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Last Updated: March 28, 2024

Details for Patent: 9,090,558


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Which drugs does patent 9,090,558 protect, and when does it expire?

Patent 9,090,558 protects VUMERITY and is included in one NDA.

This patent has fifty-two patent family members in twenty-six countries.

Summary for Patent: 9,090,558
Title:Prodrugs of fumarates and their use in treating various diseases
Abstract: The present invention provides compounds of formula (I), ##STR00001## wherein: R.sub.1 is unsubstituted C.sub.1-C.sub.6 alkyl; L.sub.a is substituted or unsubstituted C.sub.1-C.sub.6 alkyl linker, substituted or unsubstituted C.sub.3-C.sub.10 carbocycle, substituted or unsubstituted heterocycle comprising one or two 5- or 6-member rings and 1-4 heteroatoms selected from N, O and S, or substituted or unsubstituted heteroaryl comprising one or two 5- or 6-member rings and 1-4 heteroatoms selected from N, O and S; and R.sub.2 and R.sub.3 are each, independently, H, substituted or unsubstituted C.sub.1-C.sub.6 alkyl, or substituted or unsubstituted C.sub.6-C.sub.10 aryl; or alternatively, R.sub.2 and R.sub.3, together with the nitrogen atom to which they are attached, form a substituted or unsubstituted heteroaryl comprising one or two 5- or 6-member rings and 1-4 heteroatoms selected from N, O and S or a substituted or unsubstituted heterocycle comprising one or two 5- or 6-member rings and 1-4 heteroatoms selected from N, O and S. The invention also provides pharmaceutical compositions and methods for treating neurological diseases, such as multiple sclerosis.
Inventor(s): Zeidan; Tarek A. (Watertown, MA), Duncan; Scott (Bedford, MA), Hencken; Christopher P. (Boston, MA), Wynn; Thomas Andrew (Lexington, MA), Sanrame; Carlos N. (Lexington, MA)
Assignee: Alkermes Pharma Ireland Limited (Dublin, IE)
Application Number:14/180,687
Patent Litigation and PTAB cases: See patent lawsuits and PTAB cases for patent 9,090,558
Patent Claim Types:
see list of patent claims
Use;

Drugs Protected by US Patent 9,090,558

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
Biogen Inc VUMERITY diroximel fumarate CAPSULE, DELAYED RELEASE;ORAL 211855-001 Oct 29, 2019 RX Yes Yes ⤷  Try a Trial ⤷  Try a Trial METHOD OF TREATING MULTIPLE SCLEROSIS ⤷  Try a Trial
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

International Family Members for US Patent 9,090,558

Country Patent Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Australia 2014239641 ⤷  Try a Trial
Australia 2016222363 ⤷  Try a Trial
Australia 2018200497 ⤷  Try a Trial
Brazil 112015022854 ⤷  Try a Trial
Canada 2906580 ⤷  Try a Trial
>Country >Patent Number >Estimated Expiration >Supplementary Protection Certificate >SPC Country >SPC Expiration

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