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Serving leading biopharmaceutical companies globally:

Daiichi Sankyo
McKesson
Cipla
Argus Health
Chinese Patent Office
Merck
McKinsey
Medtronic
Covington
Boehringer Ingelheim

Generated: February 19, 2018

DrugPatentWatch Database Preview

Details for Patent: 8,492,389

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Which drugs does patent 8,492,389 protect, and when does it expire?

Patent 8,492,389 protects ZYDELIG and is included in one NDA.

This patent has fifty-three patent family members in twenty-nine countries.
Summary for Patent: 8,492,389
Title:Inhibitors of human phosphatidylinositol 3-kinase delta
Abstract: Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (PI3K.delta.) activity, and methods of treating diseases, such as disorders of immunity and inflammation, in which PI3K.delta. plays a role in leukocyte function are disclosed. Preferably, the methods employ active agents that selectively inhibit PI3K.delta., while not significantly inhibiting activity of other PI3K isoforms. Compounds are provided that inhibit PI3K.delta. activity, including compounds that selectively inhibit PI3K.delta. activity. Methods of using PI3K.delta. inhibitory compounds to inhibit cancer cell growth or proliferation are also provided. Accordingly, the invention provides methods of using PI3K.delta. inhibitory compounds to inhibit PI3K.delta.-mediated processes in vitro and in vivo.
Inventor(s): Sadhu; Chanchal (Bothell, WA), Dick; Ken (Bothell, WA), Treiberg; Jennifer (Redmond, WA), Sowell; C. Gregory (Mukilteo, WA), Kesicki; Edward A. (Bothell, WA), Oliver; Amy (Bothell, WA)
Assignee: ICOS Corporation (Indianapolis, IN)
Application Number:12/575,367
Patent Claim Types:
see list of patent claims
Compound; Composition;

Drugs Protected by US Patent 8,492,389

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted
Gilead Sciences Inc ZYDELIG idelalisib TABLET;ORAL 205858-001 Jul 23, 2014 RX Yes No ➤ Sign Up ➤ Sign Up Y Y ➤ Sign Up
Gilead Sciences Inc ZYDELIG idelalisib TABLET;ORAL 205858-002 Jul 23, 2014 RX Yes Yes ➤ Sign Up ➤ Sign Up Y Y ➤ Sign Up
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted

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Non-Orange Book US Patents Family Members for Patent 8,492,389

For Orange Book-listed patents (shown in the main table above) generic applications must certify that the listed patents are expired, invalid, or will not be infringed by generic entry.

The non-Orange Book patents listed below do not require formal certifications, so they do not automatically impede generic entry. Instead, they represent potential opportunities for branded firms to block generic entry through patent infringment challenges.

Patent No. Title Estimated Patent Expiration
6,518,277 Inhibitors of human phosphatidylinositol 3-kinase delta ➤ Sign Up
6,949,535 Inhibitors of human phosphatidyl-inositol 3-kinase delta ➤ Sign Up
9,487,772 Inhibitors of human phosphatidylinositol 3-kinase delta ➤ Sign Up
8,138,195 Inhibitors of human phosphatidylinositol 3-kinase delta ➤ Sign Up
8,637,533 Inhibitors of human phosphatidylinositol 3-kinase delta ➤ Sign Up
8,653,077 Inhibitors of human phosphatidylinositol 3-kinase delta ➤ Sign Up
8,623,881 Inhibitors of human phosphatidylinositol 3-kinase delta ➤ Sign Up
6,667,300 Inhibitors of human phosphatidylinositol 3-kinase delta ➤ Sign Up
6,800,620 Inhibitors of human phosphatidylinositol 3-kinase delta ➤ Sign Up
Patent No. Title Estimated Patent Expiration

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International Patents Family Members for US Patent 8,492,389

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Ukraine 76103 ➤ Sign Up
Slovenia 2223922 ➤ Sign Up
Slovenia 1939203 ➤ Sign Up
Serbia 51458 ➤ Sign Up
Yugoslavia 80402 ➤ Sign Up
Portugal 1939203 ➤ Sign Up
Portugal 1278748 ➤ Sign Up
Poland 213200 ➤ Sign Up
Poland 358590 ➤ Sign Up
New Zealand 532206 ➤ Sign Up
Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration

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Serving hundreds of leading biopharmaceutical companies globally:

Harvard Business School
AstraZeneca
Fuji
Baxter
Boehringer Ingelheim
Cerilliant
Express Scripts
Argus Health
Cantor Fitzgerald

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