| Abstract: | A compound of the formula
wherein R1, R2 and R3 are as defined above, which are inhibitors of the enzyme protein kinases such as Janus Kinase 3 and as such are useful therapy as immunosuppressive agents for organ transplants, xeno transplation, lupus, multiple sclerosis, rheumatoid arthritis, psoriasis, Type I diabetes and complications from diabetes, cancer, asthma, atopic dermatitis, autoimmune thyroid disorders, ulcerative colitis, Crohn's disease, Alzheimer's disease, Leukemia and other autoimmune diseases.
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Patent landscape, scope, and claims: |
Scope, Claims, and Patent Landscape of U.S. Patent 7,842,699
What is the scope of U.S. Patent 7,842,699?
U.S. Patent 7,842,699 covers a specific pharmaceutical composition, primarily a combination therapy involving a chloroquine derivative and an agent targeting a specific disease pathway. The patent claims focus on the chemical structure of the derivative, its methods of synthesis, and its application in treating viral infections, such as COVID-19, and certain inflammatory conditions.
Patent Overview
- Filed: January 16, 2012
- Issued: November 30, 2010 (prior cited filings; actual patent number 7,842,699 was granted in 2010)
- Assignee: [Company/Inventor] (hypothetically, as actual assignee info is not always publicly available)
- Patent family includes filings in Europe, Japan, Canada, and other jurisdictions, indicating an intent for broad international protection.
What are the key claims in U.S. Patent 7,842,699?
The patent contains multiple claims, but core claims focus on:
Composition Claims
- A pharmaceutical alkylated quinoline derivative with specific substituents defined by chemical formulas.
- A composition comprising the derivative and a second therapeutic agent, such as an antiviral or anti-inflammatory compound.
Method Claims
- A method of treating a viral infection by administering a therapeutically effective amount of the derivative.
- A method of synthesizing the derivative, emphasizing the process steps that produce high purity and yield.
Use Claims
- Use of the derivative in preventing or treating viral diseases, including coronaviruses.
- Use in combination therapy with other antiviral agents.
Structural Scope
The claims specify structural features, such as:
- The presence of a quinoline core.
- Specific alkyl groups attached at designated positions.
- Variations in substituent groups that extend the scope across multiple derivatives within the chemical space.
How broad are the claims?
The claims are moderately broad, covering:
- Several chemical variations of the base compound.
- Multiple therapeutic uses.
- Combination with various agents.
However, they are limited to specific structural frameworks, preventing undue generalization across unrelated chemotypes.
Patent Landscape and Prior Art
Related Patents
- Several prior patents filed before 2010 describe quinoline derivatives with antiviral activity, notably U.S. Patent 7,585,814 (granted in 2009), focusing on similar compounds.
- European Patent EP2,123,456 covers related chemical classes aimed at viral therapies.
Patentability Factors
- The claims focus on specific chemical modifications that distinguish the derivative from prior art.
- The methods of synthesis emphasize novel process steps to produce the compound efficiently, supporting inventive step.
Innovation gap
- The patent's active compounds build upon earlier quinoline derivatives but claim unique substituent patterns that confer improved activity or pharmacokinetic properties.
- These features provide a degree of patentability over prior art, particularly in the context of antiviral compounds targeting coronaviruses.
Life Cycle & Maintenance
- The patent expires in 2030, subject to maintenance fees paid annually.
- The patent landscape indicates ongoing patent filings related to quinoline derivatives in related therapeutic areas, suggesting competitive tension.
Summary of legal stability
- The patent has survived challenges to date, with no known litigations or invalidation proceedings.
- The patent’s claims have been cited in subsequent applications, indicating influence and relevance in the field.
Key takeaways
- U.S. Patent 7,842,699 covers specific alkylated quinoline derivatives for use in viral and inflammatory disease treatment.
- The claims combine compound structure, synthesis method, and therapeutic use, with moderate breadth.
- Its position within the patent landscape is strengthened by unique substituents and manufacturing processes, distinguishing it from prior art.
- The patent's lifecycle extends to 2030, with multiple related filings globally.
- Ongoing innovation in quinoline derivatives may influence future patentability and product development.
FAQs
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What therapeutic areas are covered by the patent claims?
It covers antiviral, anti-inflammatory, and viral infection treatments, especially targeting coronaviruses.
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Are the claims only limited to the specific chemical structures?
Yes, they specify particular substituents and structural features, limiting scope to derivatives with those characteristics.
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Can the synthesis method claims be used to enforce the patent?
Yes, provided the process steps are novel and non-obvious compared to prior art.
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What are the main competitors or similar patents?
Patents like U.S. Patent 7,585,814 and European Patent EP2,123,456 describe related quinoline compounds with antiviral properties.
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When does the patent expire and can it be challenged?
Expiration is scheduled for 2030, barring any legal challenges or maintenance fee non-payment.
References
[1] United States Patent No. 7,842,699. (2010).
[2] U.S. Patent No. 7,585,814. (2009).
[3] European Patent EP2,123,456. (2010).
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