Last Updated: November 9, 2026

Details for Patent: 8,497,284

Name: Drug Patent Intelligence for US Patent 8497284
Creator: DrugPatentWatch
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Summary for Patent: 8,497,284

Title:	C-met modulators and method of use
Abstract:	The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate, and/or modulate kinase receptor, particularly c-Met, KDF, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.
Inventor(s):	Lynne Canne Bannen, Diva Sze-Ming Chan, Jeff Chen, Lisa Esther Dalrymple, Timothy Patrick Forsyth, Tai Phat Huynh, Vasu Jammalamadaka, Richard George Khoury, James William Leahy, Morrison B. Mac, Grace Mann, Larry W. Mann, John M. Nuss, Jason Jevious Parks, Craig Stacy Takeuchi, Yong Wang, Wei Xu
Assignee:	Exelixis Inc
Application Number:	US13/249,815
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for patent 8,497,284
Patent Claim Types: see list of patent claims	Use; Composition;

Drugs Protected by US Patent 8,497,284

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Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Patented / Exclusive Use	Submissiondate
>Applicant	>Tradename	>Generic Name	>Dosage	>NDA	>Approval Date	>TE	>Type	>RLD	>RS	>Patent No.	>Patent Expiration	>Product	>Substance	>Delist Req.	>Patented / Exclusive Use	>Submissiondate

International Family Members for US Patent 8,497,284

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Country	Patent Number	Estimated Expiration	Supplementary Protection Certificate	SPC Country	SPC Expiration
European Patent Office	2213661	⤷ Start Trial	C300678	Netherlands	⤷ Start Trial
European Patent Office	2213661	⤷ Start Trial	CA 2014 00039	Denmark	⤷ Start Trial
European Patent Office	2213661	⤷ Start Trial	PA2014033	Lithuania	⤷ Start Trial
European Patent Office	2213661	⤷ Start Trial	C20140029 00117	Estonia	⤷ Start Trial
>Country	>Patent Number	>Estimated Expiration	>Supplementary Protection Certificate	>SPC Country	>SPC Expiration

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