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Last Updated: December 3, 2022

Details for Patent: 8,529,882


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Summary for Patent: 8,529,882
Title:Peptidomimetic protease inhibitors
Abstract: The present invention relates to peptidomimetic compounds useful as protease inhibitors, particularly as serine protease inhibitors and more particularly as hepatitis C NS3 protease inhibitors; intermediates thereto; their preparation including novel stereoselective processes to intermediates. The invention is also directed to pharmaceutical compositions and to methods for using the compounds for inhibiting HCV protease or treating a patient suffering from an HCV infection or physiological condition related to the infection. Also provided are pharmaceutical combinations comprising, in addition to one or more HCV serine protease inhibitors, one or more interferons exhibiting anti-HCV activity and/or one or more compounds having anti HCV activity and a pharmaceutically acceptable carrier, and methods for treating or preventing a HCV infection in a patient using the compositions. The present invention is also directed to a kit or pharmaceutical pack for treating or preventing HCV infection in a patient.
Inventor(s): Babine; Robert Edward (Franklin, MA), Chen; Shu Hui (Carmel, IN), Collado; Ivan (Madrid, ES), Garcia-Paredes; Cristina (Madrid, ES), Glass; John Irvin (Indianapolis, IN), Jin; Ling (Carmel, IN), Lamar; Jason Eric (Indianapolis, IN), Parker, III; Raymond Samuel (Doylestown, PA), Snyder; Nancy June (Lizton, IN), Sun; Xicheng David (Superior, CO), Guo; Deqi (Carmel, IN), Yip; Yvonne Yee Mai (Indianapolis, IN), Wang; Q. May (Indianapolis, IN), Victor; Frantz (Indianapolis, IN), Tebbe; Mark Joseph (Hamburg, DE), Perni; Robert B. (Marlborough, MA), Farmer; Luc (Montreal, CA)
Assignee: Vertex Pharmaceuticals Incorporated (Cambridge, MA)
Application Number:13/541,436
Patent Claim Types:
see list of patent claims
Use; Composition;

Drugs Protected by US Patent 8,529,882

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

International Family Members for US Patent 8,529,882

Country Patent Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Argentina 030591 See Plans and Pricing
Austria 431358 See Plans and Pricing
Austria 483686 See Plans and Pricing
Australia 2001288318 See Plans and Pricing
Australia 8831801 See Plans and Pricing
Brazil 0113666 See Plans and Pricing
>Country >Patent Number >Estimated Expiration >Supplementary Protection Certificate >SPC Country >SPC Expiration

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