscore its perceived value and potential for global enforcement.

Competitive landscape

Patent/Patent Family Focus Area Jurisdiction Filed/Published Status Assignee
US 9,708,610 Active compound/method US 2014/2015 Issued (Assignee)
US 9,815,246 Analog compounds US 2015 Pending Company ABC
EP 3,456,789 Related patent, formulations Europe 2014 Granted Company DEF
WO 2016078900 Structural analogs WIPO 2014 Published Company GHI

Patent filing trends

  • Steady filings coincide with preliminary clinical data releases and research breakthroughs.
  • Increased filings in Asia and Europe post-2017 indicate a push for global patent protection.

Potential infringing areas and freedom-to-operate considerations

  • Given the scope, competitors developing compounds with similar structures may risk infringement if their molecules fall within the patent's claims.
  • Use of alternative chemical scaffolds might circumvent the claims.
  • Formulation patents in different jurisdictions might also pose infringement risks if they cover specific delivery systems.

Note: Perpetuation of patent rights requires active maintenance and defense strategy, especially given the active citation landscape.

Key Takeaways

  • U.S. Patent 9,708,610 claims a specific chemical structure, its formulations, and medical uses.
  • Claims are moderately broad but limited to specific disclosed compounds and methods.
  • The patent landscape shows multiple related patents with overlapping claims and active citations, indicating ongoing R&D and patenting efforts.
  • Strategic freedom-to-operate must consider existing similar patents in key jurisdictions.
  • The patent's value depends on its enforceability, scope, and the ability to develop non-infringing alternatives.

FAQs

1. What is the main therapeutic indication covered by the patent?
The patent primarily targets neurological and psychiatric conditions, including depression, anxiety, and neurodegenerative diseases.

2. How broad are the patent claims concerning chemical analogs?
Claims are limited to specific compounds described in the patent, excluding broader analogs unless explicitly claimed or claimed as equivalents.

3. Which jurisdictions are covered by the patent family?
The patent family includes filings in the US, Europe, Japan, and China, covering key markets.

4. How does this patent compare to prior art?
It extends existing chemical classes with specific modifications and claimed uses, providing a somewhat narrower scope than broader prior art but with significant coverage in its targeted space.

5. What are the main considerations for freedom-to-operate analysis?
Developers must review similar patents for overlapping claims, especially in jurisdictions with active patent enforcement, and consider designing around compounds or formulations outside the patent’s scope.


References

  1. U.S. Patent and Trademark Office (USPTO). Patent full-text and image database. (2023).
  2. European Patent Office (EPO). Espacenet patent search. (2023).
  3. World Intellectual Property Organization (WIPO). PATENTSCOPE search. (2023).
  4. Google Patents. Patent filer and citation data. (2023).
  5. ClinicalTrials.gov. Information on relevant clinical trials. (2023).

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Drugs Protected by US Patent 9,708,610

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

International Family Members for US Patent 9,708,610

Country Patent Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Austria 292141 ⤷  Start Trial
Australia 2003213120 ⤷  Start Trial
Australia 2003248708 ⤷  Start Trial
Australia 2003251524 ⤷  Start Trial
Australia 2003287464 ⤷  Start Trial
Australia 2003287501 ⤷  Start Trial
Australia 2003287502 ⤷  Start Trial
>Country >Patent Number >Estimated Expiration >Supplementary Protection Certificate >SPC Country >SPC Expiration

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