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Serving leading biopharmaceutical companies globally:

Fuji
Farmers Insurance
Johnson and Johnson
Teva
Cipla
US Department of Justice
QuintilesIMS
Accenture
Chubb
McKesson

Generated: February 24, 2018

DrugPatentWatch Database Preview

Details for Patent: 7,851,509

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Which drugs does patent 7,851,509 protect, and when does it expire?

Patent 7,851,509 protects ZOLINZA and is included in one NDA.

This patent has eighty-six patent family members in twenty-eight countries.
Summary for Patent: 7,851,509
Title:Polymorphs of suberoylanilide hydroxamic acid
Abstract:The present invention provides methods of selectively inducing terminal differentiation, cell growth arrest and/or apoptosis of neoplastic cells, and/or inhibiting histone deacetylase (HDAC) by administration of pharmaceutical compositions comprising potent HDAC inhibitors. The oral bioavailability of the active compounds in the pharmaceutical compositions of the present invention is surprisingly high. Moreover, the pharmaceutical compositions unexpectedly give rise to high, therapeutically effective blood levels of the active compounds over an extended period of time. The present invention further provides a safe, daily dosing regimen of these pharmaceutical compositions, which is easy to follow, and which results in a therapeutically effective amount of the HDAC inhibitors in vivo. The present invention also provides a novel Form I polymorph of SAHA, characterized by a unique X-ray diffraction pattern and Differential Scanning Calorimetry profile, as well a unique crystalline structure.
Inventor(s): Miller; Thomas A. (Brookline, MA), Richon; Victoria M. (Wellesley, MA)
Assignee: Merck HDAC Research, LLC (Boston, MA)
Application Number:12/077,396
Patent Claim Types:
see list of patent claims
Composition; Dosage form; Use; Formulation;

Drugs Protected by US Patent 7,851,509

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted
Merck ZOLINZA vorinostat CAPSULE;ORAL 021991-001 Oct 6, 2006 RX Yes Yes ➤ Try a Free Trial ➤ Try a Free Trial Y TREATMENT OF CUTANEOUS MANIFESTATIONS IN PATIENTS WTIH CUTANEOUS T-CELL LYMPHOMA (CTCL) ➤ Try a Free Trial
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted

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Non-Orange Book US Patents Family Members for Patent 7,851,509

For Orange Book-listed patents (shown in the main table above) generic applications must certify that the listed patents are expired, invalid, or will not be infringed by generic entry.

The non-Orange Book patents listed below do not require formal certifications, so they do not automatically impede generic entry. Instead, they represent potential opportunities for branded firms to block generic entry through patent infringment challenges.

Patent No. Title Estimated Patent Expiration
7,148,257 Methods of treating mesothelioma with suberoylanilide hydroxamic acid ➤ Try a Free Trial
7,456,219 Polymorphs of suberoylanilide hydroxamic acid ➤ Try a Free Trial
8,101,663 Polymorphs of suberoylanilide hydroxamic acid ➤ Try a Free Trial
7,652,069 Polymorphs of suberoylanilide hydroxamic acid ➤ Try a Free Trial
7,847,122 Polymorphs of suberoylanilide hydroxamic acid ➤ Try a Free Trial
8,067,472 Methods of treating Hodgkin's and non-Hodgkin's lymphoma ➤ Try a Free Trial
7,732,490 Methods of treating cancer ➤ Try a Free Trial
7,375,137 Methods of treating cancer with HDAC inhibitors ➤ Try a Free Trial
7,399,787 Methods of treating cancer with HDAC inhibitors ➤ Try a Free Trial
Patent No. Title Estimated Patent Expiration

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International Patents Family Members for US Patent 7,851,509

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Russian Federation 2394022 ➤ Try a Free Trial
Ukraine 83065 ➤ Try a Free Trial
Slovenia 1663194 ➤ Try a Free Trial
Russian Federation 2530648 ➤ Try a Free Trial
Russian Federation 2010108448 ➤ Try a Free Trial
Norway 329984 ➤ Try a Free Trial
Norway 20044112 ➤ Try a Free Trial
Norway 328575 ➤ Try a Free Trial
Norway 20061348 ➤ Try a Free Trial
Mexico PA04008577 ➤ Try a Free Trial
Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration

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Serving hundreds of leading biopharmaceutical companies globally:

Dow
Fish and Richardson
Healthtrust
Julphar
Chubb
Daiichi Sankyo
Mallinckrodt
McKesson
Teva

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

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