Details for Patent: 8,926,947

Summary for Patent: 8,926,947

Title:	Polyol and polyether iron oxide complexes as pharmacological and/or MRI contrast agents
Abstract:	Iron oxide complexes, pharmacological compositions and unit dosage thereof, and methods for their administration, of the type employing an iron oxide complex with a polyol, are disclosed. The pharmacological compositions employ a polysaccharide iron oxide complex, wherein the polysaccharide is a modified polyol such as a carboxyalkylated reduced dextran. The complex is stable to terminal sterilization by autoclaving. The compositions are suitable for parenteral administration to a subject for the treatment of iron deficiencies or as MRI contrast agent. The complex is substantially immunosilent, provide minimal anaphylaxis and undergo minimal dissolution in vivo. The pharmacological compositions of the complex contain minimal free iron which can be quantified by a variety of methods.
Inventor(s):	Ernest V. Groman, Kenneth G. Paul, Timothy B. Frigo, Howard Bengele, Jerome M. Lewis
Assignee:	Amag Pharmaceuticals Inc
Application Number:	US14/301,757
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for patent 8,926,947
Patent Claim Types: see list of patent claims	Use; Formulation;

Drugs Protected by US Patent 8,926,947

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Patented / Exclusive Use	Submissiondate

International Family Members for US Patent 8,926,947

Country	Patent Number	Estimated Expiration	Supplementary Protection Certificate	SPC Country	SPC Expiration
European Patent Office	1169062		C300558	Netherlands
European Patent Office	1169062		CA 2012 00050	Denmark
European Patent Office	1169062		92114	Luxembourg
European Patent Office	1169062		C01169062/01	Switzerland
European Patent Office	1169062		1290043-7	Sweden
European Patent Office	1169062		300558	Netherlands
European Patent Office	1169062		2012C/052	Belgium